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Numrering	Referens	Omslagsbild	Hitta
41.	Wain, Louise V., et al. (författare) Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney 2017 Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 70:3, s. e4-e19 Tidskriftsartikel (refereegranskat)abstract Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
42.	Williamson, Alice, et al. (författare) Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake 2023 Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:6, s. 973-983 Tidskriftsartikel (refereegranskat)abstract Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.
43.	Zillikens, M Carola, et al. (författare) Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 2017 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1 Tidskriftsartikel (refereegranskat)abstract A correction to this article has been published and is linked from the HTML version of this article.

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Typ av publikation: tidskriftsartikel (43)

Typ av innehåll: refereegranskat (42); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Tuomilehto, Jaakko (41); Wareham, Nicholas J. (33); Boehnke, Michael (32); Loos, Ruth J F (30); Salomaa, Veikko (29); Laakso, Markku (28); visa fler...; Mohlke, Karen L (28); McCarthy, Mark I (26); Langenberg, Claudia (26); Luan, Jian'an (26); Kuusisto, Johanna (25); Lind, Lars (24); Gieger, Christian (24); Barroso, Ines (24); Metspalu, Andres (24); Groop, Leif (23); Thorleifsson, Gudmar (23); Stefansson, Kari (23); Palmer, Colin N. A. (23); Gudnason, Vilmundur (23); Perola, Markus (22); Rudan, Igor (22); Deloukas, Panos (22); Hayward, Caroline (22); van Duijn, Cornelia ... (21); Thorsteinsdottir, Un ... (21); Harris, Tamara B (21); Hofman, Albert (21); Morris, Andrew D (21); Boerwinkle, Eric (21); Frayling, Timothy M (21); Hansen, Torben (20); Peters, Annette (20); Froguel, Philippe (20); Ridker, Paul M. (19); Chasman, Daniel I. (19); Wilson, James F. (19); Uitterlinden, André ... (19); Elliott, Paul (19); Illig, Thomas (19); Campbell, Harry (18); Pedersen, Oluf (18); Scott, Robert A (18); Ingelsson, Erik (18); Rotter, Jerome I. (18); Mangino, Massimo (18); Hattersley, Andrew T (18); Mahajan, Anubha (18); Munroe, Patricia B. (18); Prokopenko, Inga (18); visa färre...

Lärosäte: Lunds universitet (34); Uppsala universitet (32); Karolinska Institutet (24); Umeå universitet (23); Göteborgs universitet (11); Stockholms universitet (5); visa fler...; Högskolan Dalarna (3); Luleå tekniska universitet (2); Handelshögskolan i Stockholm (1); visa färre...

Språk: Engelska (43)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (41); Naturvetenskap (8)

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