| 71. |
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| 72. |
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| 73. |
- Skov, Vibe, et al.
(författare)
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A 7-gene signature depicts the biochemical profile of early prefibrotic myelofibrosis
- 2016
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:8
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have shown that a large proportion of patients classified as essential thrombocythemia (ET) actually have early primary prefibrotic myelofibrosis (prePMF), which implies an inferior prognosis as compared to patients being diagnosed with so-called genuine or true ET. According to theWorld Health Organization (WHO) 2008 classification, bone marrow histology is a major component in the distinction between these disease entities. However, the differential diagnosis between themmay be challenging and several studies have not been able to distinguish between them.Most lately, it has been argued that simple blood tests, including the leukocyte count and plasma lactate dehydrogenase (LDH) may be useful tools to separate genuine ET from prePMF, the latter disease entity more often being featured by anemia, leukocytosis and elevated LDH.Whole blood gene expression profiling was performed in 17 and 9 patients diagnosed with ET and PMF, respectively. Using elevated LDH obtained at the time of diagnosis as a marker of prePMF, a 7-gene signature was identified which correctly predicted the prePMF group with a sensitivity of 100%and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, andMMP8, which are genes known to be involved in inflammation, cell adhesion, differentiation and proliferation. Evaluation of bone marrow biopsies and the 7-gene signature showed a concordance rate of 71%, 79%, 62%, and 38%. Our 7-gene signature may be a useful tool to differentiate between genuine ET and prePMF but needs to be validated in a larger cohort of "ET" patients.
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| 74. |
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| 75. |
- Sundell, K., et al.
(författare)
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Novel Programs, International Adoptions, or Contextual Adaptations? : Meta-Analytical Results From German and Swedish Intervention Research
- 2016
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Ingår i: Journal of clinical child and adolescent psychology (Print). - : Routledge. - 1537-4416 .- 1537-4424. ; 45:6, s. 784-796
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Tidskriftsartikel (refereegranskat)abstract
- One of the major dilemmas in intervention and implementation research is adaptation versus adherence. High fidelity to an intervention protocol is essential for internal validity. At the same time, it has been argued that adaptation is necessary for improving the adoption and use of interventions by, for example, improving the match between an intervention and its cultural context, thus improving external validity. This study explores the origins of intervention programs (i.e., novel programs, programs adopted from other contexts with or without adaptation) in two meta-analytic intervention data sets from two European countries and compares the effect sizes of the outcomes of the interventions evaluated. Results are based on two samples of studies evaluating German child and youth preventative interventions (k = 158), and Swedish evaluations of a variety of psychological and social interventions (k = 139). The studies were categorized as novel programs, international adoption and contextual adaptation, with a total of six subcategories. In the German sample, after statistically controlling for some crucial methodological aspects, novel programs were significantly more effective than adopted programs. In the Swedish sample, a trend was found suggesting that adopted programs were less effective than adapted and novel programs. If these results are generalizable and unbiased, they favor novel and adapted programs over adopted programs with no adaptation and indicate that adoption of transported programs should not be done without considering adaptation.
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| 76. |
- Tafvelin, Susanne, 1975-, et al.
(författare)
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Leader-team perceptual distance affects outcomes of leadership training : Examining safety leadership and follower safety self-efficacy
- 2019
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Ingår i: Safety Science. - : Elsevier B.V.. - 0925-7535 .- 1879-1042. ; 120, s. 25-31
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Tidskriftsartikel (refereegranskat)abstract
- Whether leaders and their teams agree or not on perceptions of leadership has been found to impact follower well-being and performance. Less is known about how agreements or disagreements play a role in relation to safety and leadership training. The present study examined the effects of leaders’ and followers’ perceptual distance on safety leadership prior to a leadership safety training. Forty-eight leaders and a total of 211 followers from the paper industry completed surveys before and after training. Polynomial regression with response surface analyses revealed that the agreement between leaders and their followers regarding safety leadership before training was positively related to training outcomes including safety leadership and followers’ safety self-efficacy. Line managers who overrated themselves on safety leadership before training had less favorable training outcomes. Our findings suggest that 360-degree feedback may not be sufficient for motivating leaders to change their behaviors during leadership training.
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| 77. |
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| 78. |
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| 79. |
- von Thiele Schwarz, Ulrica, 1975-, et al.
(författare)
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Colliding ideals - An interview study of how intervention researchers address adherence and adaptations in replication studies
- 2018
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Ingår i: BMC Medical Research Methodology. - : BioMed Central Ltd.. - 1471-2288. ; 18:1
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Forskningsöversikt (refereegranskat)abstract
- Background: For an intervention to be considered evidence-based, findings need to be replicated. When this is done in new contexts (e.g., a new country), adaptations may be needed. Yet, we know little about how researchers approach this. This study aims to explore how researchers reason about adaptations and adherence when conducting replication studies, describe what adaptations they make and how these are reported in scientific journals. Methods: This was an interview study conducted in 2014 with principal investigators of Swedish replication studies reporting adaptations to an intervention from another country. Studies (n = 36) were identified through a database of 139 Swedish psychosocial and psychological intervention studies. Twenty of the 21 principal investigators agreed to participate in semi-structured telephone interviews, covering 33 interventions. Manifest content analysis was used to identify types of adaptations, and qualitative content analysis was used to explore reasoning and reporting of adaptations and adherence. Results: The most common adaptation was adding components and modifying the content to the target population and setting. When reasoning about adaptations and adherence, the researchers were influenced by four main factors: whether their implicit aim was to replicate or improve an intervention; the nature of evidence outlying the intervention such as manuals, theories and core components; the nature of the context, including approaches to cultural adaptations and constraints in delivering the intervention; and the needs of clients and professionals. Reporting of adaptations in scientific journals involved a conflict between transparency and practical concerns such as word count. Conclusions: Researchers responsible for replicating interventions in a new country face colliding ideals when trying to protect the internal validity of the study while considering adaptations to ensure that the intervention fits into the context. Implicit assumptions about the role of replication seemed to influence how this conflict was resolved. Some emphasised direct replications as central in the knowledge accumulation process (stressing adherence). Others assumed that interventions generally need to be improved, giving room for adaptations and reflecting an incremental approach to knowledge accumulation. This has implications for design and reporting of intervention studies as well as for how findings across studies are synthesised.
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| 80. |
- von Thiele Schwarz, Ulrica, 1975-, et al.
(författare)
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Complexity embraced : a new perspective on the evaluation of organisational interventions
- 2024
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Ingår i: Work & Stress. - : TAYLOR & FRANCIS LTD. - 0267-8373 .- 1464-5335.
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Tidskriftsartikel (refereegranskat)abstract
- Organisational interventions are recommended to address the root causes of ill-health in organisations. Yet, the evidence for their effectiveness is inconclusive, likely because such interventions are complex, and their effectiveness depends on how and in which contexts the interventions are implemented. This makes organisational interventions challenging to evaluate. While multiple factors affecting implementation and intervention outcomes have been uncovered, it remains unclear which of them are necessary and which are sufficient to produce desired outcomes. To move forward, we argue that the field would benefit from using a theory of causation that better reflects that factors can combine in various ways, that there may be multiple paths to the same outcome, and that a factor can be necessary for bringing about an outcome and thus always leads to it, or sufficient, implying that multiple factors can independently lead to the same outcome. We believe that the use of evaluation designs that align with this type of causation, such as the configurational comparative methods in general and coincidence analysis in particular, will be a significant turning point for the field. The proposed paradigm will improve the precision of current frameworks and models for the evaluation and implementation of organisational interventions.
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