| 321. |
- Guirado, J. C., et al.
(författare)
-
VLTI/AMBER detection of a K=9.5 very low mass star
- 2013
-
Ingår i: Memorie della Societa Astronomica Italiana. ; 84:4, s. 1044-
-
Konferensbidrag (refereegranskat)abstract
- The precise determination of both the dynamical mass and infrared photometry of the close companion to AB Dor A, AB Dor C (0.090 solar masses), has provided an important benchmark for calibration of theoretical evolutionary models of low-mass young stars. However, comparison of the observed magnitudes of AB Dor C with these models suggests that they could overpredict the flux of this object, a trend also found in other young systems. One of the ambiguities remaining in AB Dor C is the possible binary nature of this star; in fact, should AB Dor C be close binary (about 10 mas separation), it could reconcile observations and models. We will report on VLTI/AMBER observations of AB Dor C addressed to discriminate between both scenarios: AB Dor C as a single object or a binary brown dwarf. We used a non-standard "off-axis" fringe tracking that allowed the detection of AB Dor C. This is, to our knowledge, one of the weakest objects detected by an infrared interferometer (Ks=9.5).
|
|
| 322. |
- Hodgson, J.A., et al.
(författare)
-
Location of γ-ray emission and magnetic field strengths in OJ 287
- 2017
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 597, s. 80-
-
Tidskriftsartikel (refereegranskat)abstract
- Context. The γ-ray BL Lac object OJ 287 is known to exhibit inner-parsec "jet-wobbling", high degrees of variability at all wavelengths and quasi-stationary features, including an apparent (≈100°) position-angle change in projection on the sky plane. Aims. Sub-50 micro-arcsecond resolution 86 GHz observations with the global mm-VLBI array (GMVA) supplement ongoing multifrequency VLBI blazar monitoring at lower frequencies. Using these maps, together with cm/mm total intensity and γ-ray observations from Fermi-LAT from 2008..2014, we aim to determine the location of γ-ray emission and to explain the inner-mas structural changes. Methods. Observations with the GMVA oer approximately double the angular resolution compared with 43 GHz VLBA observations and enable us to observe above the synchrotron self-absorption peak frequency. Fermi-LAT γ-ray data were reduced and analysed. The jet was spectrally decomposed at multiple locations along the jet. From this, we could derive estimates of the magnetic field using equipartition and synchrotron self-absorption arguments. How the field decreases down the jet provided an estimate of the distance to the jet apex and an estimate of the magnetic field strength at the jet apex and in the broad line region. Combined with accurate kinematics, we attempt to locate the site of γ-ray activity, radio flares, and spectral changes. Results. Strong γ-ray flares appeared to originate from either the so-called core region, a downstream stationary feature, or both, with γ-ray activity significantly correlated with radio flaring in the downstream quasi-stationary feature. Magnetic field estimates were determined at multiple locations along the jet, with the magnetic field found to be ≥1.6G in the core and ≤0.4G in the downstream quasi-stationary feature.We therefore found upper limits on the location of the VLBI core as ≤6.0 pc from the jet apex and determined an upper limit on the magnetic field near the jet base of the order of thousands of Gauss.
|
|
| 323. |
|
|
| 324. |
- Horejs, CM, et al.
(författare)
-
Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
- 2017
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8, s. 15509-
-
Tidskriftsartikel (refereegranskat)abstract
- Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed an electrospun membrane biofunctionalized with a fragment of the laminin β1-chain to modulate the expression of MMP2 in this context. We demonstrate that interfacing of the β1-fragment with the mesothelium of the peritoneal membrane via a biomaterial abrogates the release of active MMP2 in response to transforming growth factor β1 and rescues tissue integrity ex vivo and in vivo in a mouse model of peritoneal fibrosis. Importantly, our data demonstrate that the membrane inhibits MMP2 expression. Changes in the expression of epithelial-to-mesenchymal transition (EMT)-related molecules further point towards a contribution of the modulation of EMT. Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations of current therapeutic approaches by enabling a localized and specific method to counteract MMP2 release applicable to a broad range of therapeutic targets.
|
|
| 325. |
|
|
| 326. |
|
|
| 327. |
- Jannasch, Franziska, et al.
(författare)
-
Associations between exploratory dietary patterns and incident type 2 diabetes : a federated meta-analysis of individual participant data from 25 cohort studies.
- 2022
-
Ingår i: European Journal of Nutrition. - : Springer Nature. - 1436-6207 .- 1436-6215. ; 61:7, s. 3649-3667
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: In several studies, exploratory dietary patterns (DP), derived by principal component analysis, were inversely or positively associated with incident type 2 diabetes (T2D). However, findings remained study-specific, inconsistent and rarely replicated. This study aimed to investigate the associations between DPs and T2D in multiple cohorts across the world.METHODS: This federated meta-analysis of individual participant data was based on 25 prospective cohort studies from 5 continents including a total of 390,664 participants with a follow-up for T2D (3.8-25.0 years). After data harmonization across cohorts we evaluated 15 previously identified T2D-related DPs for association with incident T2D estimating pooled incidence rate ratios (IRR) and confidence intervals (CI) by Piecewise Poisson regression and random-effects meta-analysis.RESULTS: 29,386 participants developed T2D during follow-up. Five DPs, characterized by higher intake of red meat, processed meat, French fries and refined grains, were associated with higher incidence of T2D. The strongest association was observed for a DP comprising these food groups besides others (IRRpooled per 1 SD = 1.104, 95% CI 1.059-1.151). Although heterogeneity was present (I2 = 85%), IRR exceeded 1 in 18 of the 20 meta-analyzed studies. Original DPs associated with lower T2D risk were not confirmed. Instead, a healthy DP (HDP1) was associated with higher T2D risk (IRRpooled per 1 SD = 1.057, 95% CI 1.027-1.088).CONCLUSION: Our findings from various cohorts revealed positive associations for several DPs, characterized by higher intake of red meat, processed meat, French fries and refined grains, adding to the evidence-base that links DPs to higher T2D risk. However, no inverse DP-T2D associations were confirmed.
|
|
| 328. |
- Jansen, Iris E, et al.
(författare)
-
Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.
- 2022
-
Ingår i: Acta neuropathologica. - : Springer Science and Business Media LLC. - 1432-0533 .- 0001-6322. ; 144:5, s. 821-842
-
Tidskriftsartikel (refereegranskat)abstract
- Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple Aβ42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.
|
|
| 329. |
- Jaud, Simon, et al.
(författare)
-
Insertion of short transmembrane helices by the Sec61 translocon
- 2009
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:28, s. 11588-11593
-
Tidskriftsartikel (refereegranskat)abstract
- The insertion efficiency of transmembrane (TM) helices by the Sec61 translocon depends on helix amino acid composition, the positions of the amino acids within the helix, and helix length. We have used an in vitro expression system to examine systematically the insertion efficiency of short polyleucine segments (L(n), n = 4 ... 12) flanked at either end by 4-residue sequences of the form XXPX-L(n)-XPXX with X = G, N, D, or K. Except for X = K, insertion efficiency (p) is <10% for n < 8, but rises steeply to 100% for n = 12. For X = K, p is already close to 100% for n = 10. A similar pattern is observed for synthetic peptides incorporated into oriented phospholipid bilayer arrays, consistent with the idea that recognition of TM segments by the translocon critically involves physical partitioning of nascent peptide chains into the lipid bilayer. Molecular dynamics simulations suggest that insertion efficiency is determined primarily by the energetic cost of distorting the bilayer in the vicinity of the TM helix. Very short lysine-flanked leucine segments can reduce the energetic cost by extensive hydrogen bonding with water and lipid phosphate groups (snorkeling) and by partial unfolding.
|
|
| 330. |
- Jaworski, G., et al.
(författare)
-
The New Neutron Multiplicity Filter NEDA and Its First Physics Campaign with AGATA
- 2019
-
Ingår i: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 50:3, s. 585-590
-
Tidskriftsartikel (refereegranskat)abstract
- A new neutron multiplicity filter NEDA, after a decade of design, R&D and construction, was employed in its first physics campaign with the AGATA spectrometer. Properties and performance of the array are discussed.
|
|
