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Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS).
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Tajar, Abdelouahid (author)
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Huhtaniemi, Ilpo T (author)
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O'Neill, Terence W (author)
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Finn, Joseph D (author)
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Pye, Stephen R (author)
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Lee, David M (author)
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Bartfai, György (author)
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Boonen, Steven (author)
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Casanueva, Felipe F F (author)
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Forti, Gianni (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Han, Thang S (author)
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Kula, Krzysztof (author)
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Labrie, Fernand (author)
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Lean, Michael E J (author)
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Pendleton, Neil (author)
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Punab, Margus (author)
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Vanderschueren, Dirk (author)
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Wu, Frederick C W (author)
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(creator_code:org_t)
- The Endocrine Society, 2012
- 2012
- English.
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In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 97:5, s. 1508-1516
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Abstract
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- Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries. Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured. Results:Sixty-three men (2.1%) were classified as having LOH: 36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points. Conclusions:LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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Tajar, Abdelouah ...
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Huhtaniemi, Ilpo ...
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O'Neill, Terence ...
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Finn, Joseph D
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Pye, Stephen R
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Lee, David M
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show more...
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Bartfai, György
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Boonen, Steven
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Casanueva, Felip ...
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S
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Kula, Krzysztof
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Labrie, Fernand
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Lean, Michael E ...
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Pendleton, Neil
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Punab, Margus
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Vanderschueren, ...
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Wu, Frederick C ...
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show less...
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- MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
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and Endocrinology an ...
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Lund University