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Joint Analysis of P...
Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
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Maier, R. (författare)
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Moser, G. (författare)
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Chen, G. B. (författare)
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visa fler...
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Ripke, S. (författare)
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Coryell, W. (författare)
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Potash, J. B. (författare)
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Scheftner, W. A. (författare)
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Shi, J. X. (författare)
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Weissman, M. M. (författare)
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- Hultman, C. M. (författare)
- Karolinska Institutet
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- Landén, Mikael, 1966 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Levinson, D. F. (författare)
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Kendler, K. S. (författare)
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Smoller, J. W. (författare)
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Wray, N. R. (författare)
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Lee, S. H. (författare)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 96:2, s. 283-294
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk. However, for polygenic traits, such as psychiatric disorders, the accuracy of risk prediction is low. Here we use a multivariate linear mixed model and apply multi-trait genomic best linear unbiased prediction for genetic risk prediction. This method exploits correlations between disorders and simultaneously evaluates individual risk for each disorder. We show that the multivariate approach significantly increases the prediction accuracy for schizophrenia, bipolar disorder, and major depressive disorder in the discovery as well as in independent validation datasets. By grouping SNPs based on genome annotation and fitting multiple random effects, we show that the prediction accuracy could be further improved. The gain in prediction accuracy of the multivariate approach is equivalent to an increase in sample size of 34% for schizophrenia, 68% for bipolar disorder, and 76% for major depressive disorders using single trait models. Because our approach can be readily applied to any number of GWAS datasets of correlated traits, it is a flexible and powerful tool to maximize prediction accuracy. With current sample size, risk predictors are not useful in a clinical setting but already are a valuable research tool, for example in experimental designs comparing cases with high and low polygenic risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- GENOME-WIDE ASSOCIATION
- RESTRICTED MAXIMUM-LIKELIHOOD
- AVERAGE
- INFORMATION
- GENETIC RISK
- LOCI
- SELECTION
- TRAITS
- MODELS
- IDENTIFICATION
- POPULATION
- Genetics & Heredity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Maier, R.
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Moser, G.
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Chen, G. B.
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Ripke, S.
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Coryell, W.
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Potash, J. B.
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visa fler...
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Scheftner, W. A.
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Shi, J. X.
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Weissman, M. M.
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Hultman, C. M.
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Landén, Mikael, ...
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Levinson, D. F.
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Kendler, K. S.
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Smoller, J. W.
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Wray, N. R.
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Lee, S. H.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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American Journal ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet