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On the Origin of Ce...
On the Origin of Cells and Derivation of Thyroid Cancer: C Cell Story Revisited
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Williams, D. (författare)
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- Nilsson, Mikael, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Sahlgrenska Cancer Center,Institute of Biomedicine
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(creator_code:org_t)
- 2016-06-24
- 2016
- Engelska.
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Ingår i: European Thyroid Journal. - : Bioscientifica. - 2235-0640 .- 2235-0802. ; 5:2, s. 79-93
- Relaterad länk:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We will highlight and put into perspective new lineage tracing data from genetic studies in mice indicating that the genuine progenitors to C cells arise in the endoderm germ layer. This overturns the current concept of a neural crest origin of thyroid C cells referred to in every textbook and dedicated paper to this very day. As will become apparent, except for a single experiment, the neural crest theory has little or no support when the evolution and development of calcitonin-producing cells in the entire chordate family are considered. Instead, a unifying origin of all cells of the ultimobranchial bodies reopens questions on the histogenesis of certain thyroid pathologies previously difficult to explain. On this aspect, medullary thyroid cancer shows a stronger connection to gut neuroendocrine tumours than previously recognized. It is envisaged that novel factors implicated in C cell-derived tumour growth and progression will be discovered as the mechanisms that regulate lineage expansion of embryonic C cell precursors from pharyngeal endoderm are uncovered. We will not discuss why C cells go to the bother of burying themselves in the thyroid - this remains a mystery. (C) 2016 European Thyroid Association Published by S. Karger AG, Basel
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Endoderm
- Mixed medullary-follicular carcinoma
- Neural crest
- Neuroendocrine tumours
- Thyroid C
- NEURAL CREST ORIGIN
- ENDOCRINE NEOPLASIA TYPE-2
- CALCITONIN-PRODUCING
- CELLS
- UNILATERAL RENAL AGENESIS
- OF-THE-LITERATURE
- MIXED MEDULLARY
- RET PROTOONCOGENE
- ULTIMOBRANCHIAL GLANDS
- FOLLICULAR CARCINOMA
- TRANSGENIC MICE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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