SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Winblad B) "

Sökning: WFRF:(Winblad B)

  • Resultat 21-30 av 990
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
21.
  •  
22.
  •  
23.
  • Ankarcrona, M., et al. (författare)
  • Current and future treatment of amyloid diseases
  • 2016
  • Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 280:2, s. 177-202
  • Forskningsöversikt (refereegranskat)abstract
    • There are more than 30 human proteins whose aggregation appears to cause degenerative maladies referred to as amyloid diseases or amyloidoses. These disorders are named after the characteristic cross--sheet amyloid fibrils that accumulate systemically or are localized to specific organs. In most cases, current treatment is limited to symptomatic approaches and thus disease-modifying therapies are needed. Alzheimer's disease is a neurodegenerative disorder with extracellular amyloid -peptide (A) fibrils and intracellular tau neurofibrillary tangles as pathological hallmarks. Numerous clinical trials have been conducted with passive and active immunotherapy, and small molecules to inhibit A formation and aggregation or to enhance A clearance; so far such clinical trials have been unsuccessful. Novel strategies are therefore required and here we will discuss the possibility of utilizing the chaperone BRICHOS to prevent A aggregation and toxicity. Type 2 diabetes mellitus is symptomatically treated with insulin. However, the underlying pathology is linked to the aggregation and progressive accumulation of islet amyloid polypeptide as fibrils and oligomers, which are cytotoxic. Several compounds have been shown to inhibit islet amyloid aggregation and cytotoxicity in vitro. Future animal studies and clinical trials have to be conducted to determine their efficacy in vivo. The transthyretin (TTR) amyloidoses are a group of systemic degenerative diseases compromising multiple organ systems, caused by TTR aggregation. Liver transplantation decreases the generation of misfolded TTR and improves the quality of life for a subgroup of this patient population. Compounds that stabilize the natively folded, nonamyloidogenic, tetrameric conformation of TTR have been developed and the drug tafamidis is available as a promising treatment. Read more articles from the symposium: Amyloid - a multifaceted player in human health and disease.
  •  
24.
  •  
25.
  •  
26.
  •  
27.
  • Besga, A., et al. (författare)
  • Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
  • 2012
  • Ingår i: Neuroscience Letters. - : Elsevier BV. - 0304-3940 .- 1872-7972. ; 510:2, s. 121-126
  • Tidskriftsartikel (refereegranskat)abstract
    • Investigate possible associations of white matter hyperintensities (WMHs) with the metabolism of cholesterol and insulin in two subgroups of patients with memory complaints and different CSF A beta 42 and CSF tau levels. 59 patients from the memory clinic at Karolinska Hospital were included. Degree of WMHs was rated using the ARWMC scale and the following biomarkers were measured in CSF and plasma: insulin, cholesterol, lanosterol, lathosterol, and oxidized cholesterol metabolites. The WMHs in CSF control-like group correlated with increased brain cholesterol synthesis and reduced efflux of oxysterols and insulin in CSF. In the CSF AD-like group, the WMHs correlated with increased peripheral cholesterol metabolism. Despite having similar appearance on FLAIR images, the pathogenic mechanisms of WMHS are likely to be different in the two groups investigated.
  •  
28.
  •  
29.
  •  
30.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 21-30 av 990
Typ av publikation
tidskriftsartikel (788)
konferensbidrag (185)
forskningsöversikt (9)
bokkapitel (3)
annan publikation (2)
bok (1)
visa fler...
proceedings (redaktörskap) (1)
recension (1)
visa färre...
Typ av innehåll
refereegranskat (732)
övrigt vetenskapligt/konstnärligt (258)
Författare/redaktör
Winblad, B (969)
Fratiglioni, L (127)
Viitanen, M (75)
Wimo, A (70)
BOGDANOVIC, N (63)
Cowburn, RF (56)
visa fler...
Fastbom, J (49)
Kivipelto, M (46)
Jelic, V (43)
Backman, L (42)
Pei, JJ (41)
Tjernberg, LO (38)
Cedazo-Minguez, A (36)
Wahlund, LO (35)
Soininen, H (35)
Eriksdotter, M (35)
Lannfelt, L (34)
Religa, D. (33)
Nordberg, A (32)
Zhu, J. (30)
Adem, A (30)
Qiu, CX (28)
Almkvist, O (28)
Ankarcrona, M (26)
Andreasen, N (25)
Jonsson, L. (24)
Graff, C (24)
Basun, H (24)
Garcia-Ptacek, S (24)
Naslund, J (23)
Forsell, Y (22)
Schultzberg, M (22)
Palmer, K (22)
Aarsland, D (21)
Wahlin, A (21)
Benedikz, E (21)
Johansson, G. (20)
Solomon, A (19)
ISLAM, A (18)
von Strauss, Eva (18)
Kareholt, I (18)
Iqbal, K (18)
Schedin-Weiss, S (18)
Kramberger, MG (17)
Aguero-Torres, H (17)
Blennow, Kaj, 1958 (16)
Mix, E (16)
An, WL (16)
Gauthier, S (16)
Lilius, L (16)
visa färre...
Lärosäte
Karolinska Institutet (929)
Uppsala universitet (41)
Göteborgs universitet (30)
Röda Korsets Högskola (24)
Lunds universitet (19)
Stockholms universitet (13)
visa fler...
Umeå universitet (11)
Linköpings universitet (8)
Marie Cederschiöld högskola (7)
Örebro universitet (5)
Jönköping University (5)
Luleå tekniska universitet (2)
Chalmers tekniska högskola (2)
Linnéuniversitetet (2)
Sveriges Lantbruksuniversitet (2)
Kungliga Tekniska Högskolan (1)
Högskolan i Halmstad (1)
RISE (1)
Högskolan Dalarna (1)
Blekinge Tekniska Högskola (1)
visa färre...
Språk
Engelska (985)
Svenska (4)
Tyska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (80)
Samhällsvetenskap (6)
Naturvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy