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- Sun, Jiangwei, et al.
(författare)
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Risk of heart failure in inflammatory bowel disease : a Swedish population-based study
- 2024
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 45:28, s. 2493-2504
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Tidskriftsartikel (refereegranskat)abstract
- Background and Aims: Dysregulation of inflammatory and immune responses has been implicated in the pathogenesis of heart failure (HF). But even if inflammation is a prerequisite for inflammatory bowel disease (IBD), little is known about HF risk in IBD.Methods: In this Swedish nationwide cohort, patients with biopsy-confirmed IBD were identified between 1969 and 2017 [n = 81 749, Crohn's disease (CD, n = 24 303), ulcerative colitis (UC, n = 45 709), and IBD-unclassified (IBD-U, n = 11 737)]. Each patient was matched with up to five general population reference individuals (n = 382 190) and IBD-free full siblings (n = 95 239) and followed until 31 December 2019. Flexible parametric survival models estimated the adjusted hazard ratio (aHR) and standardized cumulative incidence for HF, with 95% confidence intervals (CI).Results: There were 5582 incident HF identified in IBD patients (incidence rate [IR]: 50.3/10 000 person-years) and 20 343 in reference individuals (IR: 37.9) during a median follow-up of 12.4 years. IBD patients had a higher risk of HF than reference individuals (aHR 1.19, 95% CI 1.15-1.23). This increased risk remained significant >= 20 years after IBD diagnosis, leading to one extra HF case per 130 IBD patients until then. The increased risk was also observed across IBD subtypes: CD (IR: 46.9 vs. 34.4; aHR 1.28 [1.20-1.36]), UC (IR: 50.1 vs. 39.7; aHR 1.14 [1.09-1.19]), and IBD-U (IR: 60.9 vs. 39.0; aHR 1.28 [1.16-1.42]). Sibling-controlled analyses showed slightly attenuated association (IBD: aHR 1.10 [1.03-1.19]).Conclusions: Patients with IBD had a moderately higher risk of developing HF for >= 20 years after IBD diagnosis than the general population.
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- Sundstrom, David, et al.
(författare)
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Recursive Spatial Covariance Estimation with Sparse Priors for Sound Field Interpolation
- 2023
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Ingår i: Proceedings of the 22nd IEEE Statistical Signal Processing Workshop, SSP 2023. - 9781665452458 ; 2023-July, s. 517-521
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Konferensbidrag (refereegranskat)abstract
- Recent advances have shown that sound fields can be accurately interpolated between microphone measurements when the spatial covariance matrix is known. This matrix may be estimated in various ways; one promising approach is to use a plane wave formulation with sparse priors, although this may require the use of a many microphones to suppress the noise. To overcome this, we introduce a time domain formulation exploiting multiple time samples, posing the problem as an identification problem of a recursively estimated sample covariance matrix. A computationally efficient method is proposed to solve the resulting identification problem. Using both numerical experiments and anechoic data, the proposed method is shown to yield preferable performance as compared to current state of the art methods, notably for high frequencies sources and/or in cases when using few microphones.
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- Sundstrom, Johan, et al.
(författare)
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Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality : prospective, population based cohort study
- 2006
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Ingår i: The BMJ. - 1756-1833. ; 332:7546, s. 878-882
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To find out if the presence of the metabolic syndrome increases the risk of subsequent total and cardiovascular mortality, taking into account established risk factors for cardiovascular disease. DESIGN: Prospective cohort study. SETTING: General population. PARTICIPANTS: A community based sample of 2322 men followed since 1970 for a maximum of 32.7 years, investigated at ages 50 and 70. MAIN OUTCOME MEASURES: The relations of the metabolic syndrome defined by the national cholesterol education programme (NCEP) of the US National Heart, Lung, and Blood Institute or criteria of the World Health Organization (WHO) to subsequent total and cardiovascular mortality. RESULTS: When adding the metabolic syndrome to models with established risk factors for cardiovascular disease (smoking, diabetes, hypertension, and serum cholesterol) at age 50, presence of the metabolic syndrome as defined in the NCEP significantly predicted total and cardiovascular mortality (Cox proportional hazard ratios 1.36, 95% confidence interval 1.17 to 1.58; and 1.59, 1.29 to 1.95, respectively). The metabolic syndrome added prognostic information to that of the established risk factors for cardiovascular disease (likelihood ratio tests, P < 0.0001 for both outcomes). Similar results were obtained in a subsample without diabetes or manifest cardiovascular disease. CONCLUSIONS: In a large, community based sample of middle aged men, the presence of the metabolic syndrome according to the definition of the NCEP gave long term prognostic information regarding total and cardiovascular mortality if the status of established risk factors for cardiovascular disease was known. If confirmed this may indicate clinical value in diagnosing the metabolic syndrome.
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