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Dietary Intake and ...
Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children : A Mediation Analysis Using the TEDDY Cohort
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- Aronsson, Carin Andrén (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Tamura, Roy (author)
- University of South Florida
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- Vehik, Kendra (author)
- University of South Florida
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- Uusitalo, Ulla (author)
- University of South Florida
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- Yang, Jimin (author)
- University of South Florida
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- Haller, Michael J. (author)
- University of Florida
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- Toppari, Jorma (author)
- University of Turku,Turku University Hospital
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- McIndoe, Richard A. (author)
- Medical College of Georgia
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- Rewers, Marian J. (author)
- Barbara Davis Center for Childhood Diabetes
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- Ziegler, Anette G. (author)
- Klinikum rechts der Isar
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Krischer, Jeffrey P. (author)
- University of South Florida
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- Norris, Jill M. (author)
- University of Colorado
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- Virtanen, Suvi M. (author)
- Tampere University Hospital,Finnish National Institute for Health and Welfare,University of Tampere
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- Larsson, Helena Elding (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- Hindawi Limited, 2023
- 2023
- English.
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In: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 2023
- Related links:
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Abstract
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- Background/Objective: Growth and obesity have been associated with increased risk of islet autoimmunity (IA) and progression to type 1 diabetes. We aimed to estimate the effect of energy-yielding macronutrient intake on the development of IA through BMI. Research Design and Methods: Genetically at-risk children (n = 5,084) in Finland, Germany, Sweden, and the USA, who were autoantibody negative at 2 years of age, were followed to the age of 8 years, with anthropometric measurements and 3-day food records collected biannually. Of these, 495 (9.7%) children developed IA. Mediation analysis for time-varying covariates (BMI z-score) and exposure (energy intake) was conducted. Cox proportional hazard method was used in sensitivity analysis. Results: We found an indirect effect of total energy intake (estimates: indirect effect 0.13 [0.05, 0.21]) and energy from protein (estimates: indirect effect 0.06 [0.02, 0.11]), fat (estimates: indirect effect 0.03 [0.01, 0.05]), and carbohydrates (estimates: indirect effect 0.02 [0.00, 0.04]) (kcal/day) on the development of IA. A direct effect was found for protein, expressed both as kcal/day (estimates: direct effect 1.09 [0.35, 1.56]) and energy percentage (estimates: direct effect 72.8 [3.0, 98.0]) and the development of GAD autoantibodies (GADA). In the sensitivity analysis, energy from protein (kcal/day) was associated with increased risk for GADA, hazard ratio 1.24 (95% CI: 1.09, 1.53), p = 0.042. Conclusions: This study confirms that higher total energy intake is associated with higher BMI, which leads to higher risk of the development of IA. A diet with larger proportion of energy from protein has a direct effect on the development of GADA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Aronsson, Carin ...
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Tamura, Roy
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Vehik, Kendra
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Uusitalo, Ulla
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Yang, Jimin
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Haller, Michael ...
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show more...
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Toppari, Jorma
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Hagopian, Willia ...
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McIndoe, Richard ...
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Rewers, Marian J ...
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Ziegler, Anette ...
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Akolkar, Beena
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Krischer, Jeffre ...
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Norris, Jill M.
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Virtanen, Suvi M ...
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Larsson, Helena ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Pediatric Diabet ...
- By the university
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Lund University