SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Sydow Olof) "

Sökning: WFRF:(Sydow Olof)

  • Resultat 21-22 av 22
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
21.
  • Westerlund, Marie, et al. (författare)
  • Association of a polymorphism in the ABCB1 gene with Parkinson's disease.
  • 2009
  • Ingår i: Parkinsonism & related disorders. - : Elsevier BV. - 1353-8020 .- 1873-5126. ; 15:6, s. 422-424
  • Tidskriftsartikel (refereegranskat)abstract
    • The ATP-binding cassette, sub-family B, member 1 (ABCB1) gene encoding the protein P-glycoprotein (P-gp) has been implicated in the pathophysiology of Parkinson's disease (PD) due to its role in regulating transport of endogenous molecules and exogenous toxins. In the present study, we analyzed the ABCB1 single nucleotide polymorphisms (SNPs) 1236C/T (exon 12), 2677G/T/A (exon 21) and 3435C/T (exon 26) in 288 Swedish PD patients and 313 control subjects and found a significant association of SNP 1236C/T with disease (p=0.0159; chi(2)=8.28), whereas the distributions of wild-type and mutated alleles were similar for 2677G/T/A and 3435C/T in patients and controls. Haplotype analysis revealed significant association of the 1236C-2677G haplotype with PD (p=0.026; chi(2)=4.955) and a trend towards association with disease of the 1236C-2677G-3435C haplotype (p=0.072; chi(2)=3.229). Altered ABCB1 and/or P-pg expression was recently shown in PD patients, and impaired drug efflux across barriers such as the gastrointestinal and nasal mucosal linings or the blood-brain barrier, might result in accumulation of drugs and/or endogenous molecules in toxic amounts, possibly contributing to disease. ABCB1 polymorphisms thus constitute an example of how genetic predisposition and environmental influences may combine to increase risk of PD.
  •  
22.
  • Westerlund, Marie, et al. (författare)
  • Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.
  • 2008
  • Ingår i: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - : Wiley. - 1530-6860. ; 22:10, s. 3509-14
  • Tidskriftsartikel (refereegranskat)abstract
    • Alterations of brain and plasma alpha-synuclein levels and SNCA gene variability have been implicated in the pathogenesis of Parkinson's disease (PD). We therefore measured alpha-synuclein protein levels in postmortem PD and control cerebellum tissue using Western blot and investigated whether the levels correlated to SNCA genotype. We found markedly decreased alpha-synuclein levels in PD patients (n=16) compared to gender- and age-matched controls (n=14; P=0.004) normalized to alpha-tubulin. We also performed an association study of the noncoding polymorphisms rs2737029 (A/G) and rs356204 (A/G) (intron 4), and of rs356219 (T/C) (3'-region) of SNCA in a Swedish PD case-control material. Using a two-sided chi(2) test, we found significant association of rs2737029 (P=0.003; chi(2)=9.07) and rs356204 (P=0.048; chi(2)=3.91) with disease, strengthening the involvement of SNCA polymorphisms in sporadic PD. Stratification of the human postmortem brain material by genotype of the three investigated polymorphisms, did not indicate any influence of genotype on alpha-synuclein protein levels when comparing PD with controls. Taken together, our findings demonstrate that the investigated Parkinson patients have markedly reduced levels of alpha-synuclein in cerebellum, and that this reduction is general, rather then correlated to the investigated polymorphisms, although two of the polymorphisms also associated with disease in a Swedish material.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 21-22 av 22
Typ av publikation
tidskriftsartikel (20)
bok (1)
doktorsavhandling (1)
Typ av innehåll
refereegranskat (19)
övrigt vetenskapligt/konstnärligt (3)
Författare/redaktör
Sydow, Olof (19)
Nissbrandt, Hans, 19 ... (15)
Olson, Lars (13)
Håkansson, Anna, 197 ... (12)
Westerlund, Marie (9)
Belin, Andrea Carmin ... (9)
visa fler...
Galter, Dagmar (8)
Johnels, Bo, 1940 (6)
Lind, Charlotta (6)
Westberg, Lars, 1973 (5)
Anvret, Anna (5)
Eriksson, Elias, 195 ... (4)
Ran, Caroline (4)
Bergman, Olle, 1978 (3)
Nilsson, Staffan, 19 ... (2)
Johansson, Anders (2)
Graff, Caroline (2)
Willows, Thomas (2)
Söderkvist, Peter (1)
Fratiglioni, Laura (1)
Nyholm, Dag (1)
Singleton, Andrew (1)
Winblad, Bengt (1)
Zettergren, Anna, 19 ... (1)
Ahmadi, Ahmad (1)
Dizdar (Dizdar Segre ... (1)
Söderkvist, Peter, 1 ... (1)
Hariz, Marwan (1)
Linder, Jan (1)
Svenningsson, Per (1)
Bäckman, Lars (1)
Ankarcrona, Maria (1)
Chrapkowska, Cecilia (1)
McMahon, Francis J (1)
von Sydow, Erik (1)
Bergmann, Lars (1)
Marshall, Thomas S. (1)
Blackinton, Jeff G (1)
Thelander, Ann-Chris ... (1)
Widner, Håkan (1)
Wittrock, Björn (1)
Melke, Jonas, 1971 (1)
Wüllner, Ullrich (1)
Widner, Hakan (1)
Petersson, Göran, 19 ... (1)
Ruin, Olof (1)
Behbahani, Homira (1)
Björk, Behnosh F (1)
Pernold, Karin (1)
Rosvall, Lina (1)
visa färre...
Lärosäte
Karolinska Institutet (19)
Göteborgs universitet (15)
Uppsala universitet (3)
Linköpings universitet (3)
Chalmers tekniska högskola (3)
Lunds universitet (1)
Språk
Engelska (21)
Svenska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (13)
Naturvetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy