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Träfflista för sökning "WFRF:(Xu JF) "

Search: WFRF:(Xu JF)

  • Result 61-70 of 142
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  • Dadaev, T, et al. (author)
  • Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
  • 2018
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 2256-
  • Journal article (peer-reviewed)abstract
    • Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.
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  • De Marzo, AM, et al. (author)
  • Inflammation in prostate carcinogenesis
  • 2007
  • In: Nature reviews. Cancer. - : Springer Science and Business Media LLC. - 1474-175X .- 1474-1768. ; 7:4, s. 256-269
  • Journal article (peer-reviewed)
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  • Result 61-70 of 142
Type of publication
journal article (133)
conference paper (6)
research review (1)
Type of content
peer-reviewed (127)
other academic/artistic (13)
Author/Editor
Xu, JF (55)
Gronberg, H (46)
Isaacs, WB (36)
Brenner, H (26)
Zhang, Z. (24)
Jonas, JB (23)
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Zheng, SL (23)
Riboli, E. (21)
Li, Y. (20)
Silva, DAS (19)
Joshi, P. (19)
Schleutker, J (19)
Kim, J. (18)
Diaz, A. (18)
Farzadfar, F (18)
Kote-Jarai, Z (18)
Thibodeau, SN (18)
Stanford, JL (18)
Gupta, R. (17)
Khader, YS (17)
Khang, YH (17)
Shiri, R (17)
Lee, J. (17)
Maier, C (17)
Xu, L. (16)
Peters, A (16)
Kumar, P. (16)
Malekzadeh, R (16)
Pandey, A (16)
Sepanlou, SG (16)
Easton, DF (16)
Lehtimaki, T. (16)
He, J (16)
Hunter, DJ (16)
Khaw, KT (16)
Zhu, Y. (15)
Kumar, A. (15)
Mahajan, A. (15)
Khan, M (15)
Shibuya, K (15)
Topor-Madry, R (15)
SCHAID, DJ (15)
Giles, GG (15)
Ikram, MA (15)
Nordestgaard, BG (15)
Haiman, CA (15)
Le Marchand, L (15)
Chanock, SJ (15)
Berndt, SI (15)
Albanes, D (15)
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University
Karolinska Institutet (138)
Uppsala University (33)
Umeå University (19)
Lund University (19)
University of Gothenburg (16)
Högskolan Dalarna (13)
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Royal Institute of Technology (5)
University of Skövde (5)
Linköping University (2)
Chalmers University of Technology (2)
Stockholm University (1)
Jönköping University (1)
Stockholm School of Economics (1)
Södertörn University (1)
Swedish University of Agricultural Sciences (1)
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Language
English (142)
Research subject (UKÄ/SCB)
Medical and Health Sciences (48)
Natural sciences (7)
Social Sciences (2)

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