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- Bergqvist, Lennart, et al.
(författare)
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Particle sizing and biokinetics of interstitiallymphoscintigraphic agents
- 1983
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Ingår i: Seminars in Nuclear Medicine. - 0001-2998. ; 13:1, s. 9-19
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Tidskriftsartikel (refereegranskat)abstract
- The biokinetics of inert lymphoscintigraphic agentsstrongly depends on their particle size. Different techniques for characterization of colloids are discussed. Experiments have been performed on eight different colloids. The particle size has been investigated with scanning electron microscopy. Activity distributions have been obtained with ultrafiltration and gel-column scanning technique. The colloids suggested for lymphoscintigraphy were found to have a median size of about 40-50 nm except one minimicro-aggregated human serum albumin colloid which has a median particle size around 10 nm. The biokinetics were studied with a scintillation camera in rabbits after a subcutaneous injection. Timeactivity curves were generated. After 5 hr the rabbits were dissected and the activity content in different tissues measured. A compartment model for the biokinetics was designed and rate constants evaluated. The total and specific activity uptake in parasternal lymph nodes was highest for the small-particle colloids. The compartment model showed a good fitting to the experimental data.
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| 2. |
- Darte, Lennart, et al.
(författare)
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Quality control of 99mTc-radiopharmaceuticals - Evaluation of GCS minicolumns in routine clinical work with scintillation cameras
- 1980
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Ingår i: European Journal Of Nuclear Medicine. - 0340-6997. ; 5:6, s. 521-527
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Tidskriftsartikel (refereegranskat)abstract
- Gel chromatography column scanning (GCS) is a rapid and reliable method for the quality control of 99mTc-radiopharmaceuticals. With this method the labelled compound and various impurities such as free pertechnetate, hydrolyzed reduced technetium or other 99mTc-complexes are obtained in one testing procedure. Using minicolumns results can be obtained with a simple testing procedure within a few minutes after the sample is taken; this is significant in routine radiopharmaceutical work. The resolution of the recording system is important, so as to be able to utilize fully the good separation ability of the minicolumn. Minicolumns were studied with some commonly used radiopharmaceuticals. A scintillation camera was used to record minicolumn data under various conditions and the results were compared to those obtained using a scanner to reveal optimal recording conditions for the scintillation camera.
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