11911. |
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11912. |
- Minervini, Amanda, et al.
(författare)
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Introduction
- 2023
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Ingår i: ReFiguring Global Challenges. - : Brill Academic Publishers. - 9789004680425 ; , s. 1-10
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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11913. |
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11914. |
- Miranda-Vizuete, A, et al.
(författare)
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Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial thioredoxin reductase (TrxR2) gene
- 2002
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Ingår i: Molecules and Cells. - : Korean Society for Molecular Biology. - 1016-8478 .- 0219-1032. ; 13:3, s. 488-492
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Tidskriftsartikel (refereegranskat)abstract
- Eukaryotic mitochondria are equipped with a complete thioredoxin system, composed of thioredoxin and thioredoxin reductase, which has been implicated in the protection against the reactive oxygen intermediates generated during the respiratory process in this organelle. Like its cytosolic counterpart, mammalian mitochondrial thioredoxin reductase is a homodimeric selenoprotein. We report here the genomic organization of the mouse mitochondrial thioredoxin gene (TrxR2) that spans 53 kb and consists of 18 exons ranging from 20 to 210 bp. All splicing sites conformed to the GT/AG rule with the exon-intron boundaries located exactly at the same position as the human TrxR2 gene, the only mammalian mitochondrial thioredoxin reductase gene whose genomic structure has been elucidated to date. In addition, we have identified a novel mRNA splicing variant lacking intron 14 resulting in a protein subunit with a shorter interface domain This new splicing variant provides a frame work for further analysis of this important enzyme as its predicted homodimeric conformation can now be expanded to a putative heterodimeric structure as well as a small subunit homodimer with the obvious implications at the regulatory level.
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11915. |
- Miranda-Vizuete, Antonio, et al.
(författare)
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Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons
- 2006
-
Ingår i: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 580:2, s. 484-490
-
Tidskriftsartikel (refereegranskat)abstract
- Thioredoxins are a class of small proteins that play a key role in regulating many cellular redox processes. We report here the characterization of the first member of the thioredoxin family in metazoans that is mainly associated with neurons. The Caenorhabditis elegans gene B0228.5 encodes a thioredoxin (TRX-1) that is expressed in ASJ ciliated sensory neurons, and to some extent also in the posterior-most intestinal cells. TRX-1 is active at reducing protein disulfides in the presence of a heterologous thioredoxin reductase. A mutant worm strain carrying a null allele of the trx-1 gene displays a reproducible decrease in both mean and maximum lifespan when compared to wild-type. The identification and characterization of TRX-1 paves the way to use C elegans as an in vivo model to study the role of thioredoxins in lifespan and nervous system physiology and pathology.
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11916. |
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11917. |
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11918. |
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11919. |
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11920. |
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