| 581. |
- Ignatyuk, A. V., et al.
(författare)
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Neutron cross-section evaluations for U-238 up to 150 MeV
- 2000
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Ingår i: Nuclear science and engineering. - 0029-5639 .- 1943-748X. ; 136:3, s. 340-356
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Tidskriftsartikel (refereegranskat)abstract
- Investigations aimed at the development of neutron cross-section evaluations for U-238 at intermediate energies are briefly described. The coupled-channels optical model is used to calculate the neutron total, the elastic and reaction cross sections, and the elastic-scattering angular distributions. Evaluations of the neutron and charged particle emission cross sections and of the fission cross sections are obtained on the basis of the statistical description that includes direct, preequilibrium, and equilibrium mechanisms of nuclear reactions. The Kalbach parameterization of angular distributions is used to describe the double-differential cross sections of emitted neutrons and charged particles in ENDF/B-VI format.
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| 582. |
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| 583. |
- Kisiel, Marta, et al.
(författare)
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Critical assessment of rhBMP-2 mediated bone induction : An in vitro and in vivo evaluation.
- 2012
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Ingår i: Journal of Controlled Release. - : Elsevier BV. - 0168-3659 .- 1873-4995. ; 162:3, s. 646-653
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Tidskriftsartikel (refereegranskat)abstract
- Understanding the influence of formulation and storage conditions on rhBMP-2 bioactivity is extremely important for its clinical application. Reports in the literature show that different research groups employ different parameters such as formulation conditions, storage, doses for in vivo applications etc. that makes it difficult to correlate results from different experiments. We therefore decided to rationalize these anomalies by performing a basic study on such parameters using two commercially available BMPs. Our in vitro experiments suggest that BMPs from different sources have significant differences in their bioactivity. The clinically approved rhBMP-2 (InductOs®; BMP-P) showed superior stability, compared to rhBMP-2 from R&D Systems (BMP-R) at physiological pH (determined by ALP assay). This BMP-P also showed lower binding to polypropylene Eppendorf tube. The BMP-R almost lost its bioactivity within 30min at physiological pH and also shows more adhesion to plastic surfaces. This aggregation behavior was unequivocally ascertained by performing light scattering studies of the two BMPs, which revealed linear aggregation with time for BMP-R unlike BMP-P. The in vitro results were also reflected in the in vivo experiments, in a rat ectopic model with injectable hyaluronic acid (HA) hydrogel as BMP carrier. After 7weeks post-implantation we observed larger bone volume with oriented collagen in the BMP-P group but a smaller bone with disoriented collagen in the BMP-R case. Our results highlight the large difference in activity between seemingly identical substances and also the importance of proper handling of such sensitive proteins.
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| 584. |
- Lissing, M, et al.
(författare)
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Liver Transplantation for Acute Intermittent Porphyria
- 2021
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Ingår i: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. - : Ovid Technologies (Wolters Kluwer Health). - 1527-6473. ; 27:4, s. 491-501
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Tidskriftsartikel (refereegranskat)
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| 585. |
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| 586. |
- Marini, E., et al.
(författare)
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Characterization of M-stars in the LMC in the JWST era
- 2020
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Abeysekara. - 0035-8711 .- 1365-2966. ; 493:2, s. 2996-3013
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Tidskriftsartikel (refereegranskat)abstract
- We study the M-type asymptotic giant branch (AGB) population of the Large Magellanic Cloud (LMC) by characterizing the individual sources in terms of the main properties of the progenitors and of the dust present in the circumstellar envelope. To this aim we compare the combination of the spectroscopic and photometric data collected by Spitzer, complemented by additional photometric results available in the literature, with results from AGB modelling that include the description of dust formation in the wind. To allow the interpretation of a paucity stars likely evolving through the post-AGB phase, we extended the available evolutionary sequences to reach the PN phase. The main motivation of the present analysis is to prepare the future observations of the evolved stellar populations of Local Group galaxies that will be done by the James Webb Space Telescope (JWST), by identifying the combination of filters that will maximize the possibilities of characterizing the observed sources. The present results show that for the M-star case the best planes to be used for this purpose are the colour magnitude ([F770W]-[F2550W], [F770W]) and (K-S-[F770W], [F770W]) planes. In these observational diagrams the sequences of low-mass stars evolving in the AGB phases before the achievement of the C-star stage and of massive AGBs experiencing hot bottom burning are clearly separated and peculiar sources, such as post-AGB, dual-dust chemistry, and iron-dust stars can be easily identified.
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| 587. |
- Marini, E., et al.
(författare)
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The intense production of silicates during the final AGB phases of intermediate mass stars
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 670
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Tidskriftsartikel (refereegranskat)abstract
- Context. The formation of silicates in circumstellar envelopes of stars evolving through the asymptotic giant branch (AGB) is still highly debated given the uncertainties affecting stellar evolution modelling, the description of the dust formation process, and the capability of silicate grains to accelerate stellar outflows via radiation pressure.Aims. We study the formation of dust in the winds of intermediate mass (M ≥ 4 M⊙) stars of solar metallicity while evolving through the AGB phase. We tested the different treatments of the mass-loss mechanism by this class of stars, with the aim of assessing their contribution to the general enrichment of silicates of the interstellar medium of galaxies and, on more general grounds, to the silicates budget of the Universe.Methods. We consider a sub-sample of AGB stars, whose spectral energy distribution (SED) is characterised by deep absorption features at 10 μm and 18 μm, which can be regarded as the class of stars providing the most relevant contribution to the silicates’ production across the Universe. Results from stellar evolution and dust formation modelling were used to fit the observed SED and to reproduce, at the same time, the detected pulsation periods and the derived surface chemical composition. This analysis leads to the derivation of tight constraints on the silicates’ production rates experienced by these sources during the final AGB stages.Results. Two out of the four sources investigated are interpreted as stars currently undergoing hot bottom burning (HBB), evolving through phases close to the stage when the mass-loss rate is largest. The remaining two stars are likely evolving through the very final AGB phases, after HBB was turned off by the gradual consumption of the convective mantle. Mass-loss rates of the order of 1 × 10−4 M⊙ yr−1 to 2 × 10−4 M⊙ yr−1 are required when looking for consistency with the observational evidence. These results indicate the need for a revision of the silicate yields by intermediate mass stars, which are found to be ∼3 times higher than previously determined.
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| 588. |
- Marini, E., et al.
(författare)
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Understanding the evolution and dust formation of carbon stars in the Large Magellanic Cloud via the JWST
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 647
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Tidskriftsartikel (refereegranskat)abstract
- Context. Carbon stars have been, and still are, extensively studied. Given their complex internal structure and their peculiar chemical composition, they are living laboratories in which we can test stellar structure and evolution theories of evolved stars. Furthermore, they are the most relevant dust manufacturers, thus playing a crucial role in the evolution of galaxies. Aims. We aim to study the dust mineralogy of the circumstellar envelope of carbon stars in the Large Magellanic Cloud (LMC) to achieve a better understanding of the dust formation process in the outflow of these objects. We intend to investigate the expected distribution of carbon stars in the observational planes built with the filters of the Mid-Infrared Instrument (MIRI) mounted onboard the James Webb Space Telescope (JWST) to select the best planes allowing an exhaustive characterisation of the stars. Methods. We compared the synthetic spectral energy distributions, obtained by modelling asymptotic giant branch stars and the dust formation process in the wind, with the spectra of carbon stars in the LMC, taken with the Infrared Spectrograph onboard the Spitzer Space Telescope. From the detailed comparison between synthetic modelling and observation we characterise the individual sources and derive the detailed mineralogy of the dust in the circumstellar envelope. Results. The sample of stars considered here is composed of stars of diverse mass, formation epoch, degree of obscuration, and metallicity. We find that precipitation of MgS on SiC seeds is common to all non-metal-poor carbon stars. Solid carbon is the dominant dust component, with percentages above 80% in all cases; a percentage between 10% and 20% of carbon dust is under the form of graphite, the remaining being amorphous carbon. Regarding the observational planes based on the MIRI filters, the colour-magnitude ([F770W]-[F1800W], [F1800W]) plane allows the best understanding of the degree of obscuration of the stars, while the ([F1800W]- [F2550W], [F1800W]) diagram allows better discrimination among stars of different metallicities.
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| 589. |
- Mattsson, Lars, et al.
(författare)
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Improved implementation of dust-driven winds and dust formation in models of AGB evolution : Effects of pulsation and gas-pressure forcing
- 2017
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Ingår i: Memorie della Societa Astronomica Italiana - Journal of the Italian Astronomical Society. - : Societa Astronomica Italiana. ; , s. 389-392
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Konferensbidrag (refereegranskat)abstract
- Mass loss is a crucial component in stellar evolution models, since it largely determines the rate of evolution at the later stages of a star’s life. The dust-driven outflows from AGB stars are particularly important in this regard. Including AGB dust formation in a stellar evolution model does also require a model of these outflows. Since AGB stars exhibit large-amplitude pulsation, a model based on time-dependent radiation hydrodynamics (RHD) is needed in order to capture all the important physical aspects of dust formation. However, this cannot be afforded in a stellar evolution model. Here, a mean-flow model is presented, which include corrections to the steady-state model currently being used in AGB evolution models with dust formation.
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| 590. |
- Maurer, Mathew S., et al.
(författare)
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Genotype and Phenotype of Transthyretin Cardiac Amyloidosis THAOS (Transthyretin Amyloid Outcome Survey)
- 2016
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 68:2, s. 161-172
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Tidskriftsartikel (refereegranskat)abstract
- Background: Transthyretin amyloidosis (ATTR) is a heterogeneous disorder with multiorgan involvement and a genetic or nongenetic basis.Objectives: The goal of this study was to describe ATTR in the United States by using data from the THAOS (Transthyretin Amyloidosis Outcomes Survey) registry.Methods: Demographic, clinical, and genetic features of patients enrolled in the THAOS registry in the United States (n = 390) were compared with data from patients from other regions of the world (ROW) (n = 2,140). The focus was on the phenotypic expression and survival in the majority of U.S. subjects with valine-to-isoleucine substitution at position 122 (Val122Ile) (n = 91) and wild-type ATTR (n = 189).Results: U.S. subjects are older (70 vs. 46 years), more often male (85.4% vs. 50.6%), and more often of African descent (25.4% vs. 0.5%) than the ROW. A significantly higher percentage of U.S. patients with ATTR amyloid seen at cardiology sites had wild-type disease than the ROW (50.5% vs. 26.2%). In the United States, 34 different mutations (n = 201) have been reported, with the most common being Val122Ile (n = 91; 45.3%) and Thr60Ala (n = 41; 20.4%). Overall, 91 (85%) of 107 patients with Val122Ile were from the United States, where Val122Ile subjects were younger and more often female and black than patients with wild-type disease, and had similar cardiac phenotype but a greater burden of neurologic symptoms (pain, numbness, tingling, and walking disability) and worse quality of life. Advancing age and lower mean arterial pressure, but not the presence of a transthyretin mutation, were independently associated with higher mortality from a multivariate analysis of survival.Conclusions: In the THAOS registry, ATTR in the United States is overwhelmingly a disorder of older adult male subjects with a cardiac-predominant phenotype. Val122Ile is the most common transthyretin mutation, and neurologic phenotypic expression differs between wild-type disease and Val122Ile, but survival from enrollment in THAOS does not. (Transthyretin-Associated Amyloidoses Outcome Survey [THAOS]; NCT00628745)
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