| 224421. |
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| 224422. |
- Wåhlander, Martin, 1982-, et al.
(författare)
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Hydrophobic matrix-free graphene-oxide composites with isotropic and nematic states
- 2016
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Ingår i: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 8, s. 14730-14745
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate a novel route to synthesise hydrophobic matrix-free composites of polymer-grafted graphene oxide (GO) showing isotropic or nematic alignment and shape-memory effects. For the first time, a cationic macroinitiator (MI) has been immobilised on anionic GO and subsequently grafted with hydrophobic polymer grafts. Dense grafts of PBA, PBMA and PMMA with a wide range of average graft lengths (MW: 1–440 kDa) were polymerised by surface-initiated controlled radical precipitation polymerisation from the statistical MI. The surface modification is designed similarly to bimodal graft systems, where the cationic MI generates nanoparticle repulsion, similar to dense short grafts, while the long grafts offer miscibility in non-polar environments and cohesion. The state-of-the-art dispersions of grafted GO were in the isotropic state. Transparent and translucent matrix-free GO-composites could be melt-processed directly using only grafted GO. After processing, birefringence due to nematic alignment of grafted GO was observed as a single giant Maltese cross, 3.4 cm across. Permeability models for composites containing aligned 2D-fillers were developed, which were compared with the experimental oxygen permeability data and found to be consistent with isotropic or nematic states. The storage modulus of the matrix-free GO-composites increased with GO content (50% increase at 0.67 wt%), while the significant increases in the thermal stability (up to 130 °C) and the glass transition temperature (up to 17 °C) were dependent on graft length. The tuneable matrix-free GO-composites with rapid thermo-responsive shape-memory effects are promising candidates for a vast range of applications, especially selective membranes and sensors.
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| 224423. |
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| 224424. |
- Wåhlin, Anders, 1983-
(författare)
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Cerebral blood flow and intracranial pulsatility studied with MRI : measurement, physiological and pathophysiological aspects
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- During each cardiac cycle pulsatile arterial blood inflates the vascular bed of the brain, forcing cerebrospinal fluid (CSF) and venous blood out of the cranium. Excessive arterial pulsatility may be part of a harmful mechanism causing cognitive decline among elderly. Additionally, restricted venous flow from the brain is suggested as the cause of multiple sclerosis. Addressing hypotheses derived from these observations requires accurate and reliable investigational methods. This work focused on assessing the pulsatile waveform of cerebral arterial, venous and CSF flows. The overall aim of this dissertation was to explore cerebral blood flow and intracranial pulsatility using MRI, with respect to measurement, physiological and pathophysiological aspects. Two-dimensional phase contrast magnetic resonance imaging (2D PCMRI) was used to assess the pulsatile waveforms of cerebral arterial, venous and CSF flow. The repeatability was assessed in healthy young subjects. The 2D PCMRI measurements of cerebral arterial, venous and CSF pulsatility were generally repeatable but the pulsatility decreased systematically during the investigation. A method combining 2D PCMRI measurements with invasive CSF infusion tests to determine the magnitude and distribution of compliance within the craniospinal system was developed and applied in a group of healthy elderly. The intracranial space contained approximately two thirds of the total craniospinal compliance. The magnitude of craniospinal compliance was less than suggested in previous studies. The vascular hypothesis for multiple sclerosis was tested. Venous drainage in the internal jugular veins was compared between healthy controls and multiple sclerosis patients using 2D PCMRI. For both groups, a great variability in the internal jugular flow was observed but no pattern specific to multiple sclerosis could be found. Relationships between regional brain volumes and potential biomarkers of intracranial cardiac-related pulsatile stress were assessed in healthy elderly. The biomarkers were extracted from invasive CSF pressure measurements as well as 2D PCMRI acquisitions. The volumes of temporal cortex, frontal cortex and hippocampus were negatively related to the magnitude of cardiac-related intracranial pulsatility. Finally, a potentially improved workflow to assess the volume of arterial pulsatility using time resolved, four-dimensional phase contrast MRI measurements (4D PCMRI) was evaluated. The measurements showed good agreement with 2D PCMRI acquisitions. In conclusion, this work showed that 2D PCMRI is a feasible tool to study the pulsatile waveforms of cerebral blood and CSF flow. Conventional views regarding the magnitude and distribution of craniospinal compliance was challenged, with important implications regarding the understanding of how intracranial vascular pulsatility is absorbed. A first counterpoint to previous near-uniform observations of obstructions in the internal jugular veins in multiple sclerosis was provided. It was demonstrated that large cardiac- related intracranial pulsatility were related to smaller volumes of brain regions that are important in neurodegenerative diseases among elderly. This represents a strong rationale to further investigate the role of excessive intracranial pulsatility in cognitive impairment and dementia. For that work, 4D PCMRI will facilitate an effective analysis of cerebral blood flow and pulsatility.
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| 224425. |
- Wåhlin, Anders, et al.
(författare)
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Mekanikundervisning i smågrupper
- 2001
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Ingår i: Kvalitetskonferens 2001. - : Högskoleverket.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 224426. |
- Wåhlin, Anders, et al.
(författare)
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On structure-borne sound : experiments showing the initial transient acoustic wave field generated by an impacted plate
- 1994
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Ingår i: Journal of the Acoustical Society of America. - : Acoustical Society of America (ASA). - 0001-4966 .- 1520-8524. ; 96:5, s. 2791-2797
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Tidskriftsartikel (refereegranskat)abstract
- The initial propagating transient acoustic field in air generated by an impacted plate is visualized. The transient traveling flexural waves in the plate created by the impact are shown, simultaneously. The experiments are performed using double pulsed holographic interferometry. It is shown that flexural waves in a plate act as a series of traveling acoustic sources. Since the flexural waves in the plate are dispersive the trace matched acoustical waves further away from the impact source propagate at a smaller angle relative to the plate than those closer to the impact. An observer situated close to the plate and away from the impact point will first receive high-frequency components of the sound. A quantitative evaluation of the acoustic field also shows that if there is a transient increase in pressure on one side of the plate there will be a similar decrease on the other side.
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| 224427. |
- Wåhlin, Anders, et al.
(författare)
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Phase contrast MRI quantification of pulsatile volumes of brain arteries, veins, and cerebrospinal fluids compartments : repeatability and physiological interactions
- 2012
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Ingår i: Journal of Magnetic Resonance Imaging. - : John Wiley & Sons. - 1053-1807 .- 1522-2586. ; 35:5, s. 1055-1062
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To study measurement repeatability and physiological determinants on measurement stability for phase contrast MRI (PC-MRI) measurements of cyclic volume changes (ΔV) of brain arteries, veins, and cerebrospinal fluid (CSF) compartments.MATERIALS AND METHODS: Total cerebral blood flow (tCBF), total internal jugular flow (tJBF) and spinal CSF flow at C2-C3 level and CSF in the aqueduct was measured using five repetitions in 20 healthy subjects. After subtracting net flow, waveforms were integrated to calculate ΔV of arterial, venous, and cerebrospinal fluid compartments. The intraclass correlation coefficient (ICC) was used to measure repeatability. Systematic errors were investigated by a series of phantom measurements.RESULTS: For ΔV calculated from tCBF, tJBF and both CSF waveforms, the ICC was ≥0.85. ΔV from the tCBF waveform decreased linearly between repetitions (P = 0.012). Summed CSF and venous volume being shifted out from the cranium was correlated with ΔV calculated from the tCBF waveform (r = 0.75; P < 0.001). Systematic errors increased at resolutions <4 pixels per diameter.CONCLUSION: Repeatability of ΔV calculated from tCBF, tJBF, and CSF waveforms allows useful interpretations. The subject's time in the MR system and imaging resolution should be considered when interpreting volume changes. Summed CSF and venous volume changes was associated with arterial volume changes.J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc.
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| 224428. |
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| 224429. |
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| 224430. |
- Wåhlin, Anders, et al.
(författare)
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Wave propagation in plates studied by pulsed hologram interferometry
- 1989
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Ingår i: The Sixth Meeting in Israel on Optical Engineering. - Bellingham, Wash : SPIE - International Society for Optical Engineering. ; , s. 146-53
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Konferensbidrag (refereegranskat)abstract
- Isotropic and non-isotropic plates are impacted by a ballistic pendulum. The bending waves that are generated are studied with holographic interferometry using a double pulsed ruby laser as light source. The pulse shape changes with time because of the dispersivity of the waves. Initially the fringe pattern in the isotropic case is cylindrically symmetric and determined from an initial value problem. Later, when the waves have reached the plate rim, in- and outgoing waves gradually develop fringe patterns which in the end will be a combination of eigenmodes of the plate. A solution to the corresponding Kirchhoff plate equation is presented, which in the special case when the impact is modelled as a Dirac-pulse in space and time, is shown to depend only of the distance to the impact point divided by the square root of the time after impact and a parameter containing plate parameters. From the slope of the central deflection material parameters can be determined. Another solution, assuming a finite impact time, is shown to agree better with experiments. Results from investigations of non-isotropic materials are also presented.
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