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Träfflista för sökning "WFRF:(Perola Markus) "

Search: WFRF:(Perola Markus)

  • Result 91-91 of 91
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91.
  • Willer, Cristen J., et al. (author)
  • Discovery and refinement of loci associated with lipid levels
  • 2013
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1274-1283
  • Journal article (peer-reviewed)abstract
    • Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
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  • Result 91-91 of 91
Type of publication
journal article (89)
other publication (1)
doctoral thesis (1)
Type of content
peer-reviewed (88)
other academic/artistic (3)
Author/Editor
Perola, Markus (86)
Salomaa, Veikko (58)
Metspalu, Andres (38)
van Duijn, Cornelia ... (36)
Gieger, Christian (36)
Esko, Tõnu (36)
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Lind, Lars (35)
McCarthy, Mark I (35)
Wareham, Nicholas J. (34)
Samani, Nilesh J. (34)
Ripatti, Samuli (33)
Loos, Ruth J F (33)
Uitterlinden, André ... (33)
Hayward, Caroline (33)
Rudan, Igor (32)
Deloukas, Panos (32)
Luan, Jian'an (32)
Boehnke, Michael (31)
Hofman, Albert (31)
Mangino, Massimo (29)
Kaprio, Jaakko (29)
Jula, Antti (28)
Laakso, Markku (28)
Stefansson, Kari (28)
Groop, Leif (27)
Campbell, Harry (27)
Langenberg, Claudia (27)
Ingelsson, Erik (27)
Thorleifsson, Gudmar (27)
Wilson, James F. (27)
Gudnason, Vilmundur (27)
Vollenweider, Peter (27)
Mohlke, Karen L (26)
Harris, Tamara B (26)
Chasman, Daniel I. (25)
Tuomilehto, Jaakko (25)
Ridker, Paul M. (24)
Thorsteinsdottir, Un ... (24)
Willemsen, Gonneke (24)
Boomsma, Dorret I. (24)
Munroe, Patricia B. (24)
Polasek, Ozren (24)
Kanoni, Stavroula (24)
Kuusisto, Johanna (23)
Spector, Tim D. (23)
Hicks, Andrew A. (23)
Pramstaller, Peter P ... (23)
Rivadeneira, Fernand ... (23)
Zhao, Jing Hua (23)
Boerwinkle, Eric (23)
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University
Uppsala University (63)
Lund University (56)
Karolinska Institutet (47)
Umeå University (27)
University of Gothenburg (17)
Högskolan Dalarna (6)
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Stockholm University (2)
Stockholm School of Economics (2)
Mid Sweden University (2)
University of Skövde (2)
Chalmers University of Technology (2)
Luleå University of Technology (1)
Linköping University (1)
Södertörn University (1)
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Language
English (90)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (74)
Natural sciences (11)
Social Sciences (1)

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