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May P-glycoprotein ...
May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol
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Serra, Massimo (författare)
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Pasello, Michela (författare)
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Manara, Maria Cristina (författare)
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visa fler...
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Scotlandi, Katia (författare)
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Ferrari, Stefano (författare)
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Bertoni, Franco (författare)
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Mercuri, Mario (författare)
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- Alvegård, Thor (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Picci, Piero (författare)
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Bacc, Gaetano (författare)
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Smeland, Sigbjorn (författare)
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visa färre...
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: International Journal of Oncology. - 1019-6439. ; 29:6, s. 1459-1468
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- The aim was to evaluate the clinical impact of P-glycoprotein in primary non-metastatic high-grade osteosarcoma patients, treated with neoadjuvant chemotherapy protocols. P-glycoprotein was assessed by immunohistochemistry on paraffin-embedded tissue samples collected at time of diagnosis from 94 osteosarcoma patients, treated with the Italian Sarcoma Group/Scandinavian Sarcoma Group 1 (ISG/SSG 1) protocol. P-glycoprotein-positivity at diagnosis was found in 53/94 ISG/SSG 1 cases (56%) and emerged as the single factor significantly associated with an unfavourable outcome from survival and multivariate analyses. A comparative analysis of the subgroup of 94 patients considered for P-glycoprotein evaluation and the whole series of ISG/SSG 1 patients showed that this marker retained its prognostic value also in the latter group. In osteosarcoma patients treated with doxorubicin-based chemotherapy protocols, P-glycoprotein overexpression at diagnosis is an important adverse prognostic factor for outcome. P-glycoprotein evaluation can therefore constitute the basis for stratifying, at diagnosis, osteosarcoma patients for whom alternative treatments may be considered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- prognosis
- chemotherapy
- drug resistance
- osteosarcoma
- P-glycoprotein
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Serra, Massimo
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Pasello, Michela
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Manara, Maria Cr ...
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Scotlandi, Katia
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Ferrari, Stefano
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Bertoni, Franco
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visa fler...
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Mercuri, Mario
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Alvegård, Thor
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Picci, Piero
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Bacc, Gaetano
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Smeland, Sigbjor ...
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visa färre...
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