Search: onr:"swepub:oai:DiVA.org:uu-223998" >
Nordic MCL-3 study :
Nordic MCL-3 study : 90Y-ibritumomab-tiuxetan added to BEAM/C in non-CR patients before transplant in mantle cell lymphoma
-
Kolstad, Arne (author)
-
- Laurell, Anna (author)
- Uppsala universitet,Enheten för onkologi
-
- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
show more...
-
Grønbæk, Kirsten (author)
-
- Elonen, Erkki (author)
- Karolinska Institutet
-
Räty, Riikka (author)
-
Pedersen, Lone Bredo (author)
-
Loft, Annika (author)
-
Bogsrud, Trond Velde (author)
-
Kimby, Eva (author)
-
Hansen, Per Boye (author)
-
Fagerli, Unn Merete (author)
-
Nilsson-Ehle, Herman (author)
-
Lauritzsen, Grete Fossum (author)
-
Lehmann, Anne Kristine (author)
-
- Sundström, Christer (author)
- Uppsala universitet,Molekylär och morfologisk patologi
-
Karjalainen-Lindsberg, Marja-Liisa (author)
-
Ralfkiaer, Elisabeth (author)
-
- Ehinger, Mats (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Delabie, Jan (author)
-
Bentzen, Hans (author)
-
Schildt, Jukka (author)
-
- Kostova-Aherdan, Kamelia (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
Frederiksen, Henrik (author)
-
Brown, Peter de Nully (author)
-
Geisler, Christian H (author)
-
Gronbaek, Kirsten (author)
-
show less...
-
(creator_code:org_t)
- American Society of Hematology, 2014
- 2014
- English.
-
In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 123:19, s. 2953-2959
- Related links:
-
https://europepmc.or...
-
show more...
-
https://portal.resea... (primary) (free)
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- The main objective of the MCL3 study was to improve outcome for patients not in CR before transplant by adding (90)Y-ibritumomab-tiuxetan (Zevalin) to the high-dose regimen. 160 consecutive, untreated stage II-IV MCL patients < 66 years received rituximab (R)- maxi-CHOP alternating with R-high-dose Ara-C (6 cycles total), followed by high-dose BEAM or BEAC and autologous stem cell transplantation 2005-2009. Zevalin (0.4 mCi/kg) was given to responders in only CRu/PR prior to high-dose therapy. The overall response rate (ORR) pre-transplant was 97%. After a median follow-up of 4.4 years the outcome did not differ from that of the historic control, the MCL2 trial with the same treatment except for Zevalin. Overall (OS), event free (EFS), and progression-free survival (PFS) at 4 years were 78, 62 and 71%, respectively. For patients in CRu/PR before transplant who received Zevalin duration of response was shorter than in the CR group. Inferior PFS, EFS- and OS were predicted by PET-positivity pre-transplant and detectable minimal residual disease (MRD) before and after transplant. In conclusion, a positive PET prior to transplant and MRD are strong predictors of outcome. Late intensification with Zevalin may be too late to improve the outcome of patients not in CR before transplant.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Blood
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Kolstad, Arne
-
Laurell, Anna
-
Jerkeman, Mats
-
Grønbæk, Kirsten
-
Elonen, Erkki
-
Räty, Riikka
-
show more...
-
Pedersen, Lone B ...
-
Loft, Annika
-
Bogsrud, Trond V ...
-
Kimby, Eva
-
Hansen, Per Boye
-
Fagerli, Unn Mer ...
-
Nilsson-Ehle, He ...
-
Lauritzsen, Gret ...
-
Lehmann, Anne Kr ...
-
Sundström, Chris ...
-
Karjalainen-Lind ...
-
Ralfkiaer, Elisa ...
-
Ehinger, Mats
-
Delabie, Jan
-
Bentzen, Hans
-
Schildt, Jukka
-
Kostova-Aherdan, ...
-
Frederiksen, Hen ...
-
Brown, Peter de ...
-
Geisler, Christi ...
-
Gronbaek, Kirste ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
- Articles in the publication
-
Blood
- By the university
-
Uppsala University
-
Lund University
-
Karolinska Institutet