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Träfflista för sökning "WFRF:(Wolf D. H.) "

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  • Mishra, A, et al. (author)
  • Diminishing benefits of urban living for children and adolescents' growth and development
  • 2023
  • In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
  • Journal article (peer-reviewed)abstract
    • Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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  • Ramdas, S., et al. (author)
  • A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
  • 2022
  • In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 109:8, s. 1366-1387
  • Journal article (peer-reviewed)abstract
    • A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
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  • Result 21-30 of 524
Type of publication
journal article (489)
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other publication (3)
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peer-reviewed (499)
other academic/artistic (18)
pop. science, debate, etc. (1)
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Montaruli, T. (134)
Kappes, A. (132)
Karg, T. (132)
Aguilar, J. A. (130)
Madsen, J. (128)
De Clercq, C. (127)
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Zhang, Z. (126)
Hultqvist, K. (126)
Schmidt, T. (126)
Tilav, S. (126)
Kolanoski, H. (125)
Bai, X. (125)
Kowalski, M. (125)
Grant, D. (125)
Helbing, K. (125)
Hoffman, K. D. (125)
Hoshina, K. (125)
Ishihara, A. (125)
Karle, A. (125)
Kiryluk, J. (125)
Meagher, K. (125)
Naumann, U. (125)
Olivas, A. (125)
Rawlins, K. (125)
Resconi, E. (125)
Rhode, W. (125)
Rott, C. (125)
Ruhe, T. (125)
Ryckbosch, D. (125)
Stanev, T. (125)
Stezelberger, T. (125)
Taboada, I. (125)
van Santen, J. (125)
Wendt, C. (125)
Williams, D. R. (125)
Xu, X. W. (125)
Berley, D. (124)
Bernardini, E. (124)
Blaufuss, E. (124)
Desiati, P. (124)
Fazely, A. R. (124)
Gerhardt, L. (124)
Halzen, F. (124)
Hickford, S. (124)
Przybylski, G. T. (124)
Sarkar, S. (124)
Seckel, D. (124)
Seunarine, S. (124)
Spiering, C. (124)
Wiebusch, C. H. (124)
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Luleå University of Technology (1)
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Stockholm School of Economics (1)
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English (524)
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Natural sciences (347)
Medical and Health Sciences (93)
Social Sciences (8)
Engineering and Technology (6)
Agricultural Sciences (3)

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