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Sökning: hsv:(TEKNIK OCH TEKNOLOGIER) hsv:(Medicinteknik)

  • Resultat 5031-5040 av 6209
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5031.
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5032.
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5033.
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5034.
  • Fornell, A., et al. (författare)
  • Experimental investigation of resonance conditions for particle focusing in droplet acoustofluidics
  • 2016
  • Ingår i: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. - 9780979806490 ; , s. 719-720
  • Konferensbidrag (refereegranskat)abstract
    • We have experimentally studied the conditions for acoustic particle focusing inside aqueous droplets in two-phase-systems, and confirmed our findings by theoretical analysis. The results show that the acoustic properties of the two fluids have to be matched to achieve strong acoustic resonance and focusing in the system.
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5035.
  • Fornell, Anna, et al. (författare)
  • Improved acoustic particle enrichment in droplets by optimising the droplet split design
  • 2019
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Droplet microfluidics has emerged as a valuable platform for miniaturisation of biological experiments on-chip. In droplet microfluidic chips monodisperse droplets containing cells or other bioparticles can be generated at high throughput, and each droplet can be used as an isolated reaction chamber for individual measurements. A general trend in droplet microfluidics is reducing the size of the droplets, but the challenge is maintaining the particles in the droplets after splitting. We have previously reported on an acoustofluidic chip where bulk acoustic waves were used to control particle positioning in a trident-shaped droplet split. However, the reported particle enrichment was modest (3-fold), and the aim of this study is to increase the particle enrichment by optimising the droplet split design. With our new optimised droplet split we show up to 16.7-fold particle enrichment with high particle recovery.
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5036.
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5037.
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5038.
  • Fornell, Anna, et al. (författare)
  • Trapping of Cell-Laden Hyaluronic Acid-Acrylamide Hydrogel Droplets using Bulk Acoustic Waves
  • 2019
  • Ingår i: 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). - : IEEE. - 9781538681046 - 9781728120072 ; , s. 2352-2355
  • Konferensbidrag (refereegranskat)abstract
    • In this paper an acoustofluidic system to trap hydrogel droplets is shown. The presented trapping method is label-free, biocompatible and operated in non-contact mode. The results show that the droplets can be trapped at flow rates up to 76 mu L/min which corresponds to an average flow speed of 3.2 mm/s. Moreover, it is shown that the droplets can be trapped for several hours, thus allowing for studies of the encapsulated cells over time. An application of the system is shown by performing on-chip cell nuclei staining.
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5039.
  • Fors, Carina, et al. (författare)
  • Analysis of breathing-related variations in ECG-triggered laser Doppler perfusion signals measured on the beating heart during surgery
  • 2006
  • Ingår i: Computers in cardiology. - 0276-6574. ; 33, s. 181-184
  • Tidskriftsartikel (refereegranskat)abstract
    • Laser Doppler perfusion monitoring (LDPM) is amethod to assess microvascular perfusion. A modified,ECG-triggered LDPM system has been developed tomeasure myocardial perfusion with minimum influencefrom heart motion. With this method, one systolic (PLS)and one diastolic (PLD) perfusion value is obtained.The aim of this study was to analyse breathing-relatedvariations in PLS and PLD measured during open-heartsurgery. The phase delays between PLS, PLD, meanarterial blood pressure (MAP), heart rate and, indirectly,the respiration were determined.MAP tended to be in phase with or precede thevariations in PLD, i.e., PLD was at a maximum at the endof inspiration or at the beginning of expiration. No clearrelation between PLS and any of the other signals couldbe found.
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5040.
  • Fors, Carina, 1978- (författare)
  • Evaluation of a Laser Doppler System for Myocardial Perfusion Monitoring
  • 2007
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Coronary artery bypass graft (CABG) surgery is a common treatment for patients with coronary artery disease. A potential complication of CABG is myocardial ischemia or infarction. In this thesis, a method - based on laser Doppler flowmetry (LDF) - for detection of intra- and postoperative ischemia by myocardial perfusion monitoring is evaluated.LDF is sensitive to motion artifacts. In previous studies, a method for reduction of motion artifacts when measuring on the beating heart has been developed. By using the ECG as a reference, the perfusion signal is measured in intervals during the cardiac cycle where the cardiac motion is at a minimum, thus minimizing the artifacts in the perfusion signal.The aim of this thesis was to investigate the possibilities to use the ECG-triggered laser Doppler system for continuous monitoring of myocardial perfusion in humans during and after CABG surgery. Two studies were performed. In the first study, changes in myocardial perfusion during CABG surgery were investigated (n = 13), while the second study focused on postoperative measurements (n = 13). In addition, an ECG-triggering method was implemented and evaluated.It was found that the large variations in myocardial perfusion during CABG surgery could be monitored with the ECG-triggered laser Doppler system. Furthermore, a perfusion signal of good quality could be registered postoperatively from the closed chest in ten out of thirteen patients. In eight out of ten patients, a proper signal was obtained also the following morning, i.e., about 20 hours after probe insertion. The results show that respiration and blood pressure can have an influence on the perfusion signal.In conclusion, the results indicate that the method is able to detect fluctuations in myocardial perfusion under favourable circumstances. However, high heart rate, abnormal cardiac motion, improper probe attachment and limitations in the ECG-triggering method may result in variations in the perfusion signal that are not related to tissue perfusion.
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