| 31. |
- Holmes, Emily A., et al.
(författare)
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Mental Imagery in Depression : Phenomenology, Potential Mechanisms, and Treatment Implications
- 2016
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Ingår i: ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 12. - : ANNUAL REVIEWS. - 1548-5951 .- 1548-5943. - 9780824339128 ; , s. 249-280
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Bokkapitel (refereegranskat)abstract
- Mental imagery is an experience like perception in the absence of a percept. It is a ubiquitous feature of human cognition, yet it has been relatively neglected in the etiology, maintenance, and treatment of depression. Imagery abnormalities in depression include an excess of intrusive negative mental imagery; impoverished positive imagery; bias for observer perspective imagery; and overgeneral memory, in which specific imagery is lacking. We consider the contribution of imagery dysfunctions to depressive psychopathology and implications for cognitive behavioral interventions. Treatment advances capitalizing on the representational format of imagery (as opposed to its content) are reviewed, including imagery rescripting, positive imagery generation, and memory specificity training. Consideration of mental imagery can contribute to clinical assessment and imagery-focused psychological therapeutic techniques and promote investigation of underlying mechanisms for treatment innovation. Research into mental imagery in depression is at an early stage. Work that bridges clinical psychology and neuroscience in the investigation of imagery-related mechanisms is recommended.
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| 32. |
- Isfort, I., et al.
(författare)
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Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone
- 2019
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Tumors of soft tissue and bone represent a heterogeneous group of neoplasias characterized by a wide variety of genetic aberrations. Albeit knowledge on tumorigenesis in mesenchymal tumors is continuously increasing, specific insights on altered signaling pathways as a basis for molecularly targeted therapeutic strategies are still sparse. The aim of this study was to determine the involvement ofYAP1/TAZ-mediated signals in tumors of soft tissue and bone. Expression levels of YAP1 and TAZ were analyzed by immunohistochemistry in a large cohort of 486 tumor specimens, comprising angiosarcomas (AS), Ewing sarcomas, leiomyosarcomas, malignant peripheral nerve sheath tumors (MPNST), solitary fibrous tumors, synovial sarcomas (SySa), well-differentiated/dedifferentiated/ pleomorphic and myxoid liposarcomas (MLS). Moderate to strong nuclear staining ofYAP1 and TAZ was detected in 53% and 33%, respectively. YAP1 nuclear expression was most prevalent in MPNST, SySa and MLS, whereas nuclear TAZ was predominately detected in AS, MLS and MPNST. In a set of sarcoma cell lines, immunoblotting confirmed nuclear localization ofYAP1 and TAZ, corresponding to their transcriptionally active pool. Suppression ofYAP1/TAZ-TEAD mediated transcriptional activity significantly impaired sarcoma cell viability in vitro and in vivo. Our findings identify nuclear YAP1 and TAZ positivity as a common feature in subsets of sarcomas of soft tissue and bone and provide evidence ofYAP1/TAZ-TEAD signaling as a specific liability to be considered as a new target for therapeutic intervention. Nuclear YAP1/TAZ expression may represent a biomarker suited to identify patients that could benefit fromYAP1/TAZ-TEAD directed therapeutic approaches within future clinical trials.
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| 33. |
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| 34. |
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| 35. |
- Konstantinov, A., et al.
(författare)
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Data management services of NorduGrid
- 2005
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Ingår i: CERN-2005-002. ; 2, s. 765-766
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Konferensbidrag (refereegranskat)abstract
- In common grid installations, services responsible for storing big data chunks, replication of those data and indexing their availability are usually completely decoupled. And a task of synchronizing data is passed to either user-level tools or separate services (like spiders) which are subject to failure and usually cannot perform properly if one of underlying services fails too. The NorduGrid Smart Storage Element (SSE) was designed to try to overcome those problems by combining the most desirable features into one service. It uses HTTPS/G for secure data transfer, Web Services for control (through same HTTPS/G channel) and can provide information to indexing services used in middlewares based on the Globus Toolkit (TM). At the moment, those are the Replica Catalog and the Replica Location Service. The modular internal design of the SSE and the power of C++ object programming allows to add support for other indexing services in an easy way. There are plans to complement it with a Smart Indexing Service capable of resolving inconsistencies hence creating a robust distributed data storage system.
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| 36. |
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| 37. |
- Langgard Nielsen, J., et al.
(författare)
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Experiences with Data Indexing services supported by the NorduGrid middleware
- 2005
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Ingår i: CERN-2005-002. ; 2, s. 673-675
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Konferensbidrag (refereegranskat)abstract
- The NorduGrid middleware, ARC, has integrated support for querying and registering to Data Indexing services such as the Globus Replica Catalog and Globus Replica Location Server. This support allows one to use these indexing services for for example brokering during jobsubmission, automatic registration of files and many other things. This integrated support is complemented by a set of command-line tools for registering to and querying these Data Indexing services. In this article we will describe experiences with these indexing services both from a daily work point of view and in production environments such as the Atlas Data- Challenges 1 and 2. We will describe the advantages of such Data Indexing services as well as their shortcomings. Finally we will present a proposal for an extended Smart Indexing Service which should deal with the shortcomings described. Such an indexing service is being designed at the moment.
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| 38. |
- Pajchel, K., et al.
(författare)
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Usage statistics and usage patterns on the NorduGrid: Analyzing the logging information collected on one of the largest production Grids of the world
- 2005
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Ingår i: CERN-2005-002. ; 2, s. 711-714
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Konferensbidrag (refereegranskat)abstract
- The Nordic Grid facility (NorduGrid [1]) came into operation during summer 2002 when the Scandinavian ATLAS HEP group started to use the Grid for the ATLAS Data Challenges (DC) and was thus the first Grid ever contributing to an ATLAS production. Since then, the Grid facility has been in continuous 24/7 operation. NorduGrid is being used by a growing set of active users from various scientific areas including physics, chemistry, biology and informatics. It has given major contributions to the ATLAS Data Challenge 1 [2] and the ongoing Data Challenge 2. · The increasing number of resources has made NorduGrid one of the largest production Grids in the world, continuously running on more than 30 sites more than 3000 CPUs. · The resources range from small test clusters at academic institutions to large farms at several supercomputer centers and the NorduGrid software runs on clusters with very different Linux distributions. This presentation gives a short overview of the design and implementation of the NorduGrid middleware, logging and monitoring facilities. It will be followed by a description of a typical job on NorduGrid and the information about its parameters which are monitored online and persistified in the logging service.
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| 39. |
- Patiño, Jairo, et al.
(författare)
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Unveiling the nature of a miniature world : a horizon scan of fundamental questions in bryology
- 2022
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Ingår i: Journal of Bryology. - : Informa UK Limited. - 0373-6687 .- 1743-2820. ; 44:1, s. 1-34
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Tidskriftsartikel (refereegranskat)abstract
- Introduction. Half a century since the creation of the International Association of Bryologists, we carried out a review to identify outstanding challenges and future perspectives in bryology. Specifically, we have identified 50 fundamental questions that are critical in advancing the discipline.Methods. We have adapted a deep-rooted methodology of horizon scanning to identify key research foci. An initial pool of 258 questions was prepared by a multidisciplinary and international working group of 32 bryologists. A series of online surveys completed by a broader community of researchers in bryology, followed by quality-control steps implemented by the working group, were used to create a list of top-priority questions. This final list was restricted to 50 questions with a broad conceptual scope and answerable through realistic research approaches.Key results. The top list of 50 fundamental questions was organised into four general topics: Bryophyte Biodiversity and Biogeography; Bryophyte Ecology, Physiology and Reproductive Biology; Bryophyte Conservation and Management; and Bryophyte Evolution and Systematics. These topics included 9, 19, 14 and 8 questions, respectively.Conclusions. Although many of the research challenges identified are not newly conceived, our horizon-scanning exercise has established a significant foundation for future bryological research. We suggest analytical and conceptual strategies and novel developments for potential use in advancing the research agenda for bryology.
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| 40. |
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