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1.	Kim, Min, et al. (author) Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort 2019 In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 15:6, s. 817-827 Journal article (peer-reviewed)abstract INTRODUCTION: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.METHODS: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.RESULTS: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.DISCUSSION: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.
2.	Waluk, Dominik P., et al. (author) Mammalian Fatty Acid Amides of the Brain and CNS 2014 In: Omega-3 Fatty Acids in Brain and Neurological Health. - London : Academic Press Ltd-Elsevier Science Ltd. - 9780124105478 - 9780124105270 ; , s. 87-107 Book chapter (peer-reviewed)

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Type of publication: journal article (1); book chapter (1)

Type of content: peer-reviewed (2)

Author/Editor: Merkler, David J (2); Blennow, Kaj, 1958 (1); Zetterberg, Henrik, ... (1); Tsolaki, Magda (1); Wallin, Anders, 1950 (1); Kettunen, Petronella (1); show more...; Vandenberghe, Rik (1); Scheltens, Philip (1); Ali, Ashfaq (1); Barkhof, Frederik (1); Suvitaival, Tommi (1); Ashton, Nicholas J. (1); Martínez-Lage, Pablo (1); Lleó, Alberto (1); Rami, Lorena (1); Frisoni, Giovanni B. (1); Engelborghs, Sebasti ... (1); Molinuevo, José L (1); Hye, Abdul (1); Lovestone, Simon (1); Snowden, Stuart (1); Teunissen, Charlotte (1); Freund-Levi, Yvonne, ... (1); Bertram, Lars (1); Sleegers, Kristel (1); Frölich, Lutz (1); Bos, Isabelle (1); Johannsen, Peter (1); Verhey, Frans (1); Hunt, Mary C (1); Popp, Julius (1); Dobricic, Valerija (1); Tainta, Mikel (1); Peyratout, Gwendolin ... (1); Streffer, Johannes (1); Bordet, Régis (1); Visser, Pieter J (1); Kim, Min (1); Legido-Quigley, Cris ... (1); Proitsi, Petroula (1); Gabel, Silvy (1); Blin, Olivier (1); Ten Kate, Mara (1); Sala, Isabel (1); Ahmad, Tahmina (1); Westwood, Sarah (1); Baird, Alison (1); Nevado-Holgado, Alej ... (1); Vos, Stephanie (1); Meersmans, Karen (1); show less...

University: University of Gothenburg (1); Stockholm University (1); Örebro University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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