SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) "

Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin)

  • Resultat 100661-100670 av 139590
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
100661.
  • Dahlberg, Leif, et al. (författare)
  • A randomized, multicentre, double-blind, parallel-group study to assess the adverse event-related discontinuation rate with celecoxib and diclofenac in elderly patients with osteoarthritis.
  • 2009
  • Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 38, s. 133-143
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: To compare the adverse event (AE)-related discontinuation rate with celecoxib vs. diclofenac when given to reduce joint pain associated with knee or hip osteoarthritis (OA) in elderly patients. Methods: This was a double-blind, randomized, multicentre, parallel-group, 1-year comparison of celecoxib 200 mg once daily and diclofenac 50 mg twice daily in 925 patients with OA aged >/= 60 years. Study visits were at baseline and at 4, 13, 26, 39, and 52 weeks. At each visit, the Patient's and Physician's Global Assessment of Arthritis (PaGAA, PhGAA), the Patient's Assessment of Arthritis Pain - Visual Analogue Scale (PAAP-VAS), and AEs were assessed. A concomitant health economic analysis was conducted throughout. Results: The rate of study discontinuation due to AEs, laboratory abnormalities, and deaths was 27% for celecoxib and 31% for diclofenac (p = 0.22). The results of the arthritis/pain efficacy assessments were similar for celecoxib and diclofenac. Significantly fewer patients in the celecoxib group than the diclofenac group experienced cardiovascular/renal AEs (70/458 vs. 95/458, p = 0.039) or hepatic AEs (10/458 vs. 39/458, p<0.0001). Medication costs were higher for celecoxib than diclofenac but mean total treatment cost was slightly higher in the diclofenac group. Conclusion: Treatment with celecoxib 200 mg once daily and diclofenac 50 mg twice daily resulted in similar rates of AE-related study discontinuation in elderly patients with OA. Celecoxib and diclofenac demonstrated comparable efficacy in relieving the signs and symptoms of OA. However, the proportion of patients with cardiorenal and hepatic AEs was significantly lower in the celecoxib group than the diclofenac group.
  •  
100662.
  • Dahlberg, L., et al. (författare)
  • Authors' reply
  • 1995
  • Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967. ; 54:8, s. 685-685
  • Tidskriftsartikel (refereegranskat)
  •  
100663.
  •  
100664.
  •  
100665.
  •  
100666.
  • Dahlberg, Mari, et al. (författare)
  • Tarmterapi
  • 2019
  • Ingår i: Uro-tarmterapi. - Lund : Studentlitteratur AB. - 9789144122588 ; , s. 93-139
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
  •  
100667.
  • Dahlberg, Sofia, et al. (författare)
  • Detection of subclinical vitamin K deficiency in neurosurgery with PIVKA-II
  • 2017
  • Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - : Informa UK Limited. - 0036-5513 .- 1502-7686. ; 77:4, s. 267-274
  • Tidskriftsartikel (refereegranskat)abstract
    • Vitamin K is known for supporting the carboxylation of hepatic coagulation proteins. Levels of proteins induced by vitamin K absence for factor II (PIVKA-II) reflect hypocarboxylated prothrombin and can be used to detect subclinical vitamin K deficiency. The aim of this study was to determine the prevalence of perioperative subclinical vitamin K deficiency among neurosurgical patients using PIVKA-II and investigate the existence of any correlation to standard coagulation assays. Also, the antitumor effects of vitamin K were reviewed. Thirty-five patients undergoing brain tumor resection were included. Blood samples were drawn preoperatively, at the end of surgery and in the morning after surgery. In addition to PIVKA-II, factor II and the Owren and Quick prothrombin times were analyzed. Seventeen of 35 patients had elevated PIVKA-II levels before surgery, which continued to be above normal range postoperatively. Median PIVKA-II and Owren prothrombin time (PT-INR) were increased on the morning day 1 postoperatively compared to before surgery, whereas Quick end-stage prothrombin time (EPT) decreased and factor II was unaffected. Postoperative complications were connected to high PIVKA-II increases. Positive correlations between PIVKA-II and factor II and body mass index (BMI) were found. In conclusion, PIVKA-II was increased in many patients preoperatively and then increased by the morning following surgery. Standard coagulation assays were largely non-pathological. Correlations were demonstrated between PIVKA-II and factor II and BMI. The effect of perioperative treatment with different vitamin K supplements should be investigated in future studies, as well as clinical trials evaluating their antitumor effects.
  •  
100668.
  •  
100669.
  •  
100670.
  • Dahlberg, Sofia, et al. (författare)
  • The effect of vitamin K on prothrombin time in critically ill patients: an observational registry study.
  • 2021
  • Ingår i: Journal of Intensive Care. - : Springer Science and Business Media LLC. - 2052-0492. ; 1, s. 11-17
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Previous studies have indicated that vitamin K deficiency is common in non-bleeding critically ill patients with slightly prolonged prothrombin time-international normalized ratio (PT-INR). It has never been investigated thoroughly whether the administration of vitamin K to these patients could affect their PT-INR. Therefore, the aim of this registry study was to evaluate changes in PT-INR in response to vitamin K in critically ill patients with PT-INR in the range of 1.3–1.9. Methods Patients admitted to a mixed 9-bed general intensive care unit at a University Hospital, between 2013 and 2019 (n = 4541) with a PT-INR between 1.3 and 1.9 at any time during the stay were identified. Patients who received vitamin K with appropriate sampling times for PT-INR and without exclusion criteria were matched with propensity score to patients from the same cohort who did not receive vitamin K (controls). PT-INR was measured at admission, within 12 h before vitamin K administration and 12–36 h following vitamin K administration. Exclusion criteria included pre-existing liver cirrhosis, any plasma or platelet transfusion, or > 1 unit red blood cell transfusion between PT-INR samplings. Results Propensity score matching resulted in two groups of patients with 129 patients in each group. PT-INR decreased in both groups (1.4 [1.3–1.4] in the vitamin K group and 1.4 [1.3–1.6] in the controls, p < 0.001 and p = 0.004, respectively). The decrease in PT-INR was slightly more pronounced in patients who received vitamin K (delta PT-INR − 0.10 [− 0.30 to − 0.10] in the vitamin K group and − 0.10 [− 0.20 to 0.10] in the controls, p = 0.01). Conclusion In critically ill patients with a PT-INR of 1.3–1.9, the administration of vitamin K resulted in a slightly larger decrease of PT-INR 12–36 h after administration compared to controls. Future studies should focus on identifying which patient populations may benefit most from vitamin K administration as well as whether vitamin K could be a better alternative than plasma or prothrombin complex concentrate to improve PT-INR before non-emergent invasive procedures.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 100661-100670 av 139590
Typ av publikation
tidskriftsartikel (114347)
konferensbidrag (6859)
doktorsavhandling (6554)
forskningsöversikt (6141)
bokkapitel (2704)
annan publikation (1792)
visa fler...
rapport (459)
bok (311)
samlingsverk (redaktörskap) (140)
licentiatavhandling (116)
recension (72)
patent (57)
proceedings (redaktörskap) (37)
konstnärligt arbete (13)
visa färre...
Typ av innehåll
refereegranskat (117246)
övrigt vetenskapligt/konstnärligt (21566)
populärvet., debatt m.m. (756)
Författare/redaktör
Zetterberg, Henrik, ... (793)
Blennow, Kaj, 1958 (745)
Melander, Olle (650)
Larsson, Anders (619)
Gillberg, Christophe ... (619)
Sundquist, Kristina (597)
visa fler...
Sundquist, Jan (595)
Nilsson, Peter (580)
Groop, Leif (575)
Lundälv, Jörgen, 196 ... (570)
Janson, Christer (519)
Ohlsson, Claes, 1965 (513)
Larsson, Henrik, 197 ... (501)
Engström, Gunnar (472)
Lind, Lars (465)
Hansson, Oskar (458)
Riboli, Elio (451)
Tumino, Rosario (439)
Erlinge, David (432)
Overvad, Kim (414)
Kaaks, Rudolf (406)
Swedberg, Karl, 1944 (400)
Olsson, Håkan (399)
Rosengren, Annika, 1 ... (398)
Stattin, Pär (394)
Ludvigsson, Jonas F. ... (392)
Trichopoulou, Antoni ... (391)
Boeing, Heiner (390)
Wennergren, Göran, 1 ... (389)
Karlsson, Jón, 1953 (379)
Bruze, Magnus (373)
Andersson, Roland (368)
Stibrant Sunnerhagen ... (357)
Khaw, Kay-Tee (343)
Wolk, Alicja (342)
Simrén, Magnus, 1966 (336)
Weiderpass, Elisabet ... (336)
Forssell-Aronsson, E ... (334)
Palli, Domenico (333)
Herlitz, Johan, 1949 (331)
Hemminki, Kari (325)
Lichtenstein, Paul (324)
Glimelius, Bengt (323)
Jirström, Karin (315)
Norrving, Bo (312)
Borg, Åke (310)
Lernmark, Åke (306)
Manjer, Jonas (304)
Giwercman, Aleksande ... (304)
Jacobsson, Bo, 1960 (299)
visa färre...
Lärosäte
Lunds universitet (47555)
Göteborgs universitet (36536)
Uppsala universitet (27510)
Karolinska Institutet (26306)
Umeå universitet (16663)
Linköpings universitet (11832)
visa fler...
Örebro universitet (9591)
Malmö universitet (3421)
Stockholms universitet (2873)
Kungliga Tekniska Högskolan (2429)
Chalmers tekniska högskola (2059)
Jönköping University (1726)
Linnéuniversitetet (1172)
Högskolan Dalarna (1028)
Högskolan i Skövde (789)
Sveriges Lantbruksuniversitet (760)
Högskolan i Halmstad (716)
Mittuniversitetet (647)
Högskolan i Borås (610)
Högskolan Kristianstad (550)
Karlstads universitet (508)
Mälardalens universitet (504)
Sophiahemmet Högskola (437)
Luleå tekniska universitet (393)
Gymnastik- och idrottshögskolan (365)
Högskolan Väst (306)
Högskolan i Gävle (304)
Marie Cederschiöld högskola (292)
Röda Korsets Högskola (235)
Blekinge Tekniska Högskola (216)
RISE (190)
Södertörns högskola (130)
Handelshögskolan i Stockholm (98)
VTI - Statens väg- och transportforskningsinstitut (58)
Försvarshögskolan (12)
Naturhistoriska riksmuseet (9)
Konstfack (4)
IVL Svenska Miljöinstitutet (4)
Stockholms konstnärliga högskola (3)
Kungl. Musikhögskolan (3)
Nordiska Afrikainstitutet (2)
visa färre...
Språk
Engelska (133564)
Svenska (5489)
Tyska (154)
Danska (50)
Spanska (44)
Franska (38)
visa fler...
Norska (38)
Odefinierat språk (36)
Finska (35)
Ungerska (31)
Portugisiska (22)
Isländska (17)
Italienska (14)
Kinesiska (11)
Ryska (9)
Japanska (9)
Polska (6)
Tjeckiska (6)
Nederländska (5)
Nygrekiska (3)
Esperanto (2)
Bosniska (2)
Grekiska, klassisk (1)
Estniska (1)
Rumänska (1)
Ukrainska (1)
visa färre...
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (139576)
Samhällsvetenskap (3765)
Naturvetenskap (3377)
Teknik (1590)
Humaniora (587)
Lantbruksvetenskap (363)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy