| 119071. |
- Wang, Chuan, et al.
(författare)
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Conceptual design of an integrated heating system at LKAB Malmberget with consideration of social-environmental damage costs
- 2010
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Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526 .- 1879-1786. ; 18:9, s. 944-951
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Tidskriftsartikel (refereegranskat)abstract
- LKAB Malmberget is a Swedish mining site located at Malmberget, Sweden. Seven boiler centers are located in the north part of Malmberget. There are no connections in between these boiler centers, meaning that it is a decentralized heating system. The heat generated is used to heat up buildings and for mine ventilation air mainly during the cold periods. The heat is mainly provided from electric and oil boilers. However, most boilers under use are over 20 years old, and it is time to retrofit the boiler system and infrastructure. The purpose of this work is to design and optimize the heating system by introducing an integrated concept to minimize the heat production cost. An optimization model based on the mixed integer linear programming (MILP) has been developed. Several technical options have been considered in a new centralized heating system. The optimization principle is based on two kinds of perspectives: current price and external costs. With consideration of environmental and health damage from society concerns point of view, instead of environmental taxes in the current price perspective, the monetary values of externalities due to pollutants such as CO2, NOx, SO2 and particulates emitted from the heating system are included. On the basis of data input and assumptions, modeling results indicate that a lower cost could be achieved when a waste heat recovery boiler is installed at the older pelletization plant to recover sensible heat from flue gas. This technical option is the best solution or at least contributes to the best solution in all optimization results. Including the externality cost is useful for making fair evaluation of the social-environmental impacts of the alternatives. © 2010 Elsevier Ltd. All rights reserved.
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| 119072. |
- Wang, CH, et al.
(författare)
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Consensus statement on standard of care for congenital muscular dystrophies
- 2010
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Ingår i: Journal of child neurology. - : SAGE Publications. - 1708-8283 .- 0883-0738. ; 25:12, s. 1559-1581
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Tidskriftsartikel (refereegranskat)abstract
- Congenital muscular dystrophies are a group of rare neuromuscular disorders with a wide spectrum of clinical phenotypes. Recent advances in understanding the molecular pathogenesis of congenital muscular dystrophy have enabled better diagnosis. However, medical care for patients with congenital muscular dystrophy remains very diverse. Advances in many areas of medical technology have not been adopted in clinical practice. The International Standard of Care Committee for Congenital Muscular Dystrophy was established to identify current care issues, review literature for evidence-based practice, and achieve consensus on care recommendations in 7 areas: diagnosis, neurology, pulmonology, orthopedics/rehabilitation, gastroenterology/ nutrition/speech/oral care, cardiology, and palliative care. To achieve consensus on the care recommendations, 2 separate online surveys were conducted to poll opinions from experts in the field and from congenital muscular dystrophy families. The final consensus was achieved in a 3-day workshop conducted in Brussels, Belgium, in November 2009. This consensus statement describes the care recommendations from this committee.
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| 119073. |
- Wang, Chao, et al.
(författare)
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Diversity-Multiplexing Tradeoff Analysis of Coded Multi-User Relay Networks
- 2011
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Ingår i: IEEE Transactions on Communications. - 0090-6778 .- 1558-0857. ; 59:7, s. 1995-2005
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Tidskriftsartikel (refereegranskat)abstract
- We study the impact of multiple access strategies on the diversity-multiplexing tradeoff (DMT) performance in wireless multi-user relay networks. The networks contain multiple independent sources, multiple half-duplex decode-and-forward (DF) relays, and one common destination. Instead of separately retransmitting each source message, the relays employ a class of spectrally efficient finite field network codes to assist the sources. It is shown that fully orthogonal or fully non-orthogonal transmission among sources/relays does not necessarily provide optimized DMT performance. We propose a novel transmission protocol that divides the sources and relays into individual clusters. The nodes within one cluster transmit non-orthogonally while the transmissions of different clusters span orthogonal channels. We provide the method to calculate the achievable DMT for each clustering strategy. The network DMT performance can thus be optimized by properly clustering the multiple sources and relays.
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| 119074. |
- Wang, Chao, et al.
(författare)
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Diversity-multiplexing tradeoff analysis of multi-source multi-relay coded networks
- 2010
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Ingår i: 2010 International Symposium on Information Theory and its Applications (ISITA). ; , s. 422-427
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Konferensbidrag (refereegranskat)abstract
- We study the impact of efficient network coding and multiple access techniques in a two-source two-relay one-destination wireless network through the diversity-multiplexing tradeoff (DMT) analysis. We compare the standard relaying protocol without network coding and the protocols using either a binary network coding (BNC) or an appropriately designed non-binary finite-field network coding (FFNC) at the relays. It is shown that the use of the non-binary FFNC strictly outperforms the other two protocols in terms of DMT. In addition, we propose a new transmission strategy based on the non-binary FFNC design and the non-orthogonal multiple access technique to further improve the DMT performance. Our results highlight the advantages of applying appropriate network coding in multi-source multi-relay networks.
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| 119075. |
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| 119076. |
- Wang, Cao, et al.
(författare)
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FEM analysis of the temperature and stress distribution in spark plasma sintering : Modelling and experimental validation
- 2010
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Ingår i: Computational materials science. - : Elsevier. - 0927-0256 .- 1879-0801. ; 49:2, s. 351-362
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Tidskriftsartikel (refereegranskat)abstract
- A fully thermal-electrical-mechanical coupled and dynamic finite element model (FEM) is implemented to analyze of the temperature and stress distribution in spark plasma sintering (SPS) process. The real densification behaviour is also integrated by the moving mesh technique. The simulation studies were conducted using COMSOL and a range of die sizes, heating rates and uniaxial stresses were considered. The further validation experiments are implemented to validate the simulation results. The detailed microstructure investigations generally demonstrate that the temperature and stress profile obtained in present model are correct. But further development of complicated models is still needed for more precise prediction of sintering condition and microstructure development in SPS.
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| 119077. |
- Wang, Chunlin, et al.
(författare)
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High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets
- 2010
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 107:4, s. 1518-1523
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Tidskriftsartikel (refereegranskat)abstract
- Developing T cells face a series of cell fate choices in the thymus and in the periphery. The role of the individual T cell receptor (TCR) in determining decisions of cell fate remains unresolved. The stochastic/selection model postulates that the initial fate of the cell is independent of TCR specificity, with survival dependent on additional TCR/coreceptor "rescue" signals. The "instructive" model holds that cell fate is initiated by the interaction of the TCR with a cognate peptide-MHC complex. T cells are then segregated on the basis of TCR specificity with the aid of critical coreceptors and signal modulators [Chan S, Correia-Neves M, Benoist C, Mathis (1998) Immunol Rev 165: 195-207]. The former would predict a random representation of individual TCR across divergent T cell lineages whereas the latter would predict minimal overlap between divergent T cell subsets. To address this issue, we have used high-throughput sequencing to evaluate the TCR distribution among key T cell developmental and effector subsets from a single donor. We found numerous examples of individual subsets sharing identical TCR sequence, supporting a model of a stochastic process of cell fate determination coupled with dynamic patterns of clonal expansion of T cells bearing the same TCR sequence among both CD4(+) and CD8+ populations.
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| 119078. |
- Wang, Chunliang, 1980-, et al.
(författare)
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Integrating automatic and interactive method for coronary artery segmentation : let PACS workstation think ahead
- 2010
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Ingår i: International Journal of Computer Assisted Radiology and Surgery. - : Springer Science and Business Media LLC. - 1861-6410 .- 1861-6429. ; 5:3, s. 275-285
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To provide an efficient method to extract useful information from the increasing amount of coronary CTA.Methods: A quantitative coronary CTA analysis tool was built on OsiriX, which integrates both fully automatic and interactive methods for coronary artery extraction. The computational power of an ordinary PC is exploited by running the non-supervised coronary artery segmentation and centerline tracking in the background as soon as the images are received. When the user opens the data, the software provides a real-time interactive analysis environment.Results: The average overlap between the centerline created in our software and the reference standard was 96.0%. The average distance between them was 0.38 mm. The automatic procedure runs for 3-5 min as a single-thread application in background. Interactive processing takes 3 min in average.Conclusion: In preliminary experiments, the software achieved higher efficiency than the former interactive method, and reasonable accuracy compared to manual vessel extraction.
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| 119079. |
- Wang, C. L., et al.
(författare)
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DNA phosphorothioation is widespread and quantized in bacterial genomes
- 2011
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 108, s. 2963-2968
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Tidskriftsartikel (refereegranskat)abstract
- Phosphorothioate (PT) modification of DNA, with sulfur replacing a nonbridging phosphate oxygen, was recently discovered as a product of the dnd genes found in bacteria and archaea. Given our limited understanding of the biological function of PT modifications, including sequence context, genomic frequencies, and relationships to the diversity of dnd gene clusters, we under-took a quantitative study of PT modifications in prokaryotic genomes using a liquid chromatography-coupled tandem quadrupole mass spectrometry approach. The results revealed a diversity of unique PT sequence contexts and three discrete genomic frequencies in a wide range of bacteria. Metagenomic analyses of PT modifications revealed unique ecological distributions, and a phylogenetic comparison of dnd genes and PT sequence contexts strongly supports the horizontal transfer of dnd genes. These results are consistent with the involvement of PT modifications in a type of restriction-modification system with wide distribution in prokaryotes.
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| 119080. |
- Wang, Chunliang, et al.
(författare)
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Level-set based vessel segmentation accelerated with periodic monotonic speed function
- 2011
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Ingår i: Medical Imaging 2011. - : SPIE - International Society for Optical Engineering. - 9780819485045 ; , s. 79621M-1-79621M-7
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Konferensbidrag (refereegranskat)abstract
- To accelerate level-set based abdominal aorta segmentation on CTA data, we propose a periodic monotonic speed function, which allows segments of the contour to expand within one period and to shrink in the next period, i.e., coherent propagation. This strategy avoids the contour’s local wiggling behavior which often occurs during the propagating when certain points move faster than the neighbors, as the curvature force will move them backwards even though the whole neighborhood will eventually move forwards. Using coherent propagation, these faster points will, instead, stay in their places waiting for their neighbors to catch up. A period ends when all the expanding/shrinking segments can no longer expand/shrink, which means that they have reached the border of the vessel or stopped by the curvature force. Coherent propagation also allows us to implement a modified narrow band level set algorithm that prevents the endless computation in points that have reached the vessel border. As these points’ expanding/shrinking trend changes just after several iterations, the computation in the remaining iterations of one period can focus on the actually growing parts. Finally, a new convergence detection method is used to permanently stop updating the local level set function when the 0-level set is stationary in a voxel for several periods. The segmentation stops naturally when all points on the contour are stationary. In our preliminary experiments, significant speedup (about 10 times) was achieved on 3D data with almost no loss of segmentation accuracy.
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