| 1561. |
- Kinyoki, DK, et al.
(författare)
-
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
- 2020
-
Ingår i: Nature medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 26:5, s. 750-759
-
Tidskriftsartikel (refereegranskat)abstract
- A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic.
|
|
| 1562. |
- Kootte, R. S., et al.
(författare)
-
Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
- 2017
-
Ingår i: Cell Metabolism. - : Elsevier BV. - 1550-4131. ; 26:4, s. 611-619
-
Tidskriftsartikel (refereegranskat)abstract
- The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as gamma-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.
|
|
| 1563. |
- Kraus, Stefan, et al.
(författare)
-
Planet Formation Imager (PFI) : Science vision and key requirements
- 2016
-
Ingår i: Optical and Infrared Interferometry and Imaging V. - : SPIE. - 9781510601932 ; 9907
-
Konferensbidrag (refereegranskat)abstract
- The Planet Formation Imager (PFI) project aims to provide a strong scientific vision for ground-based optical astronomy beyond the upcoming generation of Extremely Large Telescopes. We make the case that a breakthrough in angular resolution imaging capabilities is required in order to unravel the processes involved in planet formation. PFI will be optimised to provide a complete census of the protoplanet population at all stellocentric radii and over the age range from 0.1 to ∼100 Myr. Within this age period, planetary systems undergo dramatic changes and the final architecture of planetary systems is determined. Our goal is to study the planetary birth on the natural spatial scale where the material is assembled, which is the "Hill Sphere" of the forming planet, and to characterise the protoplanetary cores by measuring their masses and physical properties. Our science working group has investigated the observational characteristics of these young protoplanets as well as the migration mechanisms that might alter the system architecture. We simulated the imprints that the planets leave in the disk and study how PFI could revolutionise areas ranging from exoplanet to extragalactic science. In this contribution we outline the key science drivers of PFI and discuss the requirements that will guide the technology choices, the site selection, and potential science/technology tradeoffs.
|
|
| 1564. |
- Kuznetsova, T. V., et al.
(författare)
-
A photoelectron spectroscopy study of the electronic structure evolution in CuInSe2-related compounds at changing copper content
- 2012
-
Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 101:11, s. 111607-
-
Tidskriftsartikel (refereegranskat)abstract
- Evolution of the valence-band structure at gradually increasing copper content has been analysed by x-ray photoelectron spectroscopy (XPS) in In2Se3, CuIn5Se8, CuIn3Se5, and CuInSe2 single crystals. A comparison of these spectra with calculated total and angular-momentum resolved density-of-states (DOS) revealed the main trends of this evolution. The formation of the theoretically predicted gap between the bonding and non-bonding states has been observed in both experimental XPS spectra and theoretical DOS.
|
|
| 1565. |
- Ladds, Marcus J. G. W., et al.
(författare)
-
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
- 2018
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- The development of non-genotoxic therapies that activate wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor suppressor. Here we report the identification of over 100 small-molecules activating p53 in cells. We elucidate the mechanism of action of a chiral tetrahydroindazole (HZ00), and through target deconvolution, we deduce that its active enantiomer (R)-HZ00, inhibits dihydroorotate dehydrogenase (DHODH). The chiral specificity of HZ05, a more potent analog, is revealed by the crystal structure of the (R)-HZ05/DHODH complex. Twelve other DHODH inhibitor chemotypes are detailed among the p53 activators, which identifies DHODH as a frequent target for structurally diverse compounds. We observe that HZ compounds accumulate cancer cells in S-phase, increase p53 synthesis, and synergize with an inhibitor of p53 degradation to reduce tumor growth in vivo. We, therefore, propose a strategy to promote cancer cell killing by p53 instead of its reversible cell cycle arresting effect.
|
|
| 1566. |
|
|
| 1567. |
|
|
| 1568. |
- Lanzafame, A. C., et al.
(författare)
-
Gaia Data Release 3 : Stellar chromospheric activity and mass accretion from Ca II IRT observed by the Radial Velocity Spectrometer
- 2023
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 674
-
Tidskriftsartikel (refereegranskat)abstract
- Context: The Gaia Radial Velocity Spectrometer (RVS) provides the unique opportunity of a spectroscopic analysis of millions of stars at medium resolution (lambda/Delta lambda similar to 11 500) in the near-infrared (845 872 nm). This wavelength range includes the Ca ii infrared triplet (IRT) at 850.03, 854.44, and 866.45 nm, which is a good indicator of magnetic activity in the chromosphere of late-type stars.Aims: Here we present the method devised for inferring the Gaia stellar activity index from the analysis of the Ca ii IRT in the RVS spectrum, together with its scientific validation.Methods: The Gaia stellar activity index is derived from the Ca ii IRT excess equivalent width with respect to a reference spectrum, taking the projected rotational velocity (v sin i) into account. We performed scientific validation of the Gaia stellar activity index by deriving a R'(IRT) index, which is largely independent of the photospheric parameters, and considering the correlation with the R'(HK) index for a sample of stars. A sample of well-studied pre-main-sequence (PMS) stars is considered to identify the regime in which the Gaia stellar activity index may be a ffected by mass accretion. The position of these stars in the colour-magnitude diagram and the correlation with the amplitude of the photometric rotational modulation is also scrutinised.Results: Gaia DR3 contains a stellar activity index derived from the Ca ii IRT for some 2 x 10(6) stars in the Galaxy. This represents a `gold mine' for studies on stellar magnetic activity and mass accretion in the solar vicinity. Three regimes of the chromospheric stellar activity are identified, confirming suggestions made by previous authors based on much smaller R-HK(') datasets. The highest stellar activity regime is associated with PMS stars and RS CVn systems, in which activity is enhanced by tidal interaction. Some evidence of a bimodal distribution in main sequence (MS) stars with T-eff >= 5000K is also found, which defines the two other regimes, without a clear gap in between. Stars with 3500K. T-e ff <= 5000K are found to be either very active PMS stars or active MS stars with a unimodal distribution in chromospheric activity. A dramatic change in the activity distribution is found for T-e ff <= 3500 K, with a dominance of low activity stars close to the transition between partially- and fully convective stars and a rise in activity down into the fully convective regime.
|
|
| 1569. |
- Le Guyader, Loïc, et al.
(författare)
-
State-resolved ultrafast charge and spin dynamics in [Co/Pd] multilayers
- 2022
-
Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 120:3
-
Tidskriftsartikel (refereegranskat)abstract
- We use transient absorption spectroscopy with circularly polarized x rays to detect laser-excited hole states below the Fermi level and compare their dynamics with that of unoccupied states above the Fermi level in ferromagnetic [Co/Pd] multilayers. While below the Fermi level, an instantaneous and significantly stronger demagnetization is observed, above the Fermi level, the demagnetization is delayed by 35 ± 10 fs. This provides a direct visualization of how ultrafast demagnetization proceeds via initial spin-flip scattering of laser-excited holes to the subsequent formation of spin waves.
|
|
| 1570. |
- Le Rutte, Epke A., et al.
(författare)
-
A case for ongoing structural support to maximise infectious disease modelling efficiency for future public health emergencies: A modelling perspective
- 2024
-
Ingår i: Epidemics. - 1755-4365 .- 1878-0067. ; 46
-
Tidskriftsartikel (refereegranskat)abstract
- This short communication reflects upon the challenges and recommendations of multiple COVID-19 modelling and data analytic groups that provided quantitative evidence to support health policy discussions in Switzerland and Germany during the SARS-CoV-2 pandemic. Capacity strengthening outside infectious disease emergencies will be required to enable an environment for a timely, efficient, and data-driven response to support decisions during any future infectious disease emergency. This will require 1) a critical mass of trained experts who continuously advance state-of-the-art methodological tools, 2) the establishment of structural liaisons amongst scientists and decision-makers, and 3) the foundation and management of data-sharing frameworks.
|
|
