Sökning: (WFRF:(Madsen Anja Lykke)) >
Protocol for the co...
Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort
-
- Bjørnsbo, Kirsten Schroll (författare)
- Copenhagen University Hospital
-
- Brøns, Charlotte (författare)
- Steno Diabetes Center Copenhagen
-
- Aadahl, Mette (författare)
- Copenhagen University Hospital
-
visa fler...
-
- Kampmann, Freja Bach (författare)
- Copenhagen University Hospital
-
- Nielsen, Camilla Friis Bryde (författare)
- Copenhagen University Hospital
-
- Lundbergh, Bjørn (författare)
- Copenhagen University Hospital
-
- Christensen, Rasmus Wibaek (författare)
- Steno Diabetes Center Copenhagen
-
- Kårhus, Line Lund (författare)
- Copenhagen University Hospital
-
- Madsen, Anja Lykke (författare)
- Copenhagen University Hospital
-
- Hansen, Christian Stevns (författare)
- Steno Diabetes Center Copenhagen
-
- Nørgaard, Kirsten (författare)
- Steno Diabetes Center Copenhagen,Copenhagen University Hospital
-
- Jørgensen, Niklas Rye (författare)
- Copenhagen University Hospital
-
- Suetta, Charlotte (författare)
- Bispebjerg Hospital
-
- Kjaer, Michael (författare)
- Bispebjerg Hospital
-
- Grarup, Niels (författare)
- Novo Nordisk Foundation Centre for Basic Metabolic Research
-
- Kanters, Jørgen (författare)
- Novo Nordisk Foundation Centre for Basic Metabolic Research,University of California, San Francisco
-
- Larsen, Michael (författare)
- Copenhagen University Hospital
-
- Køber, Lars (författare)
- Copenhagen University Hospital
-
- Kofoed, Klaus Fuglsang (författare)
- Copenhagen University Hospital
-
- Loos, Ruth (författare)
- Novo Nordisk Foundation Centre for Basic Metabolic Research
-
- Hansen, Torben (författare)
- Novo Nordisk Foundation Centre for Basic Metabolic Research
-
- Linneberg, Allan (författare)
- Copenhagen University Hospital
-
- Vaag, Allan (författare)
- Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Skåne University Hospital,Steno Diabetes Center Copenhagen
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: BMJ Open. - 2044-6055. ; 14:1
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction The population-based Inter99 cohort has contributed extensively to our understanding of effects of a systematic screening and lifestyle intervention, as well as the multifactorial aetiology of type 2 diabetes (T2D) and cardiovascular disease. To understand causes, trajectories and patterns of early and overt cardiometabolic disease manifestations, we will perform a combined clinical deep phenotyping and registry follow-up study of the now 50–80 years old Inter99 participants. Methods and analysis The Inter99 cohort comprises individuals aged 30–60 years, who lived in a representative geographical area of greater Copenhagen, Denmark, in 1999. Age-stratified and sex-stratified random subgroups were invited to participate in either a lifestyle intervention (N=13 016) or questionnaires (N=5264), while the rest served as a reference population (N=43 021). Of the 13 016 individuals assigned to the lifestyle intervention group, 6784 (52%) accepted participation in a baseline health examination in 1999, including screening for cardiovascular risk factors and prediabetic conditions. In total, 6004 eligible participants, who participated in the baseline examination, will be invited to participate in the deep phenotyping 20-year follow-up clinical examination including measurements of anthropometry, blood pressure, arterial stiffness, cardiometabolic biomarkers, coronary artery calcification, heart rate variability, heart rhythm, liver stiffness, fundus characteristics, muscle strength and mass, as well as health and lifestyle questionnaires. In a subsample, 10-day monitoring of diet, physical activity and continuous glucose measurements will be performed. Fasting blood, urine and faecal samples to be stored in a biobank. The established database will form the basis of multiple analyses. A main purpose is to investigate whether low birth weight independent of genetics, lifestyle and glucose tolerance predicts later common T2D cardiometabolic comorbidities. Ethics and dissemination The study was approved by the Medical Ethics Committee, Capital Region, Denmark (H-20076231) and by the Danish Data Protection Agency through the Capital Region of Denmark’s registration system (P-2020-1074). Informed consent will be obtained before examinations. Findings will be disseminated in peer-reviewed journals, at conferences and via presentations to stakeholders, including patients and public health policymakers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
-
BMJ Open
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Bjørnsbo, Kirste ...
-
Brøns, Charlotte
-
Aadahl, Mette
-
Kampmann, Freja ...
-
Nielsen, Camilla ...
-
Lundbergh, Bjørn
-
visa fler...
-
Christensen, Ras ...
-
Kårhus, Line Lun ...
-
Madsen, Anja Lyk ...
-
Hansen, Christia ...
-
Nørgaard, Kirste ...
-
Jørgensen, Nikla ...
-
Suetta, Charlott ...
-
Kjaer, Michael
-
Grarup, Niels
-
Kanters, Jørgen
-
Larsen, Michael
-
Køber, Lars
-
Kofoed, Klaus Fu ...
-
Loos, Ruth
-
Hansen, Torben
-
Linneberg, Allan
-
Vaag, Allan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
BMJ Open
- Av lärosätet
-
Lunds universitet