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- Liu, Chuan S., et al.
(författare)
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Laser acceleration of quasi-monoenergetic protons via radiation pressure driven thin foil
- 2010
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Ingår i: Modern challenges in nonlinear plasma physics. - : AIP. - 9780735408753 ; , s. 104-110
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Konferensbidrag (refereegranskat)abstract
- We present a theoretical and simulation study of laser acceleration of quasi-monoenergetic protons in a thin foil irradiated by high intensity laser light. The underlying physics of radiation pressure acceleration (RPA) is discussed, including the importance of optimal thickness and circularly polarized light for efficient acceleration of ions to quasimonoenergetic beams. Preliminary two-dimensional simulation studies show that certain parameter regimes allow for stabilization of the Rayleigh-Taylor instability and possibility of acceleration of monoenergetic ions to an excess of 200MeV, making them suitable for important applications such as medical cancer therapy and fast ignition. © 2010 American Institute of Physics.
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| 27. |
- Mahajan, Anubha, et al.
(författare)
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- 2022
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:5, s. 560-572
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Tidskriftsartikel (refereegranskat)abstract
- We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
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| 30. |
- Tripathi, V. K., et al.
(författare)
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Laser acceleration of monoenergetic protons in a self-organized double layer from thin foil
- 2009
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 51, s. 024014-024022
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Tidskriftsartikel (refereegranskat)abstract
- We present a theory for the acceleration of monoenergetic protons, trapped in a self-organized double layer, by short pulse laser irradiation on a thin foil with the specific thickness suggested by the simulation study of Yan et al (2008 Phys. Rev. Lett. 100 135003). The laser ponderomotive force pushes the electrons forward, leaving the ions behind until the space charge electric field balances the ponderomotive force at a distance Δ. For the optimal target thickness D = Δ > c/ωp, the electron sheath is piled up at the rear surface and the sheath electric field accelerates the protons until they are reflected by the inertial force in the accelerated frame. These protons are therefore trapped by the combined forces of the electrostatic field of the electron sheath and the inertial force of the accelerating target. Together with the electron layer, they form a double layer and are collectively accelerated by the laser ponderomotive force, leading to monoenergetic ion production.
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