| 17021. |
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| 17022. |
- Axelsson, K. F., et al.
(författare)
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Fracture Risk After Gastric Bypass Surgery : A Retrospective Cohort Study
- 2018
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Ingår i: Osteoporosis International. - : Springer London. - 0937-941X .- 1433-2965. ; 29:Suppl. 1, s. S491-S491
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Objectives: Gastric bypass surgery constitutes the most common and effective bariatric surgery to treat obesity. Gastric bypass leads to bone oss but fracture risk following surgery has been insufficiently studied. Our objective was to investigate if gastric bypass surgery in obese patients, with and without diabetes, was associated with fracture risk, and if the fracture risk was associated with post-surgery weight loss or insufficient calcium and vitamin D supplementation.Methods: Using large databases, 38 971 obese patients undergoing gastric bypass were identified, 7758 with diabetes and 31 213 without. Through multivariable 1:1 propensity score matching, well-balanced controls were identified. The risk of fracture and fall injury was investigated using Cox proportional hazards and flexible parameter models. Fracture risk according to weight loss and degree of calcium and vitamin D supplementation one year post-surgery was investigated.Results: 77 942 patients had a median and total follow-up time of 3.1 (IQR 1.7-4.6) and 251 310 person-years, respectively. Gastric bypass was associated with increased risk of any fracture, in patients with diabetes and without diabetes using a multivariable Cox model (HR 1.26, 95%CI 1.05-1.53 and HR 1.32, 95%CI 1.18-1.47, respectively). The risk of fall injury without fracture was also increased after gastric bypass, both in patients with (HR 1.26 95%CI 1.04-1.52) and without diabetes (HR 1.24 95%CI 1.12-1.38). Weight loss or degree of calcium and vitamin D supplementation after gastric bypass were not associated with fracture risk.Conclusions: Gastric bypass was associated with an increased risk of fracture and fall injury. Weight loss or calcium and vitamin D supplementation following surgery were not associated with fracture risk. These findings indicate that gastric bypass increases fracture risk, which could at least partly be due to increased susceptibility to falls.
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| 17023. |
- Axelsson, Kjell, et al.
(författare)
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Intraarticular administration of ketorolac, morphine, and ropivacaine combined with intraarticular patient-controlled regional analgesia for pain relief after shoulder surgery : a randomized, double-blind study
- 2008
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Ingår i: Anesthesia and Analgesia. - : Lippincott Williams & Wilkins. - 0003-2999 .- 1526-7598. ; 106:1, s. 328-333
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In this study we assessed the efficacy of intraarticular regional analgesia on postoperative pain and analgesic requirements. METHODS: Fifty-one patients undergoing shoulder surgery (Bankart) were recruited into this double-blind study. At the end of the operation, patients were randomized to three groups to receive intraarticularly via a catheter: Group 1: ropivacaine 90 mg (9 mL), morphine 4 mg (10 mL), and ketorolac 30 mg (1 mL) (total volume 20 mL); Groups 2 and 3: saline (20 mL). In addition, Groups 1 and 3 received 1 mL saline IV while Group 2 received ketorolac 30 mg (1 mL) IV. Postoperatively, Group 1 received pain relief using 10 mL 0.5% ropivacaine on demand via the intraarticular catheter while Groups 2 and 3 received 10 mL of saline intraarticularly. Group 3 was the Control group. RESULTS: Postoperative pain at rest and on movement were lower in Group 1 than in Groups 2 and 3 during the first 30 and 120 min, respectively. The time to first request for local anesthetic infusion was longer in Group 1 than in Groups 2 and 3 (P < 0.001). The median morphine consumption during the first 24 postoperative hours was less in Groups 1 and 2 than in Group 3 (P < 0.001). There was no significant difference in analgesic consumption between Group 1 and Group 2. The median satisfaction score was higher in Group 1 compared with Groups 2 (P < 0.05) and 3 (P < 0.001). CONCLUSIONS: A combination of intraarticular ropivacaine, morphine, and ketorolac followed by intermittent injections of ropivacaine as needed provided better pain relief, less morphine consumption, and improved patient satisfaction compared with the control group. The group that received IV ketorolac consumed less morphine and was more satisfied with treatment than patients in the control group.
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| 17024. |
- Axelsson, Linda, et al.
(författare)
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Samtalsminnen inom polisförhör med barn och ungdomar
- 1997
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet är att undersöka vilka kategorier av samtalsminnen som förekommer hos förhörsledare och hos förhörda barn. Totalt 20 förhörsutskrifter med barn och ungdomar granskades. Ett kategorisystem redovisas över förhörsledares olika varianter av samtalsminnen och två kategorisystem redovisas över de förhördas olika varianter av samtalsminnen inom och utom förhörssituationen.
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| 17025. |
- Axelsson, Maija, et al.
(författare)
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Dags att städa ut vintern
- 2015
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Ingår i: Familjär. - Stockholm : AB Familjebostäder. ; :1, s. 4-7
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 17026. |
- Axelsson, Maria, et al.
(författare)
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Press i utredande samtal med barn
- 1999
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Förskolebarn (N = 32; pojkar och flickor 3 respektive 5 år gamla) intervjuades dels neutralt och dels med någon press. Resultatet påvisade en påtaglig förändring i svarsmönster vid införande av press.
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| 17027. |
- Axelsson, Patric, et al.
(författare)
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Betamethasone does not prevent nausea and vomiting induced by the dopamine-agonist apomorphine
- 2006
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Ingår i: Canadian Journal of Anesthesia. - 0832-610X .- 1496-8975. ; 53:4, s. 370-374
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The mechanism of the antiemetic actions of corticosteroids is not known. The purpose of this study was to evaluate if betamethasone can prevent nausea, vomiting or increase of vasopressin induced by apomorphine. Metoclopramide, a dopamine antagonist, was used as a control substance. METHODS: Ten healthy volunteers were studied on three occasions. In a randomized order they were allocated to receive pretreatment with betamethasone 8 mg iv, metoclopramide 10 mg iv, and normal saline 2 mL as placebo on the three different occasions, 15 min before the administration of apomorphine 30 microg x kg(-1) s.c.. After administration of apomorphine, episodes of vomiting were recorded, and the intensity of nausea was estimated by the subject on a visual analogue scale (VAS 0-10 cm). Blood samples for analysis of plasma concentrations of vasopressin were analyzed. RESULTS: One volunteer decided to withdraw, as he experienced akathisia after receiving metoclopramide. During the first two hours after apomorphine, eight of nine volunteers vomited both after betamethasone and placebo. One volunteer did not vomit after betamethasone and placebo but he experienced nausea. None of the volunteers vomited after metoclopramide (P < 0.01 vs betamethasone and placebo). The maximum VAS for nausea was significantly higher after betamethasone and placebo compared to metoclopramide (P < 0.01). The vasopressin levels increased after betamethasone and placebo, but there was no increase in any volunteer after pretreatment with metoclopramide. CONCLUSION: This study demonstrates that betamethasone does not prevent nausea, vomiting and increase of vasopressin induced by apomorphine, whereas metoclopramide prevents apomorphine-induced emesis. Our work suggests that betamethasone does not have dopamine-antagonistic effects.
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| 17028. |
- Axelsson, Susanne, et al.
(författare)
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A combination of the activation marker CD86 and the immune checkpoint marker B and T lymphocyte attenuator (BTLA) indicates a putative permissive activation state of B cell subtypes in healthy blood donors independent of age and sex
- 2020
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Ingår i: BMC Immunology. - : BioMed Central (BMC). - 1471-2172. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The use of anti-B cell based therapies in immune-mediated diseases targeting general B cell markers or molecules important for B cell function has increased the clinical needs of monitoring B cell subpopulations.RESULTS: We analyzed the expression profile of cell surface markers CD86 and B and T lymphocyte attenuator (BTLA) in B cell subtypes using flow cytometry, including naïve, transitional, switched memory, non-switched memory and double-negative memory B cells and plasmablasts, and investigated the dependence of age and sex in a healthy adult blood donor population. The switched memory B cell subtype displayed a divergent expression of the markers, with increased CD86 and decreased BTLA as compared to non-switched and double negative memory cells, as well as compared to naïve B cells. Plasmablasts expressed highly increased CD86 compared to all other subtypes and a decreased expression of BTLA compared to naïve cells, but still higher compared to the memory cell populations. Transitional B cells had CD86 and BTLA expression similar to the other naïve cells.CONCLUSIONS: We show divergent expression of CD86 and BTLA in memory cells and plasmablasts compared to naïve B cells independent of age and sex. Furthermore, a similarly divergent difference of expression pattern was seen between the memory cell subtypes, altogether indicating that the combination of CD86 and BTLA might be markers for a permissive activation state. We suggest the combination of CD86 and BTLA expression on B cell subtypes as a potentially important tool in monitoring the status of B cell subtypes before and after treatments influencing the B cell compartment.
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| 17029. |
- Axelsson, Tobias, 1979-
(författare)
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Att tolka och praktisera jämställdhet i förskola och grundskola : Slutrapport av projektet Forskningsbaserad samverkan – med målet att förbättra jämställdhetsarbetet i Askersunds kommuns förskolor och grundskolor
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport är att beskriva och problematisera hur jämställdhet uppfattas och hur jämställdhetsarbete bedrivs i förskola och grundskola. Rapporten har gjorts i och på uppdrag från Askersunds kommun och behandlar följande forskningsfrågor:1. Vilka förståelser och upplevelser av jämställdhet och ojämställdhet har elever?2. Hur uppfattar pedagoger sitt jämställdhetsuppdrag?3. Hur praktiserar pedagoger sitt jämställdhetsuppdrag?4. Vilka förståelser finns av jämställdhet i centrala dokument om förskola och grundskola på kommunal nivå?Utifrån 28 observationsdagar (i årskurs två, fem och nio), nitton intervjuer (med arbetslag i grundskola, pedagoger i förskola och grundskola samt elever i årskurs nio) och dokumentanalyser undersöks särskilt hur pedagoger tolkar och praktiserar jämställdhet. Rapportens resultat visar: 1) att elever är positivt inställda till jämställdhet och har erfarenheter av ojämställdhet, 2) att det finns stora skillnader mellan om och hur pedagoger tolkar jämställdhetsuppdraget, 3) att pedoger varierar mellan att använda sig att könsavkodade och reflexiva/synliggörande jämställdhetsstrategier, 4) att jämställdhet förstås dels som en administrativ rutinåtgärd och dels som ett problemorienterat arbete. Rapporten rekommenderar ett intersektionellt jämställdhetsarbete som pendlar mellan att betrakta utbildning som, om respektive för jämställdhet.
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| 17030. |
- Axelsson, Tobias, 1979-
(författare)
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Del 1: Föräldraskapsstöd och jämställdhet. [Inspelad föreläsning]
- 2020
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Annan publikation (populärvet., debatt m.m.)abstract
- Det här är den första föreläsningen i en serie av tre föreläsningar om jämställt föräldraskapsstöd. Föreläsningarna har gjorts på uppdrag av Länsstyrelserna. Denna föreläsning berör relationen mellan föräldraskapsstödspolitik och jämställdhetspolitik.
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