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  • Carslake, D, et al. (author)
  • Associations of parental age with offspring all-cause and cause-specific adult mortality
  • 2019
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 17097-
  • Journal article (peer-reviewed)abstract
    • People are having children later in life. The consequences for offspring adult survival have been little studied due to the need for long follow-up linked to parental data and most research has considered offspring survival only in early life. We used Swedish registry data to examine all-cause and cause-specific adult mortality (293,470 deaths among 5,204,433 people, followed up to a maximum of 80 years old) in relation to parental age. For most common causes of death adult survival was improved in the offspring of older parents (HR for all-cause survival was 0.96 (95% CI: 0.96, 0.97) and 0.98 (0.97, 0.98) per five years of maternal and paternal age, respectively). The childhood environment provided by older parents may more than compensate for any physiological disadvantages. Within-family analyses suggested stronger benefits of advanced parental age. This emphasises the importance of secular trends; a parent’s later children were born into a wealthier, healthier world. Sibling-comparison analyses can best assess individual family planning choices, but our results suggested a vulnerability to selection bias when there is extensive censoring. We consider the numerous causal and non-causal mechanisms which can link parental age and offspring survival, and the difficulty of separating them with currently available data.
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  • Result 91-100 of 170
Type of publication
journal article (155)
conference paper (8)
research review (1)
Type of content
peer-reviewed (143)
other academic/artistic (21)
Author/Editor
Smith, GD (85)
Uitterlinden, AG (30)
Martin, NG (29)
Hottenga, JJ (28)
Boomsma, DI (28)
Hofman, A (25)
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Hayward, C. (25)
Esko, T (23)
van Duijn, CM (22)
Ikram, MA (22)
Metspalu, A (22)
Montgomery, GW (21)
Lawlor, DA (21)
Polašek, O. (21)
Teumer, A (20)
Medland, SE (20)
Timpson, NJ (20)
Wilson, JF (20)
Willemsen, G (19)
Gudnason, V (19)
Deary, IJ (19)
Jarvelin, MR (19)
Rudan, I. (19)
Brenner, H (18)
Ferrucci, L (18)
Boerwinkle, E (18)
Campbell, H (18)
Gieger, C (18)
Spector, TD (18)
Kaprio, J (17)
Lee, M (17)
Psaty, BM (17)
Rivadeneira, F (17)
Hakonarson, H (17)
Martin, J. (16)
Khan, A. (16)
Amin, N (16)
Magnusson, PKE (16)
De Geus, EJC (16)
Jukema, JW (16)
Stefansson, K (16)
Brown, A. (15)
Tanaka, T. (15)
Pedersen, NL (15)
Smith, AV (15)
Launer, LJ (15)
Kumari, M (15)
Palotie, A (15)
Wareham, NJ (15)
Tynelius, P. (15)
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University
Karolinska Institutet (159)
Uppsala University (27)
Lund University (23)
University of Gothenburg (17)
Umeå University (8)
Stockholm University (6)
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Högskolan Dalarna (5)
Stockholm School of Economics (4)
Royal Institute of Technology (3)
Chalmers University of Technology (3)
Linköping University (2)
Swedish University of Agricultural Sciences (1)
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Language
English (170)
Research subject (UKÄ/SCB)
Medical and Health Sciences (53)
Natural sciences (16)
Agricultural Sciences (1)

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