| 1011. |
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| 1012. |
- Lumsden, A, et al.
(författare)
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Neurobiology.
- 2001
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Ingår i: Current Opinion in Neurobiology. - 0959-4388 .- 1873-6882. ; 11:3, s. 259-66
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Forskningsöversikt (refereegranskat)
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| 1013. |
- Lundgren, Markus, et al.
(författare)
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Analgesic antipyretic use among young children in the TEDDY study : No association with islet autoimmunity
- 2017
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Ingår i: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.
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| 1014. |
- Ly, Monica T, et al.
(författare)
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Association of Vascular Risk Factors and CSF and Imaging Biomarkers With White Matter Hyperintensities in Former American Football Players.
- 2024
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Ingår i: Neurology. - 1526-632X. ; 102:2
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Tidskriftsartikel (refereegranskat)abstract
- Recent data link exposure to repetitive head impacts (RHIs) from American football with increased white matter hyperintensity (WMH) burden. WMH might have unique characteristics in the context of RHI beyond vascular risk and normal aging processes. We evaluated biological correlates of WMH in former American football players, including markers of amyloid, tau, inflammation, axonal injury, neurodegeneration, and vascular health.Participants underwent clinical interviews, MRI, and lumbar puncture as part of the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy Research Project. Structural equation modeling tested direct and indirect effects between log-transformed total fluid-attenuated inversion recovery (FLAIR) lesion volumes (TLV) and the revised Framingham stroke risk profile (rFSRP), MRI-derived global metrics of cortical thickness and fractional anisotropy (FA), and CSF levels of amyloid β1-42, p-tau181, soluble triggering receptor expressed on myeloid cells 2 (sTREM2), and neurofilament light. Covariates included age, race, education, body mass index, APOE ε4 carrier status, and evaluation site. Models were performed separately for former football players and a control group of asymptomatic men unexposed to RHI.In 180 former football players (mean age = 57.2, 36% Black), higher log(TLV) had direct associations with the following: higher rFSRP score (B = 0.26, 95% CI 0.07-0.40), higher p-tau181 (B = 0.17, 95% CI 0.01-0.43), lower FA (B = -0.28, 95% CI -0.42 to -0.13), and reduced cortical thickness (B = -0.25, 95% CI -0.45 to -0.08). In 60 asymptomatic unexposed men (mean age = 59.3, 40% Black), there were no direct effects on log(TLV) (rFSRP: B = -0.03, 95% CI -0.48 to 0.57; p-tau181: B = -0.30, 95% CI -1.14 to 0.37; FA: B = -0.07, 95% CI -0.48 to 0.42; or cortical thickness: B = -0.28, 95% CI -0.64 to 0.10). The former football players showed stronger associations between log(TLV) and rFSRP (1,069% difference in estimates), p-tau181 (158%), and FA (287%) than the unexposed men.Risk factors and biological correlates of WMH differed between former American football players and asymptomatic unexposed men. In addition to vascular health, p-tau181 and diffusion tensor imaging indices of white matter integrity showed stronger associations with WMH in the former football players. FLAIR WMH may have specific risk factors and pathologic underpinnings in RHI-exposed individuals.
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| 1015. |
- Machiela, Mitchell J, et al.
(författare)
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Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.
- 2017
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 72:5, s. 747-754
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings.OBJECTIVE: We performed an analysis of genetic variants associated with leukocyte telomere length to assess the relationship between telomere length and RCC risk using Mendelian randomization, an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations.DESIGN, SETTING, AND PARTICIPANTS: Genotypes from nine telomere length-associated variants for 10 784 cases and 20 406 cancer-free controls from six genome-wide association studies (GWAS) of RCC were aggregated into a weighted genetic risk score (GRS) predictive of leukocyte telomere length.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Odds ratios (ORs) relating the GRS and RCC risk were computed in individual GWAS datasets and combined by meta-analysis.RESULTS AND LIMITATIONS: Longer genetically inferred telomere length was associated with an increased risk of RCC (OR=2.07 per predicted kilobase increase, 95% confidence interval [CI]:=1.70-2.53, p<0.0001). As a sensitivity analysis, we excluded two telomere length variants in linkage disequilibrium (R2>0.5) with GWAS-identified RCC risk variants (rs10936599 and rs9420907) from the telomere length GRS; despite this exclusion, a statistically significant association between the GRS and RCC risk persisted (OR=1.73, 95% CI=1.36-2.21, p<0.0001). Exploratory analyses for individual histologic subtypes suggested comparable associations with the telomere length GRS for clear cell (N=5573, OR=1.93, 95% CI=1.50-2.49, p<0.0001), papillary (N=573, OR=1.96, 95% CI=1.01-3.81, p=0.046), and chromophobe RCC (N=203, OR=2.37, 95% CI=0.78-7.17, p=0.13).CONCLUSIONS: Our investigation adds to the growing body of evidence indicating some aspect of longer telomere length is important for RCC risk.PATIENT SUMMARY: Telomeres are segments of DNA at chromosome ends that maintain chromosomal stability. Our study investigated the relationship between genetic variants associated with telomere length and renal cell carcinoma risk. We found evidence suggesting individuals with inherited predisposition to longer telomere length are at increased risk of developing renal cell carcinoma.
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| 1016. |
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| 1017. |
- Mason, Richard J., et al.
(författare)
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The zoogeomorphology of case-building caddisfly : Quantifying sediment use
- 2019
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Ingår i: Earth Surface Processes and Landforms. - : John Wiley & Sons. - 0197-9337 .- 1096-9837. ; 44:12, s. 2510-2525
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Tidskriftsartikel (refereegranskat)abstract
- Caddisfly (Trichoptera) larvae are an abundant and widespread aquatic insect group characterized by the construction of silk structures, including nets and cases. Case-building caddisfly have the potential to modify the sorting and mobility of sand and fine gravel via: (1) case construction, resulting in altered sediment properties; (2) transporting sediment incorporated into cases over the river bed; and (3) changing the structure of river beds via burrowing activity. To investigate these mechanisms, it is necessary to understand the mass, size distribution and spatial variability of sediment use by case-building caddisfly larvae. We quantified the mineral sediment used by individuals and communities of case-building caddisfly in 27 samples, from three sites on a gravel-bed stream. The mass and size distribution of sediment in individual cases varied between taxa (mass = 0.001-0.83 g, D-50 = 0.17-4 mm). The mean mass of sediment used by the caddisfly community was 38 g m(-2) and varied locally. Sediment use was predominantly coarse sand (D-50 = 1 mm). 64% of sediment use was attributable to Agapetus fuscipes (Glossosomatidae). Due to within-species variability in case mass, the abundance of most taxa, including A. fuscipes, was only weakly associated with the mass of sediment used by this species, at the river scale. Whilst the caddisfly community used a small percentage of the total sediment available (average 2.99% of the 1-1.4 mm size fraction), A. fuscipes used more fine sediment in their cases at sites where it was more available. Despite variability in local habitat, all sites supported diverse case-building caddisfly communities utilizing mineral sediment. Consequently, geomorphological effects of case-building caddisfly are potentially widespread. The results provide novel insights into the specific grain sizes and quantities of fine sediment used by caddisfly larvae, which represents an important step towards understanding their zoogeomorphic activities.
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| 1018. |
- Mason, Richard, et al.
(författare)
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Vertical reworking of sediment by the cased caddisfly Glossosomatidae (Agapetus fuscipes) increases sand exposure and availability in armoured gravel-bed rivers
- 2022
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Ingår i: Geomorphology. - : Elsevier. - 0169-555X .- 1872-695X. ; 418
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Tidskriftsartikel (refereegranskat)abstract
- Landscapes and ecosystems are the result of two-way interactions between hydro-geomorphic and biological processes. Many animals, particularly those that build structures or transport sediment, are important biogeomorphic agents. Glossosomatidae caddisfly larvae (Insecta, Trichoptera) are globally widespread and abundant inhabitants of gravel-bed rivers. Glossosomatidae build mobile cases from sand that they transport over the river bed. However, there is limited understanding on how Glossosomatidae bioconstructions may influence sand distribution in rivers or how their zoogeomorphic behaviours are influenced by hydraulics or characteristics of the river bed. First, we conducted surveys to quantify the magnitude of sand incorporated into Glossosomatidae (Agapetus fuscipes) cases within a UK river. Second, we studied A. fuscipes movement behaviour and quantified the direction and magnitude of sediment reworking, in a flume, under differing flow velocity and gravel size treatments. We found that 99 % of A. fuscipes larvae transported sediment vertically upwards. This resulted in an average conveyance per larvae of 0.06 g sand upwards by 25 mm (maximum of 50 mm). In gravel beds with a coarse surface layer, this resulted in displacement of sand from sheltered interstices onto the surface of exposed gravel particles. In the flume, this behaviour was maintained even at high flows, sufficient to entrain empty cases from these locations. Whilst the mass of sediment moved by individual larvae is small, dense populations of Glossosomatidae larvae may have important consequences for the vertical distribution of sand in rivers. At our field site, A. fuscipes case density averaged 2192 cases m- 2, equivalent to 1.4 t km-1. This finding is important because in gravel-bed rivers frequented by Glossosomatidae larvae, sediment transport is typically limited by the availability of entrainable fine grain sediment at the surface. We discuss the implications of this sediment movement for river bed sedimentary structure, the transport of sand and gravel, and the possible role of Glossosomatidae larvae as ecosystem engineers.
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| 1019. |
- McCarthy, Shane, et al.
(författare)
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A reference panel of 64,976 haplotypes for genotype imputation
- 2016
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:10, s. 1279-1283
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Tidskriftsartikel (refereegranskat)abstract
- We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.
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| 1020. |
- McCoy, Daniel T., et al.
(författare)
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Predicting decadal trends in cloud droplet number concentration using reanalysis and satellite data
- 2018
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Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 18:3, s. 2035-2047
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Tidskriftsartikel (refereegranskat)abstract
- Cloud droplet number concentration (CDNC) is the key state variable that moderates the relationship between aerosol and the radiative forcing arising from aerosolcloud interactions. Uncertainty related to the effect of anthropogenic aerosol on cloud properties represents the largest uncertainty in total anthropogenic radiative forcing. Here we show that regionally averaged time series of the Moderate-Resolution Imaging Spectroradiometer (MODIS) observed CDNC of low, liquid-topped clouds is well predicted by the MERRA2 reanalysis near-surface sulfate mass concentration over decadal timescales. A multiple linear regression between MERRA2 reanalyses masses of sulfate (SO4), black carbon (BC), organic carbon (OC), sea salt (SS), and dust (DU) shows that CDNC across many different regimes can be reproduced by a simple power-law fit to near-surface SO4, with smaller contributions from BC, OC, SS, and DU. This confirms previous work using a less sophisticated retrieval of CDNC on monthly timescales. The analysis is supported by an examination of remotely sensed sulfur dioxide (SO2) over maritime volcanoes and the east coasts of North America and Asia, revealing that maritime CDNC responds to changes in SO2 as observed by the ozone monitoring instrument (OMI). This investigation of aerosol reanalysis and top-down remote-sensing observations reveals that emission controls in Asia and North America have decreased CDNC in their maritime outflow on a decadal timescale.
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