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31.	He, YQ, et al. (author) A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening 2022 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 1966- Journal article (peer-reviewed)abstract Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.65) and improves the risk prediction with the PRS incremental deciles in each population (Ptrend ranging from 2.79 × 10−7 to 4.79 × 10−44). By incorporating the PRS into EBV-serology-based NPC screening, the test’s positive predictive value (PPV) is increased from an average of 4.84% to 8.38% and 11.91% in the top 10% and 5% PRS, respectively. In summary, the GWAS-derived PRS, together with the EBV test, significantly improves NPC risk stratification and informs personalized screening.
32.	James, SL, et al. (author) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 2018 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 392:10159, s. 1789-1858 Journal article (peer-reviewed)
33.	Kyu, HH, et al. (author) Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 2018 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 392:10159, s. 1859-1922 Journal article (peer-reviewed)
34.	Li, J, et al. (author) Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction 2018 In: Human reproduction (Oxford, England). - : Oxford University Press (OUP). - 1460-2350 .- 0268-1161. ; 33:4, s. 617-625 Journal article (peer-reviewed)
35.	Shrine, N, et al. (author) Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk 2023 In: Nature genetics. - 1546-1718. ; 55:10, s. 1778-1779 Journal article (other academic/artistic)
36.	Shrine, N, et al. (author) Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk 2023 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 55:3, s. 410- Journal article (peer-reviewed)abstract Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.
37.	Siddiq, A, et al. (author) A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11 2012 In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 21:24, s. 5373-5384 Journal article (peer-reviewed)
38.	Skibola, CF, et al. (author) Meta-analysis of genome-wide association studies identifies novel susceptibility loci for follicular lymphoma 2014 In: CANCER RESEARCH. - 0008-5472. ; 74:19 Conference paper (other academic/artistic)
39.	Vijai, J, et al. (author) A genome-wide association study suggests evidence of variants at 6p21.32 associated with marginal zone lymphoma 2014 In: CANCER RESEARCH. - 0008-5472. ; 74:19 Conference paper (other academic/artistic)
40.	Wang, H, et al. (author) Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studies in vivo and in vitro 2017 In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:57, s. 96604-96614 Journal article (peer-reviewed)

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Result 31-40 of 116

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Type of publication: journal article (104); conference paper (11); research review (1)

Type of content: peer-reviewed (100); other academic/artistic (16)

Author/Editor: Chanock, SJ (26); Chen, ZM (23); Jonas, JB (22); Brenner, H (20); Zhang, L. (19); Peters, A (19); show more...; Khang, YH (18); Lehtimaki, T. (18); Zheng, W. (17); Farzadfar, F (17); Gudnason, V (17); Malekzadeh, R (16); Riboli, E. (16); Wang, Q. (16); He, J (16); Djalalinia, S (15); Lotufo, PA (15); Sepanlou, SG (15); Silva, DAS (15); Lee, J. (15); Vollenweider, P. (15); Gupta, R. (14); Kim, J. (14); Zhang, B. (14); Khader, YS (14); Shibuya, K (14); Shiri, R (14); Topor-Madry, R (14); Kaaks, R. (14); Lin, X. (14); Ma, J (14); Ikram, MA (14); Vineis, P (14); Chen, L (13); Xu, L. (13); Liu, J. (13); Zhang, Y. (13); Mohammadifard, N (13); Sarrafzadegan, N (13); Fischer, K. (13); Wang, YT (13); Wu, SL (13); Cheng, CY (13); Wong, TY (13); Jiang, X. (13); Haiman, CA (13); Le Marchand, L (13); Cooper, C. (13); Marques-Vidal, P. (13); Muller-Nurasyid, M. (13); show less...

University: Karolinska Institutet (113); Lund University (30); Uppsala University (24); Umeå University (15); University of Gothenburg (14); Högskolan Dalarna (8); show more...; University of Skövde (5); Chalmers University of Technology (4); Royal Institute of Technology (2); Stockholm University (2); Linköping University (2); Stockholm School of Economics (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (116)

Research subject (UKÄ/SCB): Medical and Health Sciences (44); Natural sciences (4); Social Sciences (1)

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