↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Shaw Leslie M.) "

Sökning: WFRF:(Shaw Leslie M.)

Resultat 51-53 av 53

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
51.	Vanderstichele, Hugo, et al. (författare) Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. 2012 Ingår i: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 8:1, s. 65-73 Tidskriftsartikel (refereegranskat)abstract Numerous studies show that the cerebrospinal fluid biomarkers total tau (T-tau), tau phosphorylated at threonine 181 (P-tau(181P)), and amyloid-β (1-42) (Aβ(1-42)) have high diagnostic accuracy for Alzheimer's disease. Variability in concentrations for Aβ(1-42), T-tau, and P-tau(181P) drives the need for standardization.
52.	Zetterberg, Henrik, 1973, et al. (författare) Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression. 2016 Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 73:1, s. 60-67 Tidskriftsartikel (refereegranskat)abstract The extent to which large-caliber axonal degeneration contributes to Alzheimer disease (AD) progression is unknown. Cerebrospinal fluid (CSF) neurofilament light (NFL) concentration is a general marker of damage to large-caliber myelinated axons.
53.	Öhrfelt, Annika, 1973, et al. (författare) Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive Individuals. 2023 Ingår i: Neurology. - 0028-3878 .- 1526-632X. ; 100:3 Tidskriftsartikel (refereegranskat)abstract To test the associations between the presynaptic growth-associated protein 43 (GAP-43) protein, quantified in cerebrospinal fluid (CSF), and biomarkers of Alzheimer's disease (AD) pathophysiology, cross-sectionally and longitudinally.In this retrospective study, GAP-43 was measured in participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort using an in-house ELISA method, and levels were compared between groups, both cross-sectionally and longitudinally. Linear regression models tested the associations between biomarkers of AD (Aβ and tau pathologies, neurodegeneration and cognition) adjusted by age, sex and diagnosis. Linear mixed effect models (LME) evaluated how baseline GAP-43 predicts brain hypometabolism, atrophy and cognitive decline over time. Cox-proportional hazard regression models tested how GAP-43 levels and Aβ status, at baseline, increased the risk of progression to AD dementia over time.This study included 786 participants from the ADNI cohort, which were further classified in cognitively unimpaired (CU) Aβ-negative (nCU-=197); CU Aβ-positive (nCU+=55), mild cognitively impaired (MCI) Aβ-negative (nMCI-=228), MCI Aβ-positive (nMCI+=193) and AD dementia Aβ-positive (nAD=113). CSF GAP-43 levels were increased in Aβ-positive compared to Aβ-negative participants, independent of the cognitive status. In Aβ-positive participants, high baseline GAP-43 levels led to worse brain metabolic decline (P=0.01), worse brain atrophy (P=8.8x10-27) as well as worse MMSE scores (P= 0.03) over time, as compared to those with low GAP-43 levels. Similarly, Aβ-positive participants with high baseline GAP-43 had the highest risk to convert to AD dementia (hazard ratio [HR=8.56, 95% CI, 4.94-14.80, P=1.5x10-14]). Despite the significant association with Aβ pathology (η 2 Aβ PET=0.09, P Aβ PET<0.001), CSF tTau and P-Tau had a larger effect size on GAP43 than had Aβ PET (η 2 pTau-181=0.53, P pTau-181<0.001; η 2 tTau=0.59, P tTau<0.001).and Classification of Evidence: This study provides Class III classification of evidence that high baseline levels of CSF GAP-43 are associated to progression in Aβ-positive individuals, with a more aggressive neurodegenerative process, faster rate of cognitive decline and increased risk of converting to dementia.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 51-53 av 53

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (49); forskningsöversikt (3)

Typ av innehåll: refereegranskat (51); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Shaw, Leslie M (48); Blennow, Kaj, 1958 (37); Trojanowski, John Q (32); Zetterberg, Henrik, ... (27); Andreasson, Ulf, 196 ... (12); Lewczuk, Piotr (11); visa fler...; Vanderstichele, Hugo (11); Hansson, Oskar (10); Portelius, Erik, 197 ... (9); Blennow, Kaj (8); Zetterberg, Henrik (8); Mattsson, Niklas, 19 ... (8); Hampel, Harald (7); Petersen, Ronald C. (7); Teunissen, Charlotte ... (6); Fagan, Anne M (6); Vandijck, Manu (6); Toledo, Jon B (6); Soares, Holly (6); Molinuevo, José Luis (5); Verbeek, Marcel M (5); Jeromin, Andreas (5); Grossman, Murray (5); Zegers, Ingrid (5); Carrillo, Maria C (5); Minthon, Lennart (4); Pannee, Josef, 1979 (4); Engelborghs, Sebasti ... (4); Parnetti, Lucilla (4); Teunissen, Charlotte (4); Schindler, Suzanne E ... (4); Bittner, Tobias (4); Elman, Lauren (4); Umek, Robert M (4); Albert, Marilyn (4); Otto, Markus (3); Jagust, William J. (3); Janelidze, Shorena (3); Stomrud, Erik (3); Ashton, Nicholas J. (3); Kvartsberg, Hlin, 19 ... (3); Mattsson, Niklas (3); Masters, Colin L (3); Bateman, Randall J (3); Ovod, Vitaliy (3); Insel, Philip S (3); Stoops, Erik (3); Eichenlaub, Udo (3); Bjerke, Maria, 1977 (3); Jack, Clifford R (3); visa färre...

Lärosäte: Göteborgs universitet (45); Lunds universitet (17); Uppsala universitet (2); Karolinska Institutet (2); Umeå universitet (1)

Språk: Engelska (53)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (51); Naturvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy