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Sökning: WFRF:(Rydén E)

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  • Rohm, Maria, et al. (författare)
  • An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
  • 2016
  • Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 22:10, s. 1120-1130
  • Tidskriftsartikel (refereegranskat)abstract
    • Cachexia represents a fatal energy-wasting syndrome in a large number of patients with cancer that mostly results in a pathological loss of skeletal muscle and adipose tissue. Here we show that tumor cell exposure and tumor growth in mice triggered a futile energy-wasting cycle in cultured white adipocytes and white adipose tissue (WAT), respectively. Although uncoupling protein 1 (Ucp1)-dependent thermogenesis was dispensable for tumor-induced body wasting, WAT from cachectic mice and tumor-cell-supernatant-treated adipocytes were consistently characterized by the simultaneous induction of both lipolytic and lipogenic pathways. Paradoxically, this was accompanied by an inactivated AMP-activated protein kinase (Ampk), which is normally activated in peripheral tissues during states of low cellular energy. Ampk inactivation correlated with its degradation and with upregulation of the Ampk-interacting protein Cidea. Therefore, we developed an Ampk-stabilizing peptide, ACIP, which was able to ameliorate WAT wasting in vitro and in vivo by shielding the Cidea-targeted interaction surface on Ampk. Thus, our data establish the Ucp1-independent remodeling of adipocyte lipid homeostasis as a key event in tumor-induced WAT wasting, and we propose the ACIP-dependent preservation of Ampk integrity in the WAT as a concept in future therapies for cachexia.
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  • Rydén, E., et al. (författare)
  • Autism spectrum disorder in an adult psychiatric population : A naturalistic cross sectional controlled study
  • 2008
  • Ingår i: Clinical Neuropsychiatry. - 1724-4935. ; 5:1, s. 13-21
  • Tidskriftsartikel (refereegranskat)abstract
    • Object: Autism spectrum disorders (ASD) e.g. autism, Asperger syndrome, and Pervasive developmental disorder not otherwise specified, have yet to become a focus of attention in clinical adult psychiatry. The aims of the present study were firstly to characterize psychiatric patients with ASD in regard to demographical factors, psychiatric comorbidity and personality traits and compare the ASD group with a psychiatric control group in these respects. Secondly. we wanted to compare differences of personalily traits between females and males in the ASD group.Method: Adult psychiatric patients where ASD or attention deficit hyperactivily disorder (ADHD) was suspected were referred to a tertiary unit in Stockholm 2001-2006. All patients diagnosed at the unit with ASD (n=84; 39 females and 45 males) were consecutively included and compared to all 46 identically interviewed and assessed patients who did not receive an ASD or ADHD diagnosis. Among scales used were the Global Assessment of Functioning (GAF), SCID II Screen, and Swedish universities Scales of Personality (SSP).Results: ASD patients had an equal educational level but a lower social and occupational functioniug. Their GAF scores were significantly lower compared to the control group. Prior to referral, major depressive disorder and obsessive-compulsive disorders were the most common psychiatric diagnoses. In the assessment approximately 1/3 fulfilled diagnostic criteria for comorbid ADHD. The patients with ASD also had significantly more schizotypal and avoidant personality traits according to SCID II screen. In SSP, patients with ASD rated themselves significantly higher on Stress-susceptibility, Embitterment, Detachment, Trait irritability and Lack of assertiveness than controls. Females with ASD scored significantly higher than males on borderline and passive-aggressive traits according to the SCID II Screen and on Embitterment and Trait irritability m the SSP.Conclusions: We could show that psychiatric patients with ASD have a low level of functioning and a personality profile which is gender specific. This may contribute to the identification and understanding of patients with ASD in adult psychiatry.
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