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Sökning: WFRF:(Wiman B)

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41.
  • Evgenieva, Tsvetina, et al. (författare)
  • Lidar, ceilometer and sun photometer investigation of the aerosol optical characteristics in the troposphere over Sofia, Bulgaria
  • 2010
  • Ingår i: Comptes Rendus de l'Academie Bulgare des Sciences / Proceedings of the Bulgarian Academy of Sciences. - 1310-1331 .- 2367-5535. ; 63:8, s. 1191-1200
  • Tidskriftsartikel (refereegranskat)abstract
    • The paper presents the results from planetary boundary layer (PBL) height and aerosol optical depth (AOD) measurements carried out in two different experimental sites in Sofia as well as from three-point measurements of aerosol number concentration.The main aim of the present investigation is to determine optical and microphysical characteristics of the atmospheric aerosol in three points of the valley and their variation during the PBL formation over urban area, park zone and mountain site. Four instruments (lidar, ceilometer, aerosol particle counter and sun photometer) were used in this study.The experimental AOD data obtained at lambda = 500nm gave values in the range from 0.22 to 0.41 in case of cloud-free skies and up to around 0.8 under partly cloudy conditions. Aerosol particle counter data on aerosol-particle concentration variations in the size range 0.3-1 mu m provided supportive information on the evolution of the valley-mountain aerosol in time and height during the mixing layer development. Joint interpretation of sun photometer, aerosol lidar and ceilometer CHM 15k data allow the influence of the main part of the atmospheric aerosol in the planetary boundary layer to be accounted as well as the significant influence of aerosol layers and high clouds on AOD values.
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  • Girnita, L., et al. (författare)
  • Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53 : Functional impact
  • 2000
  • Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 60:18, s. 5278-5283
  • Tidskriftsartikel (refereegranskat)abstract
    • We investigated the functional impact of p53 on insulin-like growth factor I receptor (IGF-IR) expression in malignant cells. Using the BL-41tsp53-2 cell line, a transfectant carrying temperature-sensitive (ts) p53 and endogenous mutant p53 (codon 248), we demonstrated a drastic down-regulation of plasma membrane-bound IGF-IRs on induction of wild-type p53, However, a similar response was obtained by treatment of BL-41tsp53-2 cells expressing mutant ts p53 with a p53 antisense oligonucleotide. Thus, even if the negative effect of wild-type p53 predominates under a competitive condition, these data indicate that mutant p53 may be important for up-regulation of IGF-IR, To further elucidate this issue, three melanoma cell lines (BE, SK-MEL-5, and SK-MEL-28) that over expressed p53 were investigated. The BE cell line has a hot spot mutation (codon 248) and expresses only codon 248-mutant p53, SK-MEL-28 has a point mutation at codon 145. SK-MEL-5 cells did not exhibit any p53 mutations, but the absence of p21(Waf1) expression suggested functionally aberrant p53. Our data suggest that interaction with Mdm-2 may underlie p53 inactivation in these cells, Using p53 antisense oligonucleotides, we demonstrated a substantial down-regulation of cell surface expression of IGF-IR proteins in all melanoma cell lines after 24 h, This was paralleled by decreased tyrosine phosphorylation of IGF-IR and growth arrest, and, subsequently, massive cell death was observed (this was also seen in BL-41tsp53-2 cells with mutant conformation of ts p53). Taken together, our results suggest that up-regulation of IGF-IR as a result of expression of aberrant p53 may be important for the growth and survival of malignant cells.
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