| 1671. |
- Kren, F., et al.
(författare)
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Exclusive measurements of pp -> d pi(+)pi(0) : Double-pionic fusion without ABC effect
- 2010
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 684:2-3, s. 110-113
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Tidskriftsartikel (refereegranskat)abstract
- Exclusive measurements of the reaction pp -> d pi(+)pi(0) have been carried out at T-p = 1.1 GeV at the CELSIUS storage ring using the WASA detector. The isovector pi(+)pi(0) channel exhibits no enhancement at low invariant pi pi masses, i.e. no ABC effect. Therefore this most basic isovector double-pionic fusion reaction qualifies as an ideal test case for the conventional t-channel Delta Delta excitation process. Indeed, the obtained differential distributions reveal the conventional t-channel Delta Delta mechanism as the appropriate reaction process, which also accounts for the observed energy dependence of the total cross section.
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| 1672. |
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| 1673. |
- Krones, E., et al.
(författare)
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NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated mice
- 2017
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Ingår i: Journal of Hepatology. - : Elsevier BV. - 0168-8278. ; 67:1, s. 110-119
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Tidskriftsartikel (refereegranskat)abstract
- Background & Aims: Severe cholestasis may cause cholemic nephropathy that can be modeled in common bile duct ligated (CBDL) mice. We aimed to explore the therapeutic efficacy and mechanisms of norursodeoxycholic acid (norUDCA) in cholemic nephropathy. Methods: In 8-week CBDL mice fed with norUDCA (prior or post CBDL) or chow we evaluated serum urea levels, urine cytology and urinary neutrophil gelatinase associated lipocalin (uNGAL), kidney and liver tissue quantification of fibrosis by hydroxyproline content and gene chip expression looking at key genes of inflammation and fibrosis. Moreover, we comprehensively analysed bile acid profiles in liver, kidney, serum and urine samples. Results: NorUDCA-fed CBDL mice had significantly lower serum urea and uNGAL levels and less severe cholemic nephropathy as demonstrated by normal urine cytology, significantly reduced tubulointerstitial nephritis, and renal fibrosis as compared to controls. NorUDCA underwent extensive metabolism to produce even more hydrophilic compounds that were significantly enriched in kidneys. Conclusion: NorUDCA ameliorates cholemic nephropathy due to the formation of highly hydrophilic metabolites enriched in kidney. Consequently, norUDCA may represent a medical treatment for cholemic nephropathy. Lay summary: The term cholemic nephropathy describes renal dysfunction together with characteristic morphological alterations of the kidney in obstructive cholestasis that can be mimicked by ligation of the common bile duct in mice. Feeding the hydrophilic bile acid norUDCA to bile duct ligated mice leads to a significant amelioration of the renal phenotype due to the formation of highly hydrophilic metabolites enriched in the kidney and may therefore represent a medical treatment for cholemic nephropathy. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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| 1674. |
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| 1675. |
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| 1676. |
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| 1677. |
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| 1678. |
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| 1679. |
- Kögler, T., et al.
(författare)
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Fast-neutron-induced fission cross section of Pu 242 measured at the neutron time-of-flight facility nELBE
- 2019
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Ingår i: Physical Review C. - 2469-9985. ; 99:2
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Tidskriftsartikel (refereegranskat)abstract
- The fast-neutron-induced fission cross section of Pu242 was measured at the neutron time-of-flight facility nELBE. A parallel-plate fission ionization chamber with novel, homogeneous, large-area Pu242 deposits on Si-wafer backings was used to determine this quantity relative to the IAEA neutron cross-section standard U235(n,f) in the energy range of 0.5 to 10 MeV. The number of target nuclei was determined from the measured spontaneous fission rate of Pu242. This helps to reduce the influence of the fission fragment detection efficiency on the cross section. Neutron transport simulations performed with geant4, mcnp6, and fluka2011 are used to correct the cross-section data for neutron scattering. In the reported energy range the systematic uncertainty is below 2.7% and on average the statistical uncertainty is 4.9%. The determined results show an agreement within 0.67(16)% to recently published data and a good accordance to current evaluated data sets.
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| 1680. |
- Lam, Anny, et al.
(författare)
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The classical versus the Cabrera presentation system for resting electrocardiography: Impact on recognition and understanding of clinically important electrocardiographic changes.
- 2015
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Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 1532-8430 .- 0022-0736. ; 48:4, s. 476-482
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Forskningsöversikt (refereegranskat)abstract
- The classical system for presentation of the 12-lead electrocardiogram (ECG) reflects the electrical activity of the heart as viewed in the transverse plane by 6 leads with a single anatomically ordered sequence, V1-V6; but in the frontal plane by 6 leads with dual sequences, I, II, and III, and aVR, aVL, and aVF. However, there is also a single anatomically ordered sequence of leads, called the Cabrera display that presents the six frontal plane leads in their anatomically ordered sequence of: aVL, I, -aVR, II, aVF, and III. Although it has been recognized that the Cabrera system has clinical diagnostic advantages compared to the classical display, it is currently only used in Sweden. The primary explanation of why the Cabrera system has not been adopted internationally has been that analog ECG recorders had technical limitations. Currently, however, the classical system is most often seen as a historical remnant that prevails because of conservatism within the cardiology community.
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