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Joint health and tr...
Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B – The MoHem study
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- Måseide, Ragnhild J. (författare)
- University of Oslo,Oslo university hospital
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- Berntorp, Erik (författare)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups
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- Astermark, Jan (författare)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Skåne University Hospital
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- Olsson, Anna (författare)
- Sahlgrenska University Hospital
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- Bruzelius, Maria (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Frisk, Tony (författare)
- Karolinska Institutet
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- Nummi, Vuokko (författare)
- University of Helsinki,Helsinki University Central Hospital
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- Lassila, Riitta (författare)
- University of Helsinki,Helsinki University Central Hospital
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- Tjønnfjord, Geir E. (författare)
- University of Oslo,Oslo university hospital
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- Holme, Pål A. (författare)
- Oslo university hospital,University of Oslo
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(creator_code:org_t)
- 2020-07-27
- 2020
- Engelska 7 s.
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 26:5, s. 891-897
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: The prevalence of arthropathy in moderate haemophilia A (MHA) and B (MHB) is not well known. Aim: We evaluated joint health in Nordic patients in relation to their treatment modality. Methods: A cross-sectional, multicentre study covering MHA and MHB in Sweden, Finland and Norway. Arthropathy was evaluated by ultrasound (HEAD-US) and Haemophilia Joint Health Score (HJHS). Results: We report on 145 patients: median age 28 years (IQR 13-52) and 61% MHA. Baseline factor VIII/factor IX activity (FVIII/FIX:C) was 2 IU/dL (median) (IQR 2-4): lower for MHB (2 IU/dL, IQR 1-2) than MHA (3 IU/dL, IQR 2-4) (P <.01). Eighty-five per cent of MHA and 73% MHB had a history of haemarthrosis (P =.07). Age at first joint bleed was lower for MHA (5 years [median], IQR 3-7) than MHB (7 years, IQR 5-12) (P =.01). Thirty-eight per cent received prophylaxis, started at median 10 years of age (IQR 4-24). Median joint bleeds and serious other bleeds during the last 12 months were both zero (IQR 0-1). Total HEAD-US captured 0/48 points (median) (IQR 0-2) and HJHS 4/120 points (IQR 1-10) with strong correlation between them (r =.72). FVIII/FIX:C ≤ 3 IU/dL was associated with higher HJHS (P =.04). Fifteen per cent had undergone orthopaedic surgery. Conclusion: The current joint health in Nordic moderate haemophilia patients was rather good, but a subgroup had severe arthropathy. FVIII/FIX:C ≤ 3 IU/dL and MHA were associated with a more severe bleeding phenotype. We suggest primary prophylaxis to all patients with FVIII/FIX:C ≤ 3 IU/dL.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- arthropathy
- joint score
- moderate haemophilia A
- moderate haemophilia B
- prophylaxis
- ultrasound
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Måseide, Ragnhil ...
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Berntorp, Erik
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Astermark, Jan
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Olsson, Anna
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Bruzelius, Maria
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Frisk, Tony
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visa fler...
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Nummi, Vuokko
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Lassila, Riitta
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Tjønnfjord, Geir ...
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Holme, Pål A.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Haemophilia
- Av lärosätet
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Lunds universitet
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Karolinska Institutet