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Sökning: WFRF:(Wiman B)

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31.
  • Bennet, A. M., et al. (författare)
  • Association of TNF-α serum levels and TNFA promoter polymorohisms with risk of myocardial infarction
  • 2006
  • Ingår i: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 187:2, s. 408-414
  • Tidskriftsartikel (refereegranskat)abstract
    • Elevated levels of tumor necrosis factor-alpha (TNF-α), and presence of polymorphisms of the TNFA gene have been implicated in cardiovascular disease pathogenesis. We explored the relationship between polymorphisms in the TNFA gene (−1031C/T, −863C/A −857T/C, −308G/A, −238G/A), protein levels of TNF-α and their association to myocardial infarction (MI) using a sample of 1213 post-MI patients and 1561 healthy controls. MI risk was higher among men with elevated TNF-α levels, with the highest compared to the lowest TNF-α quartile giving a 70% risk increase (OR [95% CI]: 1.7 [1.1; 2.6]). Obese subjects who also had elevated TNF-α levels were at even higher risk for MI (OR [95% CI]: 3.4 [2.1; 5.6]). Higher TNF-α levels were seen among smokers (but not among non-smokers) carrying the −857T allele. Furthermore, a rare haplotype occurred more frequently among the cases than the controls. Elevated TNF-α levels are associated with increased MI risk. Obese subjects with elevated TNF-a levels, and carriers of polymorphisms in or near TNFA are particularly susceptible to the hazards of smoking, results which may have implications for cardiovascular preventive measures.
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35.
  • Bruun-Lundgren, Maria, 1949, et al. (författare)
  • Industrial activities and personal adornments
  • 2000
  • Ingår i: The Greek-Swedish excavations at the Agia Aikaterini Square, Kastelli, Khania 1970-1987 : results of the excavations under the direction of Yannis Tzedakis and Carl-Gustaf Styrenius. Vol. 2, The Late Minoan IIIC settlement : text and plates. - 9179160417 ; 2, s. 175-183
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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40.
  • Enckell, P H, et al. (författare)
  • The dispersal pattern of an anthropochorous species: Genetic variation in populations of Lumbricus terrestris L. (Lumbricidae) in the Faroe Islands
  • 1986
  • Ingår i: Hereditas. - : Springer Science and Business Media LLC. - 0018-0661 .- 1601-5223. ; 104:2, s. 253-261
  • Tidskriftsartikel (refereegranskat)abstract
    • Ten populations of the anthropochorous Lumbricus terrestris L. (Lumbricidae) from six islands in the Faroes were scored for enzyme variation by electrophoresis. The allele frequencies were analyzed by cluster analysis and information entropy relationships. There was a significant heterogeneity in allele frequencies among the samples. Four groups could be distinguished in the cluster analysis of which one was larger (at least five sites); two sites were defined as outliers. Information entropy showed that the allele frequency data were structured differently over the sites and that the most non-random site was also one of the outliers in the cluster space. The main group in the cluster analysis also forms a geographically central group in the islands. These results are discussed against the known colonization history of the Faroes. It is concluded that the genetic variation pattern does not indicate any single point of invasion of L. terrestris into the islands. Rather, it shows that former and present-day communications between the islands are responsible for similarities and dissimilarities in genetic variation in the L. terrestris populations. 
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