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Amyloid-β associate...
Amyloid-β associated volume loss occurs only in the presence of phospho-tau.
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Desikan, Rahul S (author)
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McEvoy, Linda K (author)
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Thompson, Wesley K (author)
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Holland, Dominic (author)
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Roddey, J Cooper (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Aisen, Paul S (author)
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Brewer, James B (author)
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Hyman, Bradley T (author)
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Dale, Anders M (author)
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(creator_code:org_t)
- 2011-10-14
- 2011
- English.
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In: Annals of neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 70:4, s. 657-61
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid-β (Aβ) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p-tau(181p) and CSF Aβ(1-42) . We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF Aβ(1-42) only with elevated CSF p-tau(181p) . Our findings indicate that Aβ-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Aged
- Aged
- 80 and over
- Amnesia
- cerebrospinal fluid
- pathology
- Amyloid beta-Peptides
- cerebrospinal fluid
- Atrophy
- Cerebral Cortex
- pathology
- Female
- Humans
- Longitudinal Studies
- Male
- Mild Cognitive Impairment
- cerebrospinal fluid
- pathology
- Peptide Fragments
- cerebrospinal fluid
- tau Proteins
- cerebrospinal fluid
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Desikan, Rahul S
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McEvoy, Linda K
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Thompson, Wesley ...
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Holland, Dominic
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Roddey, J Cooper
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Blennow, Kaj, 19 ...
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show more...
-
Aisen, Paul S
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Brewer, James B
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Hyman, Bradley T
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Dale, Anders M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Annals of neurol ...
- By the university
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University of Gothenburg