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Sense-antisense lnc...
Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory axis
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- Mondal, Tanmoy, 1981 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy
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- Juvvuna, Prasanna Kumar (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy
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- Kirkeby, Agnete (author)
- Lund University,Lunds universitet,Human neural utvecklingsbiologi,Forskargrupper vid Lunds universitet,Human Neural Developmental Biology,Lund University Research Groups,University of Copenhagen
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- Mitra, Sanhita (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy
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- Kosalai, Subazini Thankaswamy, 1980 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy
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- Traxler, Larissa (author)
- Lund University
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- Hertwig, Falk (author)
- University Hospital of Cologne,Charité - University Medicine Berlin,University of Cologne
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- Wernig-Zorc, Sara (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy
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- Miranda, Caroline (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy
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- Deland, Lily (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Sahlgrenska Academy
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- Bartenhagen, Christoph (author)
- University Hospital of Cologne
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- Volland, Ruth (author)
- University Hospital of Cologne
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- Bartsch, Deniz (author)
- University of Cologne
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- Bandaru, Sashidar (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Engesser, Anne (author)
- University Hospital of Cologne
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- Subhash, Santhilal, 1987 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Martinsson, Tommy, 1956 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology
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- Carén, Helena, 1979 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Akyürek, Levent, 1966 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Pathology,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Kurian, Leo (author)
- University of Cologne
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- Kanduri, Meena, 1974 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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- Huarte, Maite (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
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- Kogner, Per (author)
- Karolinska Institutet
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- Fischer, Matthias (author)
- University Hospital of Cologne
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- Kanduri, Chandrasekhar, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 33:3
- Related links:
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http://www.cell.com/...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functional synergy between 6p22lncRNAs results in an undifferentiated state that is maintained by a gene-regulatory network, including SOX9 located on 17q, a region frequently gained in NB. 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene. This regulatory nexus between 6p22.3 and 17q regions may lead to potential NB treatment strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- lncRNA
- neuroblastoma
- long noncoding RNA
- Cancer
- epigenetics
- CASC15
- CHD7
- NBAT1
- neuronal differentiation
- SOX9
- ubiquitination
- USP36
Publication and Content Type
- ref (subject category)
- art (subject category)
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Mondal, Tanmoy, ...
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Juvvuna, Prasann ...
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Kirkeby, Agnete
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Mitra, Sanhita
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Kosalai, Subazin ...
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Traxler, Larissa
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Hertwig, Falk
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Wernig-Zorc, Sar ...
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Miranda, Carolin ...
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Deland, Lily
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Bartenhagen, Chr ...
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Volland, Ruth
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Bartsch, Deniz
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Bandaru, Sashida ...
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Engesser, Anne
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Subhash, Santhil ...
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Martinsson, Tomm ...
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Carén, Helena, 1 ...
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Akyürek, Levent, ...
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Kurian, Leo
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Kanduri, Meena, ...
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Huarte, Maite
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Kogner, Per
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Fischer, Matthia ...
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Kanduri, Chandra ...
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Cancer Cell
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet