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The association of ...
The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men
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Tajar, Abdelouahid (author)
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Lee, David M. (author)
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Pye, Stephen R. (author)
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O'Connell, Matthew D. L. (author)
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Ravindrarajah, Rathi (author)
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Gielen, Evelien (author)
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Boonen, Steven (author)
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Vanderschueren, Dirk (author)
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Pendleton, Neil (author)
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Finn, Joseph D. (author)
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Bartfai, Gyoergy (author)
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Casanueva, Felipe F. (author)
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Forti, Gianni (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Han, Thang S. (author)
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Huhtaniemi, Ilpo T. (author)
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Kula, Krzysztof (author)
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Lean, Michael E. J. (author)
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Punab, Margus (author)
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Wu, Frederick C. W. (author)
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O'Neill, Terence W. (author)
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(creator_code:org_t)
- 2012-10-30
- 2013
- English.
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In: Age and Ageing. - : Oxford University Press (OUP). - 1468-2834 .- 0002-0729. ; 42:3, s. 352-359
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Abstract
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- Background: the link between the vitamin D endocrine axis and frailty remains undefined, with few studies examining the joint effect of vitamin D and parathyroid hormone (PTH) levels. Our objective was to determine the association of frailty with serum 25-hydroxyvitamin D (25(OH) D) and PTH. Setting: cross-sectional analysis within the European Male Ageing Study (EMAS). Participants: a total of 1,504 community-dwelling men aged 60-79 years. Methods: frailty was classified using a frailty phenotype (FP) and frailty index (FI). The association of frailty with 25(OH)D and PTH was examined using multinomial logistic regression; individual FP criteria with 25(OH)D and PTH using binary logistic regression. Results were expressed as relative odds ratios (ROR) and 95% confidence intervals (CIs) for multinomial; odds ratios (OR) and 95% CIs for binary models. Results: using the FP, 5.0% of subjects were classified as frail and 36.6% as prefrail. Lower levels of 25(OH)D were associated with being prefrail (per 1 SD decrease: ROR = 1.45; 95% CI: 1.26-1.67) and frail (ROR = 1.89; 95% CI: 1.30-2.76), after adjusting for age, centre and health and lifestyle confounders (robust group = base category). Higher levels of PTH were associated with being frail after adjustment for confounders (per 1 SD increase: ROR = 1.24; 95% CI: 1.01-1.52). Comparable results were found using the FI. Among the five FP criteria only sarcopenia was not associated with 25(OH)D levels, while only weakness was associated with PTH. Conclusion: lower 25(OH)D and higher PTH levels were positively associated with frailty in older men. Prospective data would enable the temporal nature of this relationship to be explored further.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- frailty
- vitamin D
- parathyroid hormone
- population-based
- male health
- ageing
- EMAS
- older people
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tajar, Abdelouah ...
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Lee, David M.
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Pye, Stephen R.
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O'Connell, Matth ...
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Ravindrarajah, R ...
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Gielen, Evelien
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show more...
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Boonen, Steven
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Vanderschueren, ...
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Pendleton, Neil
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Finn, Joseph D.
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Bartfai, Gyoergy
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Casanueva, Felip ...
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S.
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Lean, Michael E. ...
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Punab, Margus
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Wu, Frederick C. ...
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O'Neill, Terence ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Age and Ageing
- By the university
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Lund University