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Polyphenol intake a...
Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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- Zamora-Ros, Raul (author)
- Bellvitge Biomedical Research Institute
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- Cayssials, Valerie (author)
- Bellvitge Biomedical Research Institute
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- Franceschi, Silvia (author)
- CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute
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- Kyrø, Cecilie (author)
- Danish Cancer Society
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization
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- Hennings, Joakim, 1969- (author)
- Umeå universitet,Umeå University,Kirurgi
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- Sandström, Maria (author)
- Umeå universitet,Umeå University,Onkologi
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- Tjønneland, Anne (author)
- Danish Cancer Society
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- Olsen, Anja (author)
- Danish Cancer Society
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- Overvad, Kim (author)
- Aarhus University
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- Boutron-Ruault, Marie Christine (author)
- Institut Gustave Roussy,University of Paris-Saclay
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- Truong, Thérèse (author)
- University of Paris-Saclay
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- Mancini, Francesca Romana (author)
- Institut Gustave Roussy,University of Paris-Saclay
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- Katzke, Verena (author)
- German Cancer Research Centre
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- Kühn, Tilman (author)
- German Cancer Research Centre
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens
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- Karakatsani, Anna (author)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Martimianaki, Georgia (author)
- Hellenic Health Foundation, Athens
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- Palli, Domenico (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Krogh, Vittorio (author)
- Istituto Nazionale dei Tumori
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital
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- Sacerdote, Carlotta (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Lasheras, Cristina (author)
- University of Oviedo
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- Rodríguez-Barranco, Miguel (author)
- University of Granada
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- Amiano, Pilar (author)
- Hospital Universitario Donostia,CIBER Epidemiology and Public Health (CIBERESP)
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- Colorado-Yohar, Sandra M. (author)
- Murcia Regional Health Council,University of Antioquia,CIBER Epidemiology and Public Health (CIBERESP)
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- Ardanaz, Eva (author)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Almquist, Martin (author)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Bueno-de-Mesquita, H. Bas (author)
- National Institute for Public Health and the Environment (RIVM),Imperial College London,University Medical Center Utrecht,University of Malaya
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- Vermeulen, Roel (author)
- University Medical Center Utrecht,Utrecht University
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- Schmidt, Julie A. (author)
- University of Oxford,Bellvitge Biomedical Research Institute
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- Byrnes, Graham (author)
- International Agency for Research on Cancer, World Health Organization
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- Scalbert, Augustin (author)
- International Agency for Research on Cancer, World Health Organization
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- Agudo, Antonio (author)
- Bellvitge Biomedical Research Institute
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- Rinaldi, Sabina (author)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2019-08-07
- 2020
- English 10 s.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 146:7, s. 1841-1850
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Abstract
Subject headings
Close
- Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77–1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80–1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55–2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cohort
- EPIC
- flavonoids
- intake
- polyphenols
- thyroid cancer
- polyphenols
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Zamora-Ros, Raul
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Cayssials, Valer ...
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Franceschi, Silv ...
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Kyrø, Cecilie
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Weiderpass, Elis ...
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Hennings, Joakim ...
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show more...
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Sandström, Maria
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Kim
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Boutron-Ruault, ...
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Truong, Thérèse
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Mancini, Frances ...
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Katzke, Verena
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Kühn, Tilman
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Boeing, Heiner
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Trichopoulou, An ...
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Karakatsani, Ann ...
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Martimianaki, Ge ...
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Palli, Domenico
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Krogh, Vittorio
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Panico, Salvator ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Lasheras, Cristi ...
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Rodríguez-Barran ...
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Amiano, Pilar
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Colorado-Yohar, ...
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Ardanaz, Eva
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Almquist, Martin
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Ericson, Ulrika
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Bueno-de-Mesquit ...
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Vermeulen, Roel
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Schmidt, Julie A ...
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Byrnes, Graham
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Scalbert, August ...
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Agudo, Antonio
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Rinaldi, Sabina
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Lund University
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Umeå University