| 41. |
|
|
| 42. |
- Finizia, Caterina, 1961, et al.
(författare)
-
Advanced laryngeal cancer T3-T4 in Sweden: a retrospective study 1986-1990. Survival and locoregional control related to treatment.
- 1996
-
Ingår i: Acta oto-laryngologica. - : Informa UK Limited. - 0001-6489 .- 1651-2251. ; 116:6, s. 906-12
-
Tidskriftsartikel (refereegranskat)abstract
- Different treatment modalities for advanced laryngeal cancer are much discussed in the literature. One-hundred-and-sixty patients with T3-4, N0-3, M0-1 laryngeal cancer diagnosed in Sweden between 1986 and 1990 were retrospectively analysed. One hundred (65 T3: 35 T4) received radical radiotherapy with salvage surgery (RRSS) in case of residual or recurrent disease. Thirty-eight (11T3: 27 T4) patients received surgery with or without radiotherapy (S +/- RT). Twenty-two patients received no treatment. After a median follow up of 4.4 years, the estimated 5-year actuarial corrected survival and 3-year locoregional control were 59% and 44% for T3 RRSS and 47% and 54% for T3 S +/- RT. No significant difference between the different treatment modalities was found. The 5-year corrected survival rate and the locoregional control at 3 years between T4-RRSS (32%; 26%) and T4-S + RT (58%; 68%) groups were significantly different (p < 0.05 and p < 0.01). This might suggest that surgery with or without radiotherapy still has its place as a treatment modality for patients with advanced T4 laryngeal carcinoma.
|
|
| 43. |
- Ahlman, Håkan, 1947, et al.
(författare)
-
Neuroendocrine insights from the laboratory to the clinic.
- 1996
-
Ingår i: American journal of surgery. - 0002-9610. ; 172:1, s. 61-7
-
Tidskriftsartikel (refereegranskat)abstract
- The interaction between adrenergic nerves and enterochromaffin (EC) cells was studied in health and disease using animal models and patients with the midgut carcinoid syndrome.
|
|
| 44. |
- Axelsson, L., et al.
(författare)
-
Study of the unbound nucleus 11N by elastic resonance scattering
- 1996
-
Ingår i: Physical Review C (Nuclear Physics). - 0556-2813 .- 2469-9985 .- 2469-9993. ; 54:4, s. 1511-1514
-
Tidskriftsartikel (refereegranskat)abstract
- Resonances in the unbound nucleus 11N have been studied, using the resonance scattering reaction 10C+p. The data give evidence for three states above the 10C+p threshold with energies 1.30, 2.04, and 3.72 MeV. These states can be interpreted, in a potential-model analysis, as the ground state and the first two excited states with spin-parity 1 / 2+, 1 / 2-, and 5 / 2+ arising from the shell-model orbitals 1s1 / 2, 0p1 / 2, and 0d5 / 2. A narrow state superposed on a broad structure found at higher energy could be interpreted as the mirror state of the 3 / 2- in 11Be shifted down in energy. This shift would suggest a large radius of the potential.
|
|
| 45. |
- Bergenfelz, A, et al.
(författare)
-
Persistent elevated serum levels of intact parathyroid hormone after operation for sporadic parathyroid adenoma : evidence of detrimental effects of severe parathyroid disease
- 1996
-
Ingår i: Surgery. - 0039-6060. ; 119:6, s. 33-624
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A significant number of patients with primary hyperparathyroidism (pHPT) who are surgically treated have increased serum levels of intact parathyroid hormone (PTH) during long-term follow-up despite normocalcemia. The cause and significance of this finding remain to be established.METHODS: A total of 82 patients operated on for sporadic parathyroid adenoma were investigated before and at 8 weeks and 1 year after operation with serum levels of intact PTH, bone mineral content, and biochemical variables known to reflect PTH activity.RESULTS: All patients had low or normal serum levels of calcium during follow-up. At 8 weeks after operation 20 (24%) patients had increased serum levels of PTH. These patients had severe parathyroid disease and low levels of 25(OH) vitamin D before operation. In contrast to patients with normal levels of PTH after operation, they did not have an elevated bone mineral content but had elevated levels of serum creatinin. At 1 year after operation 13 patients had elevated serum levels of PTH. Compared with patients with normal serum levels of PTH, they were older and had an increased frequency of cardiovascular disease and biochemical indications of compromised renal function. They did not have an elevated bone mineral content.CONCLUSIONS: Persistently increased serum levels of PTH indicate harmful effects of pHPT even after surgical cure, especially in elderly patients with severe disease before operation. The results in this investigation therefore favor early treatment of pHPT.
|
|
| 46. |
- Bergenfelz, A, et al.
(författare)
-
Side localization of parathyroid adenomas by simplified intraoperative venous sampling for parathyroid hormone
- 1996
-
Ingår i: World Journal of Surgery. - : Springer Science and Business Media LLC. - 0364-2313 .- 1432-2323. ; 20:3, s. 60-358
-
Tidskriftsartikel (refereegranskat)abstract
- Side localization of parathyroid adenomas was performed by venous sampling for intact parathyroid hormone (PTH) in 20 consecutive patients with primary hyperparathyroidism (pHPT) after induction of anesthesia. The results were thus available during surgery. Nineteen of the patients had solitary parathyroid adenoma, and one had hyperplasia. There was no complication to the procedure. A lateralizing PTH gradient for a parathyroid adenoma was obtained in 13 patients. At surgery 12 of them (92%) were proved correct; that is, the adenoma was localized on the same side. Thus the technique correctly lateralized the adenoma in 12 of 19 patients (63%). We therefore conclude that the method of intraoperative venous sampling for intact PTH is safe, and the predictive value of a lateralizing gradient is high. It could therefore be used as an adjunct to surgical skill and noninvasive localization procedures in selected cases, for instance in patients with prior neck surgery and hypercalcemic crisis.
|
|
| 47. |
- Borssén, Bengt, 1946-
(författare)
-
Foot lesions in diabetic patients aged 15-20 years : a population-based study
- 1996
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Foot problems are not only the most common but in general also the most severe of the diabetic complications. The age group 15-50 yrs in this study was chosen because these patients were considered to be at their most active age and were felt to require optimal foot function.380 patients (96 %) participated, 78 % with Type 1, 20 % Type 2 and 1 % with secondary diabetes mellitus (DM) and 100 healthy controls. Only six patients had signs of peripheral ischaemia but half of the patients had deformities such as fallen forefoot arches and hammer toes. With sensory thresholds and clinical signs it was demonstrated that age, duration of DM and tall stature are major risk factors for diabetic neuropathy. Gender differences depend on differences in height. Dorsiflexion of the toes against resistance was used to test the function and volume of m.extensor digitorum brevis. When compared with measurements of sensory thresholds for vibration, perception and pain, it was found to be a valuable test for screening of distal motor neuropathy.To prevent worsening of foot deformities 266 patients with Type 1 DM were followed for 3 years. Those with the most pronounced deformities were fitted with custom-made insoles and had repeated examinations. Improvement was more common in patients with insoles compared to patients without insoles.Bone mineral density (BMD) was measured in nine patients with osteopathy in their feet and 18 controls. BMD was lower in L2-L3, but not in the proximal femur, implying osteopenia being a possible risk factor for distal osteopathy.Plaster cast treatment was used in 33 diabetic patients with severe foot ulcers who were selected because previous conservative treatment had been unsuccessful and they had been judged unsuitable for vascular surgery. The lesions healed in 19 patients.In conclusion, the main findings demonstrate the need for an increased awareness of early preventive foot care in young and middle-aged diabetic patients.
|
|
| 48. |
- Elmståhl, S., et al.
(författare)
-
The Malmö food study : The reproducibility of a novel diet history method and an extensive food frequency questionnaire
- 1996
-
Ingår i: European Journal of Clinical Nutrition. - 0954-3007. ; 50:3, s. 134-142
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To assess the reproducibility of two diet assessment methods, an extensive quantitative food frequency questionnaire (method A) and a novel shorter quantitative food frequency questionnaire with a 14 day food record (method B). Design: A randomized prospective cohort study. Setting: General community. Subjects: 241 residents of the town of Malmö, aged between 50-69 years, 126 men and 115 women who completed the methods one year apart. Methods: Both diet methods were designed to cover the whole diet and portion sizes were estimated using a booklet with 120 photographs; method A comprised 250 items and method B combined a two-week food record measuring lunch and dinner meals and a shorter 130 item quantitative food frequency questionnaire for average consumption of foods, snacks and beverages during the past year; Results: The percent difference between estimated energy intake one year apart were for men 10.7% for method A and 0.2% for method B, corresponding values for women 13.7% and 1.1%. Method B showed a good agreement between measurements for energy-providing nutrients, micronutrients and major food groups, i.e. meat products, edible fats, milk, fish, fruits and vegetables with correlation coefficients between 0.70-0.90 for women. The percent difference of average intake of edible fat was about 10%. Average energy-adjusted Pearson's correlation coefficients were of the order of 0.50-0.80 for most nutrients including 14 fatty acids. The correlation for the ratio between polyunsaturated and saturated fatty acids were about 0.70 for men and 0.80 for women; Conclusion: A modified diet history method combining a food record and a food frequency questionnaire shows good reproducibiiity. Sponsorship: This study was granted by the Swedish Medical research Council (Grant K 84-19X-7010-1) and by the International Agency for Research on cancer (Collaborative research agreement DEB/85/43).
|
|
| 49. |
|
|
| 50. |
|
|
