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Sökning: swepub > Larsson Anders > Tidskriftsartikel

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711.
  • Lannergård, Anders, et al. (författare)
  • The time course of body temperature, serum amyloid A protein, C-reactive protein and interleukin-6 in patients with bacterial infection during the initial 3 days of antibiotic therapy
  • 2009
  • Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 41:9, s. 663-671
  • Tidskriftsartikel (refereegranskat)abstract
    • The accuracy of using body temperature, serum amyloid A (SAA), C-reactive protein (CRP) and interleukin-6 (IL-6) in the work-up for early or late step-down therapy after an initial course of intravenous cefuroxime was investigated. Eighty-one hospitalized patients with an initial course of cefuroxime were retrospectively classified with one of the following diagnoses: bacterial infection without known focus, pneumonia, bronchitis, pyelonephritis, skin and soft-tissue infections or fever of other origin. The majority of the patients had sepsis (91% or 74/81) of whom 6 patients had severe sepsis. The inter-individual variability of body temperature, SAA, CRP and IL-6 was considerable. The time course of SAA and CRP during the first 24 h in patients with sepsis with a short duration of illness but without septic shock showed increasing levels during the initial course of intravenous therapy. In contrast, body temperature and IL-6 decreased, regardless of illness duration. Beyond 24 h, all 4 biomarkers declined, again regardless of the duration of illness. After the initial course of cefuroxime, biomarkers were non-distinguishing in terms of guidance in the judgement of early or late step-down therapy. Further studies are proposed for biomarker guidance antibiotic therapy in sepsis patients without septic shock.
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  • Larsson, Anders (författare)
  • AliView: a fast and lightweight alignment viewer and editor for large data sets
  • 2014
  • Ingår i: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811. ; 30:22, s. 3276-3278
  • Tidskriftsartikel (refereegranskat)abstract
    • Summary: AliView is an alignment viewer and editor designed tomeet the requirements of next generation sequencing era phyloge-netic datasets. AliView handles alignments of unlimited size in theformats most commonly used, i.e. Fasta, Phylip, Nexus, Clustal andMSF. The intuitive graphical interface makes it easy to inspect, sort,delete, merge and realign sequences as part of the manual filteringprocess of large data sets. AliView also works as an easy to usealignment editor for small as well as large data sets.Availability: AliView is released as open-source software under theGNU General Public License, version 3.0 (GPLv3), and is availableat GitHub (www.github.com/AliView). The program is cross-platformand extensively tested on Linux, Mac OS X and Windows systems.Downloads and help are available at http://ormbunkar.se/aliviewContact: anders.larsson@ebc.uu.seSupplementary information:
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