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Genetic variants li...
Genetic variants linked to education predict longevity.
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Marioni, Riccardo E (author)
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Ritchie, Stuart J (author)
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Joshi, Peter K (author)
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Hagenaars, Saskia P (author)
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Okbay, Aysu (author)
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Fischer, Krista (author)
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Adams, Mark J (author)
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Hill, W David (author)
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Davies, Gail (author)
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Nagy, Reka (author)
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Amador, Carmen (author)
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Läll, Kristi (author)
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Metspalu, Andres (author)
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Liewald, David C (author)
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Campbell, Archie (author)
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Wilson, James F (author)
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Hayward, Caroline (author)
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Esko, Tõnu (author)
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Porteous, David J (author)
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Gale, Catharine R (author)
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Deary, Ian J (author)
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- Jacobsson, Bo, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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(creator_code:org_t)
- 2016-10-31
- 2016
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 113:47, s. 13366-13371
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Abstract
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- Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Marioni, Riccard ...
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Ritchie, Stuart ...
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Joshi, Peter K
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Hagenaars, Saski ...
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Okbay, Aysu
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Fischer, Krista
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show more...
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Adams, Mark J
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Hill, W David
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Davies, Gail
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Nagy, Reka
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Amador, Carmen
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Läll, Kristi
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Metspalu, Andres
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Liewald, David C
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Campbell, Archie
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Wilson, James F
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Hayward, Carolin ...
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Esko, Tõnu
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Porteous, David ...
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Gale, Catharine ...
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Deary, Ian J
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Jacobsson, Bo, 1 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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Proceedings of t ...
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Proceedings of t ...
- By the university
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University of Gothenburg
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Karolinska Institutet