| 1. |
- Glasbey, JC, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Davies, Stuart J., et al.
(författare)
-
ForestGEO: Understanding forest diversity and dynamics through a global observatory network
- 2021
-
Ingår i: Biological Conservation. - : Elsevier BV. - 0006-3207. ; 253
-
Tidskriftsartikel (refereegranskat)abstract
- ForestGEO is a network of scientists and long-term forest dynamics plots (FDPs) spanning the Earth's major forest types. ForestGEO's mission is to advance understanding of the diversity and dynamics of forests and to strengthen global capacity for forest science research. ForestGEO is unique among forest plot networks in its large-scale plot dimensions, censusing of all stems ≥1 cm in diameter, inclusion of tropical, temperate and boreal forests, and investigation of additional biotic (e.g., arthropods) and abiotic (e.g., soils) drivers, which together provide a holistic view of forest functioning. The 71 FDPs in 27 countries include approximately 7.33 million living trees and about 12,000 species, representing 20% of the world's known tree diversity. With >1300 published papers, ForestGEO researchers have made significant contributions in two fundamental areas: species coexistence and diversity, and ecosystem functioning. Specifically, defining the major biotic and abiotic controls on the distribution and coexistence of species and functional types and on variation in species' demography has led to improved understanding of how the multiple dimensions of forest diversity are structured across space and time and how this diversity relates to the processes controlling the role of forests in the Earth system. Nevertheless, knowledge gaps remain that impede our ability to predict how forest diversity and function will respond to climate change and other stressors. Meeting these global research challenges requires major advances in standardizing taxonomy of tropical species, resolving the main drivers of forest dynamics, and integrating plot-based ground and remote sensing observations to scale up estimates of forest diversity and function, coupled with improved predictive models. However, they cannot be met without greater financial commitment to sustain the long-term research of ForestGEO and other forest plot networks, greatly expanded scientific capacity across the world's forested nations, and increased collaboration and integration among research networks and disciplines addressing forest science.
|
|
| 5. |
- Dhamal, Swapnil Vilas, 1988, et al.
(författare)
-
A Multi-phase Approach for Improving Information Diffusion in Social Networks
- 2015
-
Ingår i: AAMAS 2015 - Proceedings of the 14th International Conference on Autonomous Agents and MultiAgent Systems. - 9781450334136 ; , s. 1787-1788
-
Konferensbidrag (refereegranskat)abstract
- For maximizing influence spread in a social network, given a certain budget on the number of seed nodes, we investigate the effects of selecting and activating the seed nodes in multiple phases. In particular, we formulate an appropriate objective function for two-phase influence maximization under the independent cascade model, investigate its properties, and propose algorithms for determining the seed nodes in the two phases. We also study the problem of determining an optimal budget-split and delay between the two phases.
|
|
| 6. |
- Dhamal, Swapnil Vilas, 1988, et al.
(författare)
-
Information Diffusion in Social Networks in Two Phases
- 2016
-
Ingår i: IEEE Transactions on Network Science and Engineering. - 2327-4697. ; 3:4, s. 197-210
-
Tidskriftsartikel (refereegranskat)abstract
- The problem of maximizing information diffusion, given a certain budget expressed in terms of the number of seed nodes, is an important topic in social networks research. Existing literature focuses on single phase diffusion where all seed nodes are selected at the beginning of diffusion and all the selected nodes are activated simultaneously. This paper undertakes a detailed investigation of the effect of selecting and activating seed nodes in multiple phases. Specifically, we study diffusion in two phases assuming the well-studied independent cascade model. First, we formulate an objective function for two-phase diffusion, investigate its properties, and propose efficient algorithms for finding seed nodes in the two phases. Next, we study two associated problems: (1) budget splitting which seeks to optimally split the total budget between the two phases and (2) scheduling which seeks to determine an optimal delay after which to commence the second phase. Our main conclusions include: (a) under strict temporal constraints, use single phase diffusion, (b) under moderate temporal constraints, use two-phase diffusion with a short delay while allocating most of the budget to the first phase, and (c) when there are no temporal constraints, use two-phase diffusion with a long delay while allocating roughly one-third of the budget to the first phase.
|
|
| 7. |
- Jamir, Esther, et al.
(författare)
-
Applying polypharmacology approach for drug repurposing for SARS-CoV2
- 2022
-
Ingår i: Journal of Chemical Sciences. - : Springer Nature. - 0974-3626 .- 0973-7103. ; 134:2
-
Tidskriftsartikel (refereegranskat)abstract
- Exploring the new therapeutic indications of known drugs for treating COVID-19, popularly known as drug repurposing, is emerging as a pragmatic approach especially owing to the mounting pressure to control the pandemic. Targeting multiple targets with a single drug by employing drug repurposing known as the polypharmacology approach may be an optimised strategy for the development of effective therapeutics. In this study, virtual screening has been carried out on seven popular SARS-CoV-2 targets (3CL(pro), PLpro, RdRp (NSP12), NSP13, NSP14, NSP15, and NSP16). A total of 4015 approved drugs were screened against these targets. Four drugs namely venetoclax, tirilazad, acetyldigitoxin, and ledipasvir have been selected based on the docking score, ability to interact with four or more targets and having a reasonably good number of interactions with key residues in the targets. The MD simulations and MM-PBSA studies showed reasonable stability of protein-drug complexes and sustainability of key interactions between the drugs with their respective targets throughout the course of MD simulations. The identified four drug molecules were also compared with the known drugs namely elbasvir and nafamostat. While the study has provided a detailed account of the chosen protein-drug complexes, it has explored the nature of seven important targets of SARS-CoV-2 by evaluating the protein-drug complexation process in great detail.
|
|
| 8. |
- Piponiot, Camille, et al.
(författare)
-
Distribution of biomass dynamics in relation to tree size in forests across the world
- 2022
-
Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 234, s. 1664-1677
-
Tidskriftsartikel (refereegranskat)abstract
- Tree size shapes forest carbon dynamics and determines how trees interact with their environment, including a changing climate. Here, we conduct the first global analysis of among-site differences in how aboveground biomass stocks and fluxes are distributed with tree size. We analyzed repeat tree censuses from 25 large-scale (4–52 ha) forest plots spanning a broad climatic range over five continents to characterize how aboveground biomass, woody productivity, and woody mortality vary with tree diameter. We examined how the median, dispersion, and skewness of these size-related distributions vary with mean annual temperature and precipitation. In warmer forests, aboveground biomass, woody productivity, and woody mortality were more broadly distributed with respect to tree size. In warmer and wetter forests, aboveground biomass and woody productivity were more right skewed, with a long tail towards large trees. Small trees (1–10 cm diameter) contributed more to productivity and mortality than to biomass, highlighting the importance of including these trees in analyses of forest dynamics. Our findings provide an improved characterization of climate-driven forest differences in the size structure of aboveground biomass and dynamics of that biomass, as well as refined benchmarks for capturing climate influences in vegetation demographic models.
|
|
