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Sökning: db:Swepub > Nilsson Peter

  • Resultat 1131-1140 av 2013
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1131.
  • Nilsson, Peter (författare)
  • Biosensor technology applied to hybridization analysis and mutation detection
  • 1998
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This thesis demonstrates the application of biosensor technology for molecular biology investigations, utilizing a surface plasmon resonance based optical device for mass sensitive detection of biomolecular interactions at a chipsurface. Oligonucleotide model systems were designed for analysis of the action of DNA manipulating enzymes. DNA ligation, DNA cleavage and DNA synthesis could be quantitatively monitored in real-time. A protocol for DNA minisequencing was also established based on prevention of chain elongation by incorporation of chain-terminators. Determinations of affinities for short oligonucleotides hybridizing to an immobilized target were performed with various sequence content, length, temperature and degree of complementarity. The decrease in affinity for hybridizations involving mismatch situations was found to be strongly dependent on the relative position of the mismatch. Interestingly, also end-mismatches were clearly detectable. The stabilization effect achieved upon co-hybridization of two adjacently annealing short oligonucleotide modules (modular primer effect) was also investigated for different module combinations and hybridization situations. The modular concept of hybridizations was subsequently demonstrated to result in enhanced Capture of single stranded PCR products. The sequence based DNA analysis, first introduced with oligonucleotide modelsystems, was extended to the scanning and screening formutations in PCR amplified DNA from clinically relevant samples. Several different formats were investigated, eitherwith the PCR products immobilized on the chip and oligonucleotides injected or vice versa. Again, mismatch discrimination could be observed for wild type and mutant specific oligonucleotides hybridizing to the targets. The experimental set-up for mutation detection was further developed by the introduction of a subtractive mismatch sensitive hybridization outside the instrument and a subsequent determination of the relative amounts of remain ingoligonucleotides with analytical biosensor monitoring of hybridizations between fully complementary oligonucleotides. In conclusion, the applied technology was found to be a suitable tool for a wide range of molecular biology applications, with emphasis on hybridization analysis and mutation detection.
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1132.
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1133.
  • Nilsson, Peter, et al. (författare)
  • Blood pressure and pulse wave velocity as metrics for evaluating pathologic ageing of the cardiovascular system.
  • 2014
  • Ingår i: Blood Pressure. - : Informa UK Limited. - 0803-7051 .- 1651-1999. ; 23:1, s. 17-30
  • Forskningsöversikt (refereegranskat)abstract
    • The influence of chronological ageing on the components of the cardiovascular system is of fundamental importance for understanding how hemodynamics change and the cardiovascular risk increases with age, the most important risk marker. An increase in peripheral vascular resistance associated with increased stiffness of central elastic arteries represents hallmarks of this ageing effect on the vasculature, referred to as early vascular ageing (EVA). In clinical practice, it translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV) - a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is threshold for increased risk according. Improved lifestyle and control of risk factors via appropriate drug therapy are of importance in providing vascular protection related to EVA. One target group might be members of risk families including subjects with early onset cardiovascular disease.
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1134.
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1136.
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1138.
  • Nilsson, Peter (författare)
  • Butler's stone and ultimate psychological hedonism
  • 2013
  • Ingår i: Philosophia. - : Springer Science and Business Media LLC. - 0048-3893 .- 1574-9274. ; 41:2, s. 545-553
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper discusses psychological hedonism with special reference to the writings of Bishop Butler, and Elliott Sober and David Sloan Wilson. Contrary to philosophical orthodoxy, Sober and Wilson have argued that Butler failed to refute psychological hedonism. In this paper it is argued: (1) that there is a difference between reductive and ultimate psychological hedonism; (2) that Butler failed to refute ultimate psychological hedonism, but that he succeeded in refuting reductive psychological hedonism; and, finally and more importantly, (3) that Butler's criticism of reductive hedonism can be used as a stepping-stone in another argument showing the implausibility of ultimate psychological hedonism as well.
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Nilsson, Peter (1332)Ta bort avgränsningen
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