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The extent of linka...
The extent of linkage disequilibrium in Arabidopsis thaliana
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- Nordborg, M (author)
- University of Southern California, Los Angeles, USA,Salk Institute for Biological Studies, La Jolla, California, USA
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- Borevitz, JO (author)
- Salk Institute for Biological Studies, La Jolla, California, USA
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- Bergelson, J (author)
- University of Chicago, Illinois, USA
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- Berry, CC (author)
- University of California, San Diego, La Jolla, USA
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- Chory, J (author)
- Salk Institute for Biological Studies, La Jolla, California, USA
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- Hagenblad, Jenny (author)
- Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science,Lund University, Sweden
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- Kreitman, M (author)
- University of Chicago, Illinois, USA
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Maloof, JN (author)
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- Noyes, T (author)
- Stanford University School of Medicine, California, USA
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- Oefner, PJ (author)
- Stanford University School of Medicine, California, USA
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- Stahl, EA (author)
- University of Chicago, Illinois, USA
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- Weigel, D (author)
- Salk Institute for Biological Studies, La Jolla, California, USA
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(creator_code:org_t)
- 2002-01-07
- 2002
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 30:2, s. 190-193
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Abstract
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- Linkage disequilibrium (LD), the nonrandom occurrence of alleles in haplotypes, has long been of interest to population geneticists. Recently, the rapidly increasing availability of genomic polymorphism data has fueled interest in LD as a tool for fine-scale mapping, in particular for human disease loci(1). The chromosomal extent of LD is crucial in this context, because it determines how dense a map must be for associations to be detected and, conversely, limits how finely loci may be mapped(2). Arabidopsis thaliana is expected to harbor unusually extensive LD because of its high degree of selfing(3). Several polymorphism studies have found very strong LD within individual loci, but also evidence of some recombination(4-6). Here we investigate the pattern of LD on a genomic scale and show that in global samples, LD decays within approximately 1 cM, or 250 kb. We also show that LD in local populations may be much stronger than that of global populations, presumably as a result of founder events. The combination of a relatively high level of polymorphism and extensive haplotype structure bodes well for developing a genome-wide LD map in A. thaliana.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Nordborg, M
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Borevitz, JO
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Bergelson, J
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Berry, CC
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Chory, J
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Hagenblad, Jenny
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show more...
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Kreitman, M
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Maloof, JN
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Noyes, T
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Oefner, PJ
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Stahl, EA
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Weigel, D
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Lund University
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Linköping University