| 21. |
- Hedlin, Gunilla, et al.
(författare)
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Astma
- 1992
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Ingår i: Allergi och astma hos barn. - Lund : Draco Läkemedel AB. - 9186058320
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Bokkapitel (refereegranskat)
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| 22. |
- Jerkeman, Mats, et al.
(författare)
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Bacteremic and non-bacteremic febrile urinary tract infection--a review of 168 hospital-treated patients
- 1992
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Ingår i: Infection. - 1439-0973. ; 20:3, s. 143-145
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Tidskriftsartikel (refereegranskat)abstract
- Patients with febrile urinary tract infections with (80 patients) or without (88 patients) positive blood cultures were reviewed. Eighty-nine percent of the infections were community acquired. The bacteremic patients were older, Escherichia coli was the most commonly found organism in both groups. The most important finding in this study was increased frequency of resistance to three common urinary tract antibiotics (ampicillin, cephalothin and trimethoprim-sulfamethoxazole) in E. coli from patients with non-bacteremic compared with bacteremic infections. Complications occurred in 28 bacteremic and in three non-bacteremic patients. Six patients died, all with bacteremia. The significantly higher temperature at admittance among patients with gram-negative versus gram-positive bacteremic infection possibly reflects an effect by endotoxin.
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| 23. |
- Jonsson, B, et al.
(författare)
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Differences in fracture pattern between an urban and a rural population: a comparative population-based study in southern Sweden
- 1992
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Ingår i: Osteoporosis International. - 1433-2965. ; 2:6, s. 269-273
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Tidskriftsartikel (refereegranskat)abstract
- Differences in the incidence of hip fractures have been reported between urban and rural areas. In this population-based study the characteristics of fracture patterns between the city of Malmo and the nearby rural district of Sjobo were compared. A total of 782 individuals in Malmo and 486 in Sjobo were invited to participate. Fracture history for all invited was registered. The odds ratio for fracture was higher in Malmo, particularly for women over 70. More than half of the urban women aged 70 had a history of a fracture. A fourfold increase in fracture prevalence between the ages of 60 and 70 was observed in women in Malmo, whereas the prevalence doubled in Sjobo. The differences in fracture patterns between these two urban and rural communities may be explained by different lifestyles.
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| 24. |
- Karlsson, Magnus, et al.
(författare)
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Foreign body reaction after modified silicone rubber arthroplasty of the first carpometacarpal joint
- 1992
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Ingår i: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. - : Informa UK Limited. - 1651-2073 .- 0284-4311. ; 26:1, s. 101-103
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Tidskriftsartikel (refereegranskat)abstract
- Twenty patients who had been treated with a silicone rubber trapezial implant for degenerative changes in the first carpometacarpal joint were evaluated radiologically and clinically. After a mean follow up of 4.5 years, 11 of the 20 required reoperation and removal of the prosthesis for persisting pain and weakness. In all hands in which the prosthesis remained radiographs showed bone resorption or carpal bone cysts typical of silicone particle synovitis. In the light of these results we now do not recommend this procedure for the treatment of arthritis of the first carpometacarpal joint.
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| 25. |
- Karlsson, Roger, 1944-
(författare)
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Interference with biological rhythm : a novel approach to metabolic disorders in women
- 1992
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Women seem to be largely protected against certain ‘welfare disorders’ such as cardiovacular disease and osteoporosis, during their fertile years.The metabolic changes observed during women’s non-menstrual states, i.e. during pregnancy, after the menopause and during use of oral contraceptives, indicate the importance of sex steroids and an undisturbed biological rhythm. Treatment with monophasic, combined oral contraceptives constitutes a model for the non-cyclic state.Growth hormone (GH) is a pituitary hormone that has major metabolic effects. The pattern of GH exposure to the target organ is of vital importance for the effects and changes in rhythm could possibly induce metabolic changes.Growth hormome, cholecystokinin (CCK), osteocalcin and angiotensinogen were used as markers for metabolic effects and the concentrations in serum were recorded in women during non-menstrual states. The clinical material comprised a total of 60 women: 18 healthy non-pregnant, 25 pregnant, one lactating woman and 16 postmenopausal women. Using a portable pump and a non-thrombogenic venous catheter, blood samples could be collected at 30-min intervals during 24-h periods. Furthermore, the effects of estrogen and GH in the regulation of angiotensinogen were investigated in an experimental model in the rat.Oral contraceptives were found to alter the secretion of GH towards a pattern of lower and more frequent peaks, though the total amount secreted during 24 h was unchanged. Oral contraceptives seem to induce a suppression of the 24-h concentrations of CCK, which may be important with respect to weight gain in some women. Osteocalcin in serum display a significant circadian variation. This emphasizes the need for careful timing of single point measurements and the value of continuous blood sampling. Oral contraceptives may reduce osteocalcin serum concentrations. The long-term effects on bone are unknown. During late pregnancy osteocalcin levels are extremely low, which could indicate osteoblast inhibition and reduced bone turnover. The mode of GH administration is important for the plasma concentration of angiotensinogen in the non-pregnant rat. Estrogen effects on this protein may be mediated via a modification of GH secretion. Oral contraceptives not only increase angiotensinogen concentrations in serum but also markedly enhance their variability. Further studies are needed to elucidate the relation between the individual pattern of angiotensinogen and hypertension.
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| 26. |
- Kopp, Svenny, 1948, et al.
(författare)
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Girls with social deficits and learning problems: Autism, atypical Asperger syndrome or a variant of these conditions
- 1992
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Ingår i: European Child and Adolescent Psychiatry. - 1018-8827 .- 1435-165X. ; 1:2, s. 89-99
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Tidskriftsartikel (refereegranskat)abstract
- Six girls aged 6--10 years meeting criteria for autistic disorder are presented. They were all high-functioning in that they had IQs ha the 60-100 range and spoke in complicated sentences. Their clinical picture had not led a variety of specialists to consider an autism diagnosis before age 6 years in spite of the fact that they had shown mild motor delays, uncharacteristic developmental deviance and social, communicative and imaginative deficits already before age 2 years in all cases. It is suggested that the autism phenotype might be different in girls as compared with boys. It is further speculated that if female cases such as those described - and others given a whole host of different diagnostic labels - were only considered for an autism diagnosis, the high male:female ratio traditionally encountered in autism might drop considerably.
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| 27. |
- Mörgelin, Matthias, et al.
(författare)
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Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure
- 1992
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Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 267:9, s. 6137-6141
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Tidskriftsartikel (refereegranskat)abstract
- Cartilage oligomeric matrix protein was isolated in the native state from the Swarm rat chondrosarcoma. A crucial step was its selective extraction with EDTA-containing buffer. The purified protein was subjected to electron microscopy using rotary shadowing and negative stain. The images allowed the construction of a structural model. The bouquet-like protein consists of five 28-nm-long arms containing a peripheral globular domain, a flexible strand, and a central assembly domain, where the five arms meet in a cylindrical structure.
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| 28. |
- Mörgelin, Matthias, et al.
(författare)
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Proteoglycans from the swarm rat chondrosarcoma. Structure of the aggregates extracted with associative and dissociative solvents as revealed by electron microscopy
- 1992
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Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 267:20, s. 14275-14284
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Tidskriftsartikel (refereegranskat)abstract
- Proteoglycan aggregates were extracted from Swarm rat chondrosarcoma tissue in the native state and compared with proteoglycan aggregates isolated dissociatively with 4 M guanidine HCl. Purified aggregates were examined with a variety of electron microscopic techniques. In some cases they showed a structure of the central filament identical to that of the link-stabilized central filament observed in earlier experiments where the separated constituents were allowed to reconstitute (Morgelin, M., Paulsson, M., Hardingham, T. E., Heinegard, D., and Engel, J. (1988) Biochem. J. 253, 175-185). The tight packing of proteoglycan monomers along the hyaluronate with a minimum distance of 12 nm between adjacent E1 strands also could thus be confirmed for never dissociated aggregates. The results therefore show that the organization of proteoglycan aggregates assembled in vitro from the participating molecules is representative for conditions in situ. An additional structural type of central filament was observed in the preparations. This contained long stretches of free hyaluronate interspaced by short stretches of central filament with condensed arrays of link protein-proteoglycan. Chemical cross-linking in combination with low shear electron microscopical techniques showed that this discontinuous central filament structure is not an artifact of specimen preparation. The addition of suprastoichiometric amounts of exogenous link protein did not affect the central filament structure with the low packing density. Densely and loosely packed types of central filament were isolated in varying relative amounts with different associative and dissociative solvents.
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| 29. |
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| 30. |
- Nilsson, Ola, 1957, et al.
(författare)
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Presence of IGF-I in human midgut carcinoid tumours--an autocrine regulator of carcinoid tumour growth?
- 1992
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Ingår i: International journal of cancer. Journal international du cancer. - 0020-7136. ; 51:2, s. 195-203
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Tidskriftsartikel (refereegranskat)abstract
- The presence of IGF-I and IGF-I receptors in human midgut carcinoid tumours has been investigated. Using immunocytochemistry, IGF-I-positive tumour cells were demonstrated in 11/11 tumour cases studied. Labelling of consecutive sections with antibodies against IGF-I and proliferating cell nuclear antigen (PCNA)/cyclin demonstrated a co-distribution of the 2 antigens in carcinoid tumours. Extracts of tumour tissues were subjected to radioimmunoassay and shown to contain significant amounts of IGF-I. Reverse-phase HPLC of tumour extracts demonstrated a major IGF-I-immunoreactive component eluting in the position of rhIGF-I, but also 2 other more hydrophobic forms. Conditioned serum-free media from primary cultures of carcinoid tumors contained detectable amounts of IGF-I, indicating a spontaneous release of IGF-I from tumour cells into the culture medium. Levels of IGF-I in media were reduced (19%) after incubation of cultures with a somatostatin analogue for 4 days. IGF-I receptors were observed on tumour cells in 4/10 tumours by immunocytochemistry. Tumour cells with immunoreactive IGF-I receptors could be stimulated to enhanced growth, measured as an increase in DNA contents, by exogenous administration of IGF-I every 3-4 days for 2 weeks. The results show that cultured human midgut carcinoid tumours secrete IGF-I and that some of the tumours also have IGF-I receptors. We therefore suggest that IGF-I may act as an autocrine or paracrine regulator of carcinoid tumour-cell growth.
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