SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Palmqvist Richard) srt2:(2010-2014)"

Sökning: WFRF:(Palmqvist Richard) > (2010-2014)

  • Resultat 61-62 av 62
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
61.
  • Wikberg, Maria L., et al. (författare)
  • High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis.
  • 2013
  • Ingår i: Tumor Biology. - : Springer Netherlands. - 1010-4283 .- 1423-0380. ; 34:2, s. 1013-1020
  • Tidskriftsartikel (refereegranskat)abstract
    • -An active stroma is important for cancer cell invasion and metastasis. We investigated the expression of fibroblast activation protein (FAP) in relation to patient prognosis in colorectal cancer. Colorectal cancer specimens from 449 patients were immunohistochemically stained with a FAP antibody and evaluated in the tumor center and tumor front using a semiquantitative four-level scale. FAP was expressed by fibroblasts in 85-90 % of the tumors examined. High versus no/low expression in the tumor center was associated with poor prognosis (multivariate hazard ratio, HR = 1.72; 95 % CI 1.07-2.77, p = 0.025). FAP expression in the tumor front, though more frequent than in the tumor center, was not associated with prognosis. FAP expression in the tumor center was more common in specimens with positive microsatellite instability (MSI) screening status and in patients with high CpG island methylator phenotype (CIMP) status. However, inclusion of MSI screening status and CIMP status in the multivariate analysis strengthened the risk estimates for high FAP expression in the tumor center (HR = 1.89; 95 % CI 1.13-3.14; p = 0.014), emphasizing the role of FAP as an independent prognostic factor. Stromal FAP expression is common in colorectal cancer, and we conclude that high FAP expression in the tumor center, but not the tumor front, is an independent negative prognostic factor.
  •  
62.
  • Winbo, Annika, et al. (författare)
  • Iron-deficiency anaemia, gastric hyperplasia, and elevated gastrin levels due to potassium channel dysfunction in the Jervell and Lange-Nielsen Syndrome
  • 2013
  • Ingår i: Cardiology in the Young. - : Cambridge University Press. - 1047-9511 .- 1467-1107. ; 23:3, s. 325-334
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim We investigated extra-cardiac clinical symptoms and signs in the rare Jervell and Lange-Nielsen Syndrome, characterised by impaired KCNQ1 function, a gene essential for gastric acid secretion. METHODS: All Swedish Jervell and Lange-Nielsen cases with double KCNQ1 mutations (14 cases) were investigated by medical record review, an interview, and were offered laboratory testing for iron-deficiency anaemia and gastrointestinal markers. RESULTS: A history of iron-deficiency anaemia in 12 of 14 patients and subjective gastrointestinal symptoms in 13 of 14 patients was revealed. Previous endoscopy in five cases had revealed no case of coeliac or inflammatory bowel disease but three cases of mucosal hyperplasia/dysplasia. Current signs of anaemia or iron substitution were present in 9 of 12 tested cases. Elevated levels of gastrin in seven of nine cases, pepsinogen in six of seven cases, and faecal calprotectin in nine of nine cases were present. A significant correlation between elevated gastrin levels and concurrent iron-deficiency and/or anaemia was revealed (p-value 0.039). CONCLUSIONS: A high frequency of extra-cardiac clinical symptoms and previous medical investigations was found. We propose that the Jervell and Lange-Nielsen Syndrome phenotypically includes gastrointestinal symptoms/signs and secondary iron-deficiency anaemia owing to hypochlorhydria on the basis of KCNQ1 mutations. The resultant elevated gastrin level is a potential risk factor for later gastrointestinal cancer. Clinical monitoring with regard to developing anaemia and hypergastrinaemia should be considered in the Jervell and Lange-Nielsen Syndrome.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 61-62 av 62
Typ av publikation
tidskriftsartikel (56)
konferensbidrag (3)
forskningsöversikt (2)
doktorsavhandling (1)
Typ av innehåll
refereegranskat (59)
övrigt vetenskapligt/konstnärligt (3)
Författare/redaktör
Palmqvist, Richard (50)
Overvad, Kim (21)
Boutron-Ruault, Mari ... (20)
Trichopoulou, Antoni ... (20)
Tumino, Rosario (20)
Khaw, Kay-Tee (20)
visa fler...
Jenab, Mazda (19)
Riboli, Elio (18)
Vineis, Paolo (18)
Boeing, Heiner (17)
Palli, Domenico (17)
Panico, Salvatore (17)
Olsen, Anja (16)
Kaaks, Rudolf (16)
Pischon, Tobias (16)
Clavel-Chapelon, Fra ... (15)
Dorronsoro, Miren (15)
Hallmans, Göran (14)
Skeie, Guri (13)
Tjønneland, Anne (13)
Barricarte, Aurelio (13)
Fedirko, Veronika (13)
Trichopoulos, Dimitr ... (13)
Peeters, Petra H (12)
Sánchez, Maria-José (12)
Norat, Teresa (12)
Bueno-de-Mesquita, H ... (12)
Öberg, Åke (11)
Wareham, Nick (10)
van Guelpen, Bethany (10)
Edin, Sofia (10)
Romieu, Isabelle (9)
Rinaldi, Sabina (9)
Aleksandrova, Krasim ... (9)
Tjonneland, Anne (9)
Key, Timothy J (8)
Lagiou, Pagona (8)
Morois, Sophie (8)
Rodríguez, Laudina (8)
Wikberg, Maria L (8)
Lukanova, Annekatrin (7)
Gunter, Marc J. (7)
Pala, Valeria (7)
Ferrari, Pietro (7)
Siersema, Peter D (7)
Ljuslinder, Ingrid (7)
Romaguera, Dora (7)
Crowe, Francesca L (7)
Teucher, Birgit (7)
Henriksson, Maria L (7)
visa färre...
Lärosäte
Umeå universitet (52)
Lunds universitet (12)
Karolinska Institutet (10)
Uppsala universitet (6)
Chalmers tekniska högskola (6)
Göteborgs universitet (4)
visa fler...
Sveriges Lantbruksuniversitet (4)
Kungliga Tekniska Högskolan (3)
Linköpings universitet (2)
Stockholms universitet (1)
visa färre...
Språk
Engelska (60)
Svenska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (43)
Lantbruksvetenskap (10)
Naturvetenskap (7)
Teknik (4)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy