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  • Zhou, Sirui, et al. (author)
  • A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
  • 2021
  • In: Nature Medicine. - : Springer Nature. - 1078-8956 .- 1546-170X. ; 27:4, s. 659-667
  • Journal article (peer-reviewed)abstract
    • To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19 death or ventilation (odds ratio (OR) = 0.54, P = 7 × 10−8), hospitalization (OR = 0.61, P = 8 × 10−8) and susceptibility (OR = 0.78, P = 8 × 10−6). Measuring OAS1 levels in 504 individuals, we found that higher plasma OAS1 levels in a non-infectious state were associated with reduced COVID-19 susceptibility and severity. Further analyses suggested that a Neanderthal isoform of OAS1 in individuals of European ancestry affords this protection. Thus, evidence from MR and a case–control study support a protective role for OAS1 in COVID-19 adverse outcomes. Available pharmacological agents that increase OAS1 levels could be prioritized for drug development.
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  • Result 41-41 of 41
Type of publication
journal article (40)
other publication (1)
Type of content
peer-reviewed (39)
other academic/artistic (2)
Author/Editor
Richards, J. Brent (36)
Ohlsson, Claes, 1965 (18)
Rivadeneira, Fernand ... (14)
Kiel, Douglas P. (13)
Karasik, David (11)
Evans, David M (10)
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Hofman, Albert (10)
Nakanishi, Tomoko (10)
Vandenput, Liesbeth, ... (9)
Uitterlinden, André ... (9)
Forgetta, Vincenzo (9)
Karlsson, Magnus (8)
Lorentzon, Mattias, ... (8)
Eriksson, Joel (8)
Hsu, Yi-Hsiang (8)
Pettersson-Kymmer, U ... (8)
Butler-Laporte, Guil ... (8)
Frithiof, Robert (7)
Langenberg, Claudia (7)
Mellström, Dan, 1945 (7)
Grundberg, Elin (7)
Zillikens, M. Carola (7)
Harris, Tamara B (7)
Liu, Yongmei (7)
Psaty, Bruce M (7)
Timpson, Nicholas J. (7)
Hultström, Michael, ... (6)
Spector, Tim D. (6)
Spector, Timothy D (6)
Cupples, L. Adrienne (6)
Mitchell, Braxton D. (6)
Wilson, Scott G. (6)
Chen, Yiheng (6)
Brown, Matthew A. (6)
Nethander, Maria, 19 ... (5)
Cooper, Cyrus (5)
Soranzo, Nicole (5)
Eisman, John A (5)
McCarthy, Mark I (5)
Lipcsey, Miklós (5)
van Duijn, Cornelia ... (5)
Scott, Robert A (5)
Kähönen, Mika (5)
Lehtimäki, Terho (5)
Stefansson, Kari (5)
Reeve, Jonathan (5)
Smith, George Davey (5)
Lu, Tianyuan (5)
Hveem, Kristian (5)
Yoshiji, Satoshi (5)
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University
Uppsala University (23)
University of Gothenburg (19)
Umeå University (15)
Lund University (13)
Karolinska Institutet (11)
Stockholm University (1)
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Linköping University (1)
Mid Sweden University (1)
Swedish University of Agricultural Sciences (1)
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Language
English (41)
Research subject (UKÄ/SCB)
Medical and Health Sciences (39)
Natural sciences (5)

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